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Department Cardiovascular Medicine
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus

Specialties & Treatments

Treatment & Services

  • Cardiovascular Medicine
  • Cardiovascular Medicine Department
  • Endomyocardial Biopsy
  • Heart Failure Section
  • Right Heart Catheterization
View all 5 Treatment & Services +

Specialty in Diseases & Conditions

  • Cardiomyopathy
  • Heart Failure
View all 2 Specialties +


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About Karlee Hoffman, DO

Karlee Hoffman, DO, is a heart failure specialist in the Heart Failure & Cardiac Transplantation Section of the Tomsich Family Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute. She sees patients at Main Campus.

Specialty Interests: Advanced heart failure, transplant, left ventricular assist devices (LVADs), cardiogenic shock, high risk cardiac disease in pregnancy

Experience: The Heart Failure & Cardiac Transplantation Section is part of Cleveland Clinic’s George M. and Linda H. Kaufman Center for Heart Failure Treatment and Recovery, one of the premier facilities in the United States for the care of people with heart failure. Center physicians aggressively pursue non-transplant options to benefit these patients and also continue to investigate and improve surgical treatments, such as LVADs, left ventricular reconstruction surgery and heart transplant. Cleveland Clinic's cardiac transplant program is one of the largest in the United States.

Education: Dr. Hoffman earned a Doctorate of Osteopathic Medicine from Philadelphia College of Osteopathic Medicine in Philadelphia. She served her internal medicine residency followed by a cardiology fellowship with Allegheny Health Network, Pittsburgh, Pa. Dr. Hoffman completed her subspecialty training as a fellow in Advanced Heart Failure and Transplantation at Cleveland Clinic.

She was named to the Cleveland Clinic medical staff in 2020 on completion of her fellowship. She is board certified in Internal Medicine, Cardiovascular Disease, and Advanced Heart Failure and Transplant Cardiology.

Dr. Hoffman is also a board certified coach and provides professional coaching to her Cleveland Clinic colleagues to help build resilience, retention, and fulfillment within the Cleveland Clinic.

Research, Publications and Speaking: Dr. Hoffman is the co-director of the Cardio-Obstetric multidisciplinary clinic at Main Campus that takes care of high risk cardiac patients with heart failure. She has been invited as a national speaker and has published in high impact journals on her expertise within this field. She is the co-principal investigator for REBIRTH which is a clinical trial investigating the use of bromocriptine in the postpartum cardiomyopathy population. She also is involved in the national patient engagement committee to provide education and engagement for this study surrounding postpartum cardiomyopathy.

About Dr. Hoffman "I enjoy caring for advanced heart failure and transplant patients because I have the opportunity to build longstanding relationships with my patients and take care of them when they are at their most vulnerable state. It is a honor and privilege to take care of these patients, and I do not take this responsibility for granted.”

Leisure Activities: Outside of work, Dr. Hoffman enjoys spending quality time with her family. They love traveling and spending time outdoors with their family dog and horses.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Advanced Heart Failure and Transplant Cardiology
Cleveland, OH

Fellowship - Allegheny Health Network Medical Education Consortium
Pittsburgh, PA

Residency - Allegheny Health Network Medical Education Consortium
Internal Medicine
Pittsburgh, PA

Medical Education - Philadelphia College of Osteopathic Medicine
Philadelphia, PA

Undergraduate - Washington and Jefferson College
Cellular and Molecular Biology
Washington, PA


  • Internal Medicine - Advanced Heart Failure and Transplant Cardiology
  • Internal Medicine
  • Internal Medicine - Cardiovascular Disease

Specialty Interests

Advanced heart failure, transplant, left ventricular assist devices (LVADs), cardiogenic shock

Research & Publications

Research & Publications

See publications for Karlee Hoffman, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/8/2024, Dr. Hoffman has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

192 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 4.7
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

29 Patient Comments

Reviewed on May 14, 2024

Like her very much or wouldn't come back

Reviewed on May 9, 2024

Dr Hoffman-informal but very professional! Listened, responded, and didn't rush our first visit. I look forward to working with her in the future.

Reviewed on May 9, 2024

We have had wonderful experiences with Cleveland clinic..Dr Hoffman is one of them

Reviewed on May 7, 2024

Dr Hoffman listened and gave thoughtful responses, took her time with me

Reviewed on May 7, 2024

The coordinated care and the way Dr Hoffman oversees it is amazing

Reviewed on May 1, 2024

Excellent doctor, personable, clever, practical

Reviewed on May 1, 2024

I feel lucky to have Dr. Hoffman as my cardiologist.

Reviewed on Apr 30, 2024

I enjoy speaking with my doctor

Reviewed on Apr 2, 2024

After a lot of time going over my meds at the appointment, I was not supplied all of my meds causing me pain. When I had to challenge the RX person that was with the Doctors, I finally got my meds. This was after going with out and missing two days of these meds.

Reviewed on Mar 26, 2024

Dr. Hoffman is kind and attentive I am sure she is very busy but takes the time to respond to my concerns and question.

Reviewed on Mar 26, 2024

Dr Hoffman is both a caring and excellent doctor. She is decidated and willing to go that extra mile to not only treat your physical well being but also your mental well being, making sure you understand what and why she is using the treatment plan. I'd recommend Dr. Hoffman to anyone,

Reviewed on Mar 11, 2024

Excellent provider

Reviewed on Feb 20, 2024

Dr. Hoffman and staff been outstanding. I appreciate the service.

Reviewed on Jan 25, 2024

Dr Hoffman and the LVAD team are ROCKSTARS

Reviewed on Jan 10, 2024

Dr Hoffman is very sincere and thoughtful. Her communication is excellent and insights are very helpful

Reviewed on Jan 8, 2024

I had a very good experience in my dealings withDr. Kofffman .

Reviewed on Dec 20, 2023

I am so pleased to have Dr. Hoffman. She listens!!

Reviewed on Dec 19, 2023

DR was by far the best I've ever met. The time she took to review my chart, to discuss the issues and her recommendations were spot on.

Reviewed on Dec 8, 2023

Dr Hoffman was outstanding in every way

Reviewed on Dec 6, 2023

Dr Hoffman was tremendous, I couldn't have a better Doctor

Reviewed on Nov 14, 2023

All of them in this appointment were just wonderful, kind and helpful and very encouraging a Dr. Hoffman was very sweet and gave a very good explanation simple enough for even me to understand and get the true feeling of what is wrong with my heart. I was very impressed with all of them the way they handled me and the test. It was painful, but they were so kind and understanding and encouraged me to do my best to get the best reading. I cannot say how much I am so thankful for all of them for being so good to me and helping me.

Reviewed on Nov 14, 2023

The care there was outstanding like I said, the only thing I did not feel good about was the cardiologist doctor, Irwin or Everin, or something like that , he needs a check on his bedside manner. He did not listen. He kept cutting me off, and he poo, poo anything I said about me, knowing how my body feels, and that something was very wrong. He had very strong opinions and I didn't feel they came across with kindness and care, but that did not deter me from saying I had good treatment there, Dr. Vargo was absolutely wonderful and his office was outstanding and taking care of me KATYA, his administrative assistant and his nurse were just wonderful kind patient and truly I so wish they could have surgically fix this and I'd go home with better health but what is wrong they cannot fix, but I went home with calmness and peace in my heart. At least I know what it is and how to live with it and how to face it

Reviewed on Nov 11, 2023

Dr. Karlee Hoffman is an amazing Doctor & human being! I would recommend her to everyone!

Reviewed on Nov 8, 2023

I brag on her all the time. I definitely recommend a lot. I am so thankful for her!

Reviewed on Oct 18, 2023

Dr. Karlee Hoffman has really helped me with my Heart Problems and feeling so much better with living and with her knowledge on everything and getting me on the correct Medications and all . She's the best Cardiologist.

Reviewed on Oct 13, 2023

Dr. Hoffman is the best doctor I've ever had. She is a problem solver and keeps going until there is a solution. I feel so fortunate I was assigned to her care in 2020. She is amazing!

Reviewed on Sep 19, 2023

Usually difficult to arrange visits as I have two doctors I like to see while there. They made this seamless and I really appreciate it.

Reviewed on Aug 23, 2023

Dr. Hoffman is excellent.

Reviewed on Aug 7, 2023

She was so helpful in explaining everything.

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