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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Cardiovascular Medicine
  • Cardiovascular Medicine Department
  • Endomyocardial Biopsy
  • Heart Failure Section
  • Right Heart Catheterization
View all 5 Treatment & Services +

Specialty in Diseases & Conditions

  • Cardiomyopathy
  • Heart Failure
View all 2 Specialties +


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About Karlee Hoffman, DO

Karlee Hoffman, DO, is a heart failure specialist in the Heart Failure & Cardiac Transplantation Section of the Tomsich Family Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute. She sees patients at main campus.

Specialty Interests: Advanced heart failure, transplant, left ventricular assist devices (LVADs), cardiogenic shock, high risk cardiac disease in pregnancy

Experience: The Heart Failure & Cardiac Transplantation Section is part of Cleveland Clinic’s George M. and Linda H. Kaufman Center for Heart Failure Treatment and Recovery, one of the premier facilities in the United States for the care of people with heart failure. Center physicians aggressively pursue non-transplant options to benefit these patients and also continue to investigate and improve surgical treatments, such as LVADs, left ventricular reconstruction surgery and heart transplant. Cleveland Clinic's cardiac transplant program is one of the largest in the United States.

During her year as a Cleveland Clinic fellow in advanced heart failure, Dr. Hoffman performed more than 100 endomyocardial biopsies and more than 250 right heart catheterizations. 
Education: Dr. Hoffman earned a Doctorate of Osteopathic Medicine from Philadelphia College of Osteopathic Medicine in Philadelphia. She served her internal medicine residency followed by a cardiology fellowship with Allegheny Health Network, Pittsburgh, Pa. Dr. Hoffman completed her subspecialty training as a fellow in Advanced Heart Failure and Transplantation at Cleveland Clinic.

She was named to the Cleveland Clinic medical staff in 2020 on completion of her fellowship. She is board certified in Internal Medicine, Cardiovascular Disease, and Advanced Heart Failure and Transplant Cardiology.

Research, Publications and Speaking: As a cardiology fellow at Allegheny Health Network, Dr. Hoffman was an investigator on research studies on preeclampsia and the long-term risk of the development of cardiovascular risk factors and cardiovascular disease and a collaborative LVAD recovery study with The University of Utah using RNA tissue analysis to predict response to LVAD. She also was the lead fellow in development of a pilot program to provide heart-healthy diets for patients diagnosed with heart failure who met food insecurity criteria. She presented findings from these studies at regional and national medical meetings, including the American College of Physicians, American College of Cardiology, and American Heart Association.

About Dr. Hoffman  "I enjoy caring for advanced heart failure and transplant patients because I have the opportunity to build longstanding relationships with my patients and take care of them when they are at their most vulnerable state, with no other treatment options. This field is extremely high-risk, high-reward, and I would not want it any other way. Every time I am involved with a new heart transplant, I get excited because it is truly a miracle and such a wonderful gift of life. It is a privilege to take care of these patients, and I do not take this responsibility for granted.”

Leisure Activities: Dr. Hoffman enjoys being outdoors and spending time with her husband, young children, and the family dog. She and her husband also enjoy watching and caring for the family’s Standardbred racehorses.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Advanced Heart Failure and Transplant Cardiology
Cleveland, OH USA

Fellowship - Allegheny HealthNetwork Medical Education Consortium
Pittsburgh, PA USA

Residency - Allegheny HealthNetwork Medical Education Consortium
Internal Medicine
Pittsburgh, PA USA

Medical Education - Philadelphia College of Osteopathic Medicine
Philadelphia, PA USA

Undergraduate - Washington and Jefferson College
Cellular and Molecular Biology
Washington, PA USA


  • Internal Medicine - Advanced Heart Failure and Transplant Cardiology
  • Internal Medicine
  • Internal Medicine - Cardiovascular Disease

Specialty Interests

Advanced heart failure, transplant, left ventricular assist devices (LVADs), cardiogenic shock

Research & Publications

Research & Publications

See publications for Karlee Hoffman, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/6/2023, Dr. Hoffman has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

220 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.7
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

41 Patient Comments

Reviewed on Mar 26, 2024

Dr. Hoffman is kind and attentive I am sure she is very busy but takes the time to respond to my concerns and question.

Reviewed on Feb 20, 2024

Dr. Hoffman and staff been outstanding. I appreciate the service.

Reviewed on Jan 25, 2024

Dr Hoffman and the LVAD team are ROCKSTARS

Reviewed on Jan 10, 2024

Dr Hoffman is very sincere and thoughtful. Her communication is excellent and insights are very helpful

Reviewed on Jan 8, 2024

I had a very good experience in my dealings withDr. Kofffman .

Reviewed on Dec 20, 2023

I am so pleased to have Dr. Hoffman. She listens!!

Reviewed on Dec 19, 2023

DR was by far the best I've ever met. The time she took to review my chart, to discuss the issues and her recommendations were spot on.

Reviewed on Dec 8, 2023

Dr Hoffman was outstanding in every way

Reviewed on Dec 6, 2023

Dr Hoffman was tremendous, I couldn't have a better Doctor

Reviewed on Nov 14, 2023

All of them in this appointment were just wonderful, kind and helpful and very encouraging a Dr. Hoffman was very sweet and gave a very good explanation simple enough for even me to understand and get the true feeling of what is wrong with my heart. I was very impressed with all of them the way they handled me and the test. It was painful, but they were so kind and understanding and encouraged me to do my best to get the best reading. I cannot say how much I am so thankful for all of them for being so good to me and helping me.

Reviewed on Nov 14, 2023

The care there was outstanding like I said, the only thing I did not feel good about was the cardiologist doctor, Irwin or Everin, or something like that , he needs a check on his bedside manner. He did not listen. He kept cutting me off, and he poo, poo anything I said about me, knowing how my body feels, and that something was very wrong. He had very strong opinions and I didn't feel they came across with kindness and care, but that did not deter me from saying I had good treatment there, Dr. Vargo was absolutely wonderful and his office was outstanding and taking care of me KATYA, his administrative assistant and his nurse were just wonderful kind patient and truly I so wish they could have surgically fix this and I'd go home with better health but what is wrong they cannot fix, but I went home with calmness and peace in my heart. At least I know what it is and how to live with it and how to face it

Reviewed on Nov 11, 2023

Dr. Karlee Hoffman is an amazing Doctor & human being! I would recommend her to everyone!

Reviewed on Nov 8, 2023

I brag on her all the time. I definitely recommend a lot. I am so thankful for her!

Reviewed on Oct 18, 2023

Dr. Karlee Hoffman has really helped me with my Heart Problems and feeling so much better with living and with her knowledge on everything and getting me on the correct Medications and all . She's the best Cardiologist.

Reviewed on Oct 13, 2023

Dr. Hoffman is the best doctor I've ever had. She is a problem solver and keeps going until there is a solution. I feel so fortunate I was assigned to her care in 2020. She is amazing!

Reviewed on Sep 19, 2023

Usually difficult to arrange visits as I have two doctors I like to see while there. They made this seamless and I really appreciate it.

Reviewed on Aug 23, 2023

Dr. Hoffman is excellent.

Reviewed on Aug 7, 2023

She was so helpful in explaining everything.

Reviewed on Jun 27, 2023

Dr.Hoffmann is awesome to deal with went out of her way to help with advice on much needed exercise.

Reviewed on Jun 27, 2023

The staff from Parking Garage to Dr.Hoffmsnn were pleasant, courteous and professional!

Reviewed on Jun 16, 2023

I like Dr Hoffman very much. She's very informative, and easy to speak with.

Reviewed on Jun 12, 2023

Love the respect I received by Dr K Hoffman. She is fantastic!

Reviewed on Jun 12, 2023

Great doctors

Reviewed on Jun 12, 2023

Dr. Hoffman is both human and professional. She is great at taking a complex subject and explaining it simply. She is both clear in her preferred direction of treatment, while at the same time being sensitive to my knowledge of my body. This is a rare and valuable skill in a physician.

Reviewed on Jun 8, 2023

Dr Hoffman and the entire LVAD team are amazing!

Reviewed on Jun 7, 2023

Dr Hoffman has seen me for two years now and improved my health from heart failure to nearly normal. I travel from Arkansas for her care, she has be absolutely wonderful!

Reviewed on Jun 5, 2023

Great Dr. Compassionate loving caring and most helpful

Reviewed on May 24, 2023

Dr. Hoffman is the best. Not rushed Spent quality time with me and answered all of my questions

Reviewed on May 24, 2023

Dr.Hoffman was very interested in my health.

Reviewed on May 23, 2023

Dr. Hoffman and staff far exceeded my expectations. Dr. Hoffman was thorough, courteous, considerate, and very knowledgeable of heart failure and meds, and treatments to intervene. My confidence was reinforced, and I left the visit motivated to do all I could to follow Dr.'s orders, and to improve my heart function.

Reviewed on May 22, 2023

Dr Hoffman is wonderful. She always is very concerned about my health

Reviewed on May 22, 2023

I am switching my heart health care from University of Michigan to Cleveland Clinic due to Dr. Hoffman.

Reviewed on May 16, 2023

Loved her bedside manner! Friendly, sweet, kind, knowledgeable

Reviewed on May 15, 2023

Dr. Hoffman is an amazing Doctor who really cares about her patients. She has changed my life.

Reviewed on May 10, 2023

My provider is excellent she is very busy.

Reviewed on May 8, 2023

Everything with my appointment with Dr. Hoffman was excellent.

Reviewed on May 8, 2023

Dr Hoffman was very kind, compassionate and assured me that she was going to take care of me. She provided a plan and gave me excellent care.

Reviewed on May 8, 2023

I had the best doctors in the world taking care of me while I was in the hospital. I left Cleveland with a new outlook on life and with hope that I will live many more years with my transplanted heart. Thank you for the excellent care I received.

Reviewed on Apr 14, 2023

Dr Hoffman addressed all of our questions, provided an expert assessment, and conveyed her findings to my local cardiologist. Despite a long day on a Friday afternoon, she was personally present, attentive, and responsive to our questions and concerns.

Reviewed on Apr 10, 2023

Superb doctor! Skilled and compassionate!!

Reviewed on Apr 7, 2023

Very impressed with doctor. She was very friendly and listened to our concerns. Offered suggestions for future testing and possible ways to improve my health problems.

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