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Department Center for Neuro-Restoration
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Botulinum Toxin Injections
  • Infusion Therapy
  • Nerve Blocks
  • Occipital Nerve Block
  • Trigger Point Injection
View all 5 Treatment & Services +

Specialty in Diseases & Conditions

  • Chronic Headaches
  • Cluster Headaches
  • Concussion
  • Facial Pain
  • Headaches
  • Menstrual Migraines
  • Migraine Headaches
  • Occipital Headache
  • Occipital Neuralgia
  • Paroxysmal Hemicrania
  • Tension Headaches
  • Thunderclap Headaches
  • Trigeminal Neuralgia
View all 13 Specialties +


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About Payal Soni, MD

Payal Soni MD is a Staff Physician in the Department of Neurology, Center for Neurologic Restoration, Headache and Facial Pain Section at Cleveland Clinic. She is the Medical Director of the Trigeminal Neuralgia service line. She is board certified in Neurology and Headache Medicine.

She received her BS in Biomedical Sciences at the University of South Florida in Tampa, FL. She earned her medical degree from the University of South Florida Morsani School of Medicine in Tampa, FL. She completed her residency and fellowship training at Cleveland Clinic.

Dr. Soni specializes in caring for patients with headache and facial pain disorders. She also performs procedures including onabotulinum toxin injections and nerve blocks to treat certain pain conditions. Dr. Soni is passionate about improving the quality of life of patients suffering with chronic pain conditions through medication management and lifestyle modification. Her clinical interests include trigeminal neuralgia and other cranial neuralgias, migraine, and concussion.

She is member of the American Headache Society and the American Academy of Neurology. She also serves as Associate Program Director for the Neurology Residency Program at Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic Headache Medicine Fellowship
Headache Medicine
Cleveland, OH USA

Residency - Cleveland Clinic
Cleveland, OH USA

Medical Education - University of South Florida College of Medicine
Tampa, FL USA

Undergraduate - University of South Florida
Tampa, FL USA


  • Psychiatry and Neurology - Neurology
Research & Publications

Research & Publications

See publications for Payal Soni, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 10/3/2023, Dr. Soni has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Soni receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • AbbVie, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

92 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.8

11 Patient Comments

Reviewed on Feb 27, 2024

She was very nice and seemed to really care about the problems I was having.

Reviewed on Feb 15, 2024

Very happy with Dr. And visit.

Reviewed on Feb 15, 2024

I wish she didn't had to work so much with the computer because she did t see me and look at me thru the whole meeting .

Reviewed on Jan 30, 2024

Dr. Soni is a fantastic physician who skillfully balances being both incredibly knowledgeable while simultaneously very approachable.

Reviewed on Jan 11, 2024

Dr. Payal Soni, MD is absolutely the finest doctor with an outstanding approach to my care. She is dedicated to getting me headache free. She always includes me in on decisions for my treatment and I respect her approach for my care.

Reviewed on Jan 11, 2024

I have and will always recommend Cleveland Clinic Neurology and Dr. Payal Soni, MD

Reviewed on Jan 4, 2024

Dr. Soni listens. I feel like we have a conversation about my treatment and set goals together.

Reviewed on Jan 4, 2024

I have never had a bad experience at Cleveland Clinic. Dr. Soni is excellent. The nursing assistants are excellent. The front office staff is excellent. They always are pleasant and helpful.

Reviewed on Dec 26, 2023

Dr. Soni has made more progress with my migraines than any other doctor in the last 33 years.

Reviewed on Dec 5, 2023

Best doctor I have ever encountered, in every way.

Reviewed on Sep 27, 2023

My doctor was absolutely amazing, and I cannot say enough great things about this appointment. I felt heard, understood, and helped.

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