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Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English, French, Spanish
Surgeon Yes
Locations Specialties & Treatments

Treatment & Services

  • Acute Fracture Care
  • Arthritic Knee Conditions
  • Arthritis Surgery
  • Arthritis, Surgical And Non Surgical Treatment
  • Arthroplasty
  • Bone Grafting
  • Cartilage Repair
  • Cartilage Transplantation
  • Clinical Trials
  • Complex Primary Hip Arthroplasty
  • Complex Primary Knee Arthroplasty
  • Deformity Correction
  • Fracture
  • Fracture Care
  • Fracture Non-union
  • Fracture Reconstruction
  • General Orthopaedics
  • Hip & Knee Surgery
  • Hip Replacement
  • Hip Revision
  • Hyaluronic acid injections
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation
  • Joint Preservation Center
  • Joint Preserving Hip Surgery
  • Joint Reconstruction
  • Joint Replacement
  • Joint Replacement Of The Knee
  • Knee Arthroplasty
  • Knee Injuries
  • Knee Joint Disorders
  • Knee Ligament Injuries
  • Knee Pain
  • Knee Problems
  • Knee Replacement
  • Knee Revision
  • Knee Surgery
  • Labrum Tears
  • Management Of Early Hip Disease
  • Medical Management of Early Osteoarthritis
  • Medical Orthopaedics
  • Minimally Invasive Hip Joint Replacement
  • Minimally Invasive Knee Joint Replacement
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Non Operative Treatment Of Arthritis, Fractures, Sprains And General Orthopaedics
  • Non Surgical Orthopaedics
  • Non-Operative Adult Orthopaedics
  • Orthobiologics
  • Orthopaedic Care of the Elderly
  • Orthopaedic Medicine
  • Orthopaedic Surgery
  • Orthopaedics
  • Partial Knee Replacement
  • Placental Tissue Matrix (PTM)
  • Platelet Lysate (PL)
  • Platelet Poor Plasma (PPP)
  • Platelet Rich Plasma Injections (PRP)
  • Prevention And Treatment Of Injuries In The Aging Athlete
  • Primary And Revision Joint Replacements
  • Primary And Revision Total Hip Arthroplasty
  • Primary And Revision Total Knee Arthroplasty
  • Reconstructive Surgery
  • Reconstructive Surgery Of The Hip
  • Reconstructive Surgery Of The Knee
  • Regenerative Medicine
  • Resurfacing Total Hip Arthroplasty
  • Revision Hip Arthroplasty
  • Revision Hip Joint Replacement
  • Revision Joint Replacement
  • Revision Knee Arthroplasty
  • Revision Knee Joint Replacement
  • Revision Surgery
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Robotic Assisted Hip Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Robotic Knee and Hip Arthroplasty
  • Robotic Surgery
  • Surgery
  • Surgical Treatment Of Arthritis Of The Hips And Knees
  • Total Hip And Total Knee Replacement
  • Total Joint Replacement
  • Total Knee Replacement
  • Viscosupplementation
  • X-Ray
View all 88 Treatment & Services +

Specialty in Diseases & Conditions

  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Avascular Necrosis
  • Avascular Necrosis Of The Hip
  • Avascular Necrosis Of The Knee
  • Bone Disorders
  • Broken Bones
  • Bursitis
  • Cellulitis
  • Developmental Dislocation of the Hip
  • Developmental Dysplasia of the Hip
  • Femoroacetabular Impingement
  • Fractures
  • Fungal Infections
  • Gout
  • Hip Disorders
  • Hip Dysplasia
  • Hip Fracture
  • Hip Impingement
  • Hip Instability
  • Hip Labral Tears
  • Hip Pain
  • Hip Replacement
  • Internal Derangement of the Knee
  • Joint Disorders
  • Knee Cartilage Injury
  • Knee Fractures
  • Knee Injuries
  • Knee Joint Disorders
  • Knee Ligament Injuries
  • Knee Osteoarthritis
  • Knee Pain
  • Knee Problems
  • Labrum Tears
  • Leg Length Inequality
  • Leg Pain
  • Legg-Calve-Perthes Disease
  • Lower Extremity Deformity
  • Muscle Injuries
  • Musculoskeletal Impairments
  • Musculoskeletal Injuries In Athletes
  • Musculoskeletal Pain
  • Nerve Injuries
  • Orthopaedic Injuries
  • Osteoarthritis
  • Osteoarthritis Of The Hips And Knees In The Elderly
  • Osteonecrosis
  • Osteoporosis
  • Overuse Injuries
  • Painful Deformities
  • Painful Joints
  • Patellofemoral Instability
  • Rheumatoid Arthritis: How to Treat
  • Stress Fractures
  • Tendon Injuries
  • Tendonitis
  • Tennis Elbow (lateral epicondylitis)
View all 58 Specialties +


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About Nicolas Piuzzi, MD



Academic Positions

Associate Investigator (2016 – Present)
Instituto Universitario del Hospital Italiano de Buenos Aires
Buenos Aires, Argentina

Member (2017- Present)
Cochrane Center Instituto Universitario Hospital Italiano (IUHI, Buenos Aires) – Cochrane Argentina
Author: Autologous Bone Marrow and Blood derived Biological Therapies for Bone Healing in Adults. Cochrane Bone, Joint and Muscle Trauma Group (University of Manchester, UK) The Cochrane Collaboration

Member (2018 – Present)
Cleveland Clinic Musculoskeletal Research Center (MSRC)

Member (2018 – Present)
Cleveland Clinic Joint Preservation Center

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Orthopedic Regenerative Medicine and Cellular Therapies
Cleveland, OH USA

Residency - Hospital Italiano de Buenos Aires
Orthopedic Surgery
Buenos Aires,

Medical Education - Universidad del Salvador
Buenos Aires,

Professional Highlights

  • Principal Investigator: A Comparative and Correlative Evaluation of Early to Late Stage Osteoarthritis in Human Knee Cartilage utilizing Clinical and Preclinical MRI Imaging (3T & 7T) with Histopathology and Immunohistochemistry as the Standard. Program of Advanced Musculoskeletal Imaging (PAMI) October 1st, 2018 to October 1st, 2019
  • Protocol: Autologous Bone Marrow and Blood derived Biological Therapies for Bone Healing in Adults. Cochrane Bone, Joint and Muscle Trauma Group – The Cochrane Collaboration 2017

Awards & Honors

  • 2010
    • Honor Graduation – Medical Doctor (GPA: 8.90/10) (3rd highest GPA) UNIVERSIDAD DEL SALVADOR, Buenos Aires, Argentina 2010
    • First place Award - XIV Research meeting Universidad del Salvador for study titled: “Anatomic variations of the popliteal artery and its collaterals”, Buenos Aires Argentina, 2010
    • 2012
      • Accésit Award - XVII Residents Session at the A.A.O.T Orthopedic Argentine Annual meeting Annual Meeting: Awarded for study titled: “Arthroscopic repair of Bankart lesion in athletes”, Buenos Aires, Argentina. December 2-5, 2012
      • 2013
        • Special Mention - Menção especial para o trabalho – Tema Livre Oral – XIX Shoulder and Elbow Latin American meeting. Awarded for study titled: “Non-surgical functional treatment for displaced olecranon fractures in the elderly”, Natal, Brazil. October 24-26, 2013
        • First Place Award POSTER - XIX Congreso de la Asociación del Trauma Ortopedico. [XIX Argentinian Trauma Association Annual meeting]
        • Awarded for study titled:"Penetration in the anterolateral cortical in proximal femur fractures treated with short intramedullary nails: Two Case Report”, Buenos Aires, Argentina. October 17-19, 2013
        • First Place Award Oral Presentation 39th Argentinian Hand Association Annual Meeting – [Asociación Argentina de Cirugía de la Mano. 39 Congreso Argentino de Cirugía de la Mano.] For the study titled: “Non-surgical functional treatment for displaced olecranon fractures in the elderly”, San Luis, Argentina October 13, 2013
        • 2014
          • Annual Award Laboratorio Bagó – for the study titled: “Therapeutic modification of the natural history of osteoarthritis, role of supplements” 51º A.A.O.T.: Orthopedic Argentine Annual meeting - Buenos Aires, Argentina. December 10, 2014
          • 2015
            • First Place Paper Award - Residents Session of the 52º A.A.O.T. Orthopedic Argentine Annual meeting: For study titled: “Clinical and radiological outcomes comparison between total ankle arthroplasty and total ankle arthrodesis for the treatment of posttraumatic ankle osteoarthritis” Buenos Aires, Argentina. December 1-5, 2015
            • AAOS/ORS Biologic Treatments of Orthopaedic Injuries (BTOI) research symposium
            • Selected to participate as a Young Investigator in the symposium November 5-7, 2015, in Rosemont, IL
            • 2016
              • Leading article J Bone Joint Surg Am. 2016 Sep 21;98(18):1511-21: Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis. (doi: 10.2106/JBJS.15.01495.) Piuzzi NS*, Chahla J,* Mitchell JJ, Dean CS, Pascual-Garrido C, LaPrade RF, Muschler GF. (*First co-authors)
              • 2017
                • Young Entrepreneur Award, AAOS/ORS Translating Orthopaedic Technologies into Clinical Practice: Pathways from Novel Idea to Improvements in Standard of Care Research Symposium, Rosemont, IL, May 2017
                • 2017 recipient of the Best Poster Award in "Complications Not Including Infection" category for the poster entitled “Low-Dose Aspirin has Non-Inferior Chemoprophylactic Effect on Venous Thromboembolism after Total Knee Arthroplasty” and presented at the 2017 AAHKS Annual Meeting in Hilton Anatole Hotel, Dallas, TX, November 2-5, 2017
                • 2017 Blue Ribbon Article Award Winner (November/December 2017) Factors Influencing Patients’ Hospital Rating After Total Joint Arthroplasty by Jaydev B. Mistry, MD; Chukwuweike U. Gwam, MD; Morad Chughtai, MD; Anton Khlopas, MD; Prem Ramkumar, MD; Nicolas S. Piuzzi, MD; George Muschler, MD; Steven F. Harwin, MD; Michael A. Mont, MD; Ronald E. Delanois, MD
                • 2018
                  • AAOS Optimizing Clinical Use of Biologics in Orthopaedic Surgery. Selected to participate as a Young Investigator in the symposium February 15-17, 2018, in Stanford, 2018
                  • AAOS/OREF/ORS Clinician Scholar Career Development Program Award-Rosemont, IL - September 27-29, 2018


                  • American Academy of Orthopaedic Surgeons (AAOS)
                  • American Association of Hip and Knee Surgeons (AAHKS)
                  • Orthopaedic Research Society (ORS)
                  • International Cartilage Repair Society (ICRS)
                  • International Society for Cellular Therapy (ISCT)
                  • Mid-America Orthopaedic Association
                  • Asociación Argentina de Ortopedia y Traumatologia (AAOT)
                  • American Medical Association
                  • Member of the workgroup for the AAOS Treatment of Osteoarthritis of the Knee Clinical Practice Guideline – 2018/19 - Department of Research, Quality, & Scientific Affairs, American Academy of Orthopaedic Surgeons
                  • Member of the voting panel for the AAOS Surgical Site Infection Appropriate Use Criteria Voting Panel -2018/19 Department of Research, Quality, & Scientific Affairs, American Academy of Orthopaedic Surgeons
                  • Member of the voting panel for the Appropriate Use Criteria for the Management of Osteoarthrosis of the Hip – 2017 - Department of Research, Quality, & Scientific Affairs, American Academy of Orthopaedic Published December 8, 2017
                  • Member Task Force - Engaging the Orthopaedic Surgeon Project Team – Orthopaedic Research Society 2017
                  • Member of American Physical Therapy Academy (APTA) Clinical Practice Guideline (CPG) for Total Knee Arthroplasty (TKA): Pre and Post-operative Physical Therapist Management for Adults with Osteoarthritis Work Group – 2017/18
                  • Member of Orthopaedic Clinical Research Committee (CRC) – Orthopaedic Research Society (ORS), 2018-2020
                  • Organizing Committee: Signature Series Event of the International Society for Cellular Therapies: “Cellular Therapies for Orthopaedics and Musculoskeletal disease Proven and Unproven Therapies - Promise, Facts and Fantasy”, Montreal, Canada, May 2, 2018
Research & Publications

Research & Publications

See publications for Nicolas Piuzzi, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 6/7/2020, Dr. Piuzzi has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

186 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.7 out of 5
Explains 4.6
Listens 4.5
Courtesy, Respect & Concern 4.7
Patient Rating of Doctor 4.7

26 Patient Comments

Reviewed on Jan 21, 2021

great doctor!

Reviewed on Jan 12, 2021

I felt very comfortable with this physician and his explanation of the process was very clear.

Reviewed on Dec 23, 2020

My doctor did a very good job

Reviewed on Dec 22, 2020

Dr Piuzzi is caring, kind, emphatic, professional and a skilled physician. He ended 5 years of almost constant pain . He is just exactly what we all hope for in our medical professionals and I am incredibly lucky to have found him. The drive from Pittsburgh to Cleveland is 100% worthwhile.

Reviewed on Dec 17, 2020

excellent doctor!

Reviewed on Dec 16, 2020

Dr. Piuzzi and all his staff were wonderful to interact with. They were kind and thoughtful and seemed to really listen.

Reviewed on Dec 8, 2020

Dr.piuzzi and his staff were very professional and caring

Reviewed on Nov 24, 2020

Dr. Puizzi took the time to explain everything and asked me if I had any questions or worries. GREST bedside manners.

Reviewed on Nov 24, 2020

Dr. Piuzzi and his staff have been woderful and a pleasure to be included in the study.

Reviewed on Oct 27, 2020

Dr Piuzzi was terrific!

Reviewed on Sep 23, 2020

Dr. Piuzzi is a wonderful doctor! I am very pleased with my knee surgery and the follow-up!

Reviewed on Sep 23, 2020

Great job! And a wonderful doctor!

Reviewed on Sep 22, 2020

The doctor explained exactly what my surgery would consist of, he even drew me a diagram. I felt like he knew exactly what to do for me

Reviewed on Sep 22, 2020

Thank the doctor's and staff for a good stay

Reviewed on Sep 18, 2020

Each time I called the doctors office before my operations, *Dr. Puzzi office staff was wonderful & very, very kind.

Reviewed on Aug 25, 2020

I thought the doctor asked very pertinent questions and was a great listener. I was extremely impressed.

Reviewed on Jul 29, 2020

the doctor was very thorough in his explanation of my issue, options should the issue progress and actually explained my X-ray

Reviewed on Jul 22, 2020

my visit with dr. piuzzi went very well !! he did a great knee replacement for me !!

Reviewed on Jul 1, 2020

Care provider was excellent through out entire visit.

Reviewed on Jun 24, 2020

Dr. Piuzzi showed interest and concern for me. Discussion and information were clear and helpful. I am pleased and confident with his care, and will return to him if any future care is needed.

Reviewed on May 26, 2020

Dr Piuzzi I feel had a very good understanding of what I need to have done. He was in the process of coming up with a consceptual plan and begin recruiting other specialists, to aid in my situation. I appreciate his efforts.

Reviewed on May 19, 2020

I've had multiple major knee surgeries and Dr. Piuzzi has to be hands down the best Ortho that I have had. He is very thorough and compassionate. I will and have referred people to him.

Reviewed on Apr 14, 2020

I love coming to the clinic. I am always treated very good. Only been once or twice I have been treated bad.Dr Pruzzi has been outstanding. When I had my surgery every one was exceptional. Thank You for all you do.

Reviewed on Mar 10, 2020

Excellent Doctor

Reviewed on Feb 26, 2020

the best doc I've ever had , takes time to listen. to me and explains every thing in detail if I don't understand, thanks doc

Reviewed on Feb 26, 2020

best doc I ever had , I wish all my doc s were like he is

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