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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Cardiovascular Medicine
  • Cardiovascular Medicine Department
  • Endomyocardial Biopsy
  • Heart Failure Section
  • Right Heart Catheterization
View all 5 Treatment & Services +

Specialty in Diseases & Conditions

  • Cardiomyopathy
  • Heart Failure
View all 2 Specialties +


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About Karlee Hoffman, DO

Karlee Hoffman, DO, is a heart failure specialist in the Heart Failure & Cardiac Transplantation Section of the Tomsich Family Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute. She sees patients at main campus.

Specialty Interests: Advanced heart failure, transplant, left ventricular assist devices (LVADs), cardiogenic shock, high risk cardiac disease in pregnancy

Experience: Cleveland Clinic's Department of Vascular Surgery performs more than 5,000 procedures annually for patients with a broad spectrum of vascular diseases at three inpatient, seven outpatient and four ambulatory surgery facilities. Our experts are national and international leaders in treating aneurismal disease of the thoracic and abdominal aorta, occlusive disease in the cerebrovascular circulation via both open and endovascular methods and the provision of dialysis access and minimally invasive treatments for venous disease. The Heart Failure & Cardiac Transplantation Section is part of Cleveland Clinic’s George M. and Linda H. Kaufman Center for Heart Failure Treatment and Recovery, one of the premier facilities in the United States for the care of people with heart failure. Center physicians aggressively pursue non-transplant options to benefit these patients and also continue to investigate and improve surgical treatments, such as LVADs, left ventricular reconstruction surgery and heart transplant. Cleveland Clinic's cardiac transplant program is one of the largest in the United States.

During her year as a Cleveland Clinic fellow in advanced heart failure, Dr. Hoffman performed more than 100 endomyocardial biopsies and more than 250 right heart catheterizations. 
Success Rates: nearly one-third of our services are currently performed to treat those with atherosclerosis, we also provide a significant number of patients with care for aneurysms of the abdominal and thoracic aortas, and in increasing numbers, for those with venous disease.Success rates for specific procedures at Cleveland Clinic are available at

Education: Dr. Hoffman earned a Doctorate of Osteopathic Medicine from Philadelphia College of Osteopathic Medicine in Philadelphia. She served her internal medicine residency followed by a cardiology fellowship with Allegheny Health Network, Pittsburgh, Pa. Dr. Hoffman completed her subspecialty training as a fellow in Advanced Heart Failure and Transplantation at Cleveland Clinic.

She was named to the Cleveland Clinic medical staff in 2020 on completion of her fellowship. She is board certified in Internal Medicine, Cardiovascular Disease, and Advanced Heart Failure and Transplant Cardiology.

Research, Publications and Speaking: As a cardiology fellow at Allegheny Health Network, Dr. Hoffman was an investigator on research studies on preeclampsia and the long-term risk of the development of cardiovascular risk factors and cardiovascular disease and a collaborative LVAD recovery study with The University of Utah using RNA tissue analysis to predict response to LVAD. She also was the lead fellow in development of a pilot program to provide heart-healthy diets for patients diagnosed with heart failure who met food insecurity criteria. She presented findings from these studies at regional and national medical meetings, including the American College of Physicians, American College of Cardiology, and American Heart Association.

About Dr. Hoffman  "I enjoy caring for advanced heart failure and transplant patients because I have the opportunity to build longstanding relationships with my patients and take care of them when they are at their most vulnerable state, with no other treatment options. This field is extremely high-risk, high-reward, and I would not want it any other way. Every time I am involved with a new heart transplant, I get excited because it is truly a miracle and such a wonderful gift of life. It is a privilege to take care of these patients, and I do not take this responsibility for granted.”

Leisure Activities: Dr. Hoffman enjoys traveling, hiking and being outdoors with her husband, young daughter and the family dog. She and her husband also spend a lot of time caring for and training the family’s Standardbred racehorses and watching their races.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Advanced Heart Failure and Transplant Cardiology
Cleveland, OH USA

Fellowship - Allegheny HealthNetwork Medical Education Consortium
Pittsburgh, PA USA

Residency - Allegheny HealthNetwork Medical Education Consortium
Internal Medicine
Pittsburgh, PA USA

Medical Education - Philadelphia College of Osteopathic Medicine
Philadelphia, PA USA

Undergraduate - Washington and Jefferson College
Cellular and Molecular Biology
Washington, PA USA


  • Internal Medicine - Cardiovascular Disease
  • Internal Medicine
  • Internal Medicine - Advanced Heart Failure and Transplant Cardiology

Specialty Interests

Advanced heart failure, transplant, left ventricular assist devices (LVADs), cardiogenic shock

Research & Publications

Research & Publications

See publications for Karlee Hoffman, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 3/31/2022, Dr. Hoffman has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

35 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.7
Listens 4.9
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.7

20 Patient Comments

Reviewed on Feb 24, 2023

Dr. Hoffman is the easiest and most approachable Dr. I have ever had. I am lucky to have her as my caregiver.

Reviewed on Jan 4, 2023

Dr. Hoffman is the best doctor I have ever had. She listens so well and always works to find solutions. She Is extremely responsive if I have a question between appointments when I contact her via MyChart. I was fortunate to have beenI assigned to her care when I was hospitalized two years ago and I have been her patient ever since.

Reviewed on Jan 4, 2023

The doctors are very good

Reviewed on Nov 16, 2022

Execellent doctor personal skills

Reviewed on Nov 16, 2022

I am very happy that I was assigned to Dr. Hoffman

Reviewed on Sep 19, 2022

Doctor is terrific!!!

Reviewed on Sep 19, 2022

Always a pleasant visit with Dr. Hoffman.

Reviewed on Jul 26, 2022

Both Jack and I were very pleased with Dr Hoffman. She went into great detail regarding the amyloidosis. The weight/muscle loss, the liver failure is an indication of "end stage heart failure" which took us off guard. She also mentioned adding protein to his diet.

Reviewed on Jul 26, 2022

Very pleased with the care received. Just overwhelmed by the size of the facility. We just weren't prepared for Jack to be admitted as suggested by Dr Hoffman

Reviewed on Jul 25, 2022

The particular problem is not with this provider but other providers at CC

Reviewed on Jul 21, 2022

She projects a very technically competent engagement and human concern

Reviewed on Jul 16, 2022

(EXCELLENT Doctors.)

Reviewed on Jun 21, 2022

Dr. Hoffman answered all of our questions and put me at ease! She was excellent.

Reviewed on Jun 8, 2022

I appreciate Dr. Hoffman so much! I feel heard and cared about, and I love that we come up with plans so I know what to expect in the future for my condition.

Reviewed on May 26, 2022

Dr. Hoffman was Stellar.

Reviewed on May 25, 2022

During the 20 days I spent in the heart center, I had excellent care by the doctors and their assistants.

Reviewed on May 11, 2022

Dr Hoffman is tremendous is very caring and up front with my care and plan moving forward

Reviewed on Apr 21, 2022

I absolutely love dr Hoffman. She is my favorite dr that I've ever had.

Reviewed on Apr 21, 2022

I'm so glad that I found Dr. Hoffman. After months of not knowing anything about what was going on with me, and feeling like I was left to fend for myself with another hospital she jumped right into trying to figure it out and explained everything thoroughly. I feel like I'm being taken care of properly.

Reviewed on Apr 1, 2022

Dr Hoffman was amazing; she called us directly when portal failed. We can't say enough good things about her!

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