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Department Orthopaedic Surgery
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon Yes
Cleveland Clinic Main Campus
Primary Location

Cleveland Clinic Main Campus


Additional Locations

Orthopaedic Surgery

Euclid Medical Office

99 Northline Circle
Euclid, OH 44119

Specialties & Treatments

Treatment & Services

  • Anterior Total Hip Replacement
  • Arthritis Surgery
  • Hip Replacement
  • Hip Revision
  • Hip Surgery
  • Hyaluronic Acid Injections
  • Joint Aspiration
  • Joint Injections
  • Joint Reconstruction
  • Joint Replacement
  • Knee Reconstructive Surgery
  • Knee Replacement
  • Knee Revision
  • Knee Surgery
  • Minimally Invasive Hip Joint Replacement
  • Nonsurgical Treatment of Arthritis
  • Outpatient Knee Replacement
  • Partial Knee Replacement
  • Peripheral Joint Injections
  • Primary Total Hip Arthroplasty
  • Reconstructive Surgery of the Hip
  • Revision Joint Replacement
  • Revision Total Hip Replacement
  • Revision Total Knee Replacement
  • Robotic Assisted Knee Replacement
  • Robotic Assisted Partial Knee Replacement
  • Total Knee Replacement
View all 27 Treatment & Services +

Specialty in Diseases & Conditions

  • Arthritis
  • Arthritis of the Hip
  • Arthritis of the Knee
  • Avascular Necrosis of the Hip
  • Avascular Necrosis of the Knee
  • Hip Dysplasia
  • Hip Instability
  • Hip Pain
  • Joint Disorders
  • Knee Joint Disorders
  • Knee Pain
  • Osteoarthritis of the Hip
View all 12 Specialties +


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About Matthew Deren, MD

Matthew Deren, MD is a board-certified orthopaedic surgeon in the Division of Adult Reconstruction. He specializes in knee and hip replacement surgeries, including direct anterior total hip replacement, robotic-assisted total and partial knee replacements, as well as complex and revision knee and hip replacements. He sees patients at Mentor Hospital, Euclid Hospital and Main Campus. 

Dr. Deren completed his undergraduate studies at Yale University, followed by medical school at the Alpert Medical School of Brown University. He then continued his training with orthopaedic residency at Brown University and Rhode Island Hospital where he received the Haffenreifer Housestaff Excellence Award as one of the best chief residents in the entire medical system. He then completed an orthopaedic trauma fellowship at Brown University and Rhode Island Hospital, followed by a fellowship in Adult Reconstruction at the Cleveland Clinic in 2018. In 2022, Dr. Deren returned to the Cleveland Clinic as a Staff Orthopaedic Surgeon after practicing at the University of Massachusetts School of Medicine. He is currently the Associate Fellowship Director for the Orthopaedic Adult Reconstruction Fellowship. In his free time, he enjoys fishing, hunting, woodworking, and spending time with his family. 

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Adult Reconstructive Surgery
Cleveland, OH

Fellowship - Rhode Island Hospital
Orthopaedic Trauma
Providence, RI

Residency - Rhode Island Hospital
Orthopaedic Surgery
Providence, RI

Medical Education - Brown University
Providence, RI


  • Orthopaedic Surgery

Awards & Honors

  • Distinguished Teacher of the Year Award, University of Massachusetts Orthopedic Surgery Residency Program, 2021
  • Haffenreifer Housestaff Excellence Award, Rhode Island Hospital, 2016
Research & Publications

Research & Publications

See publications for Matthew Deren, MD.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/9/2024, Dr. Deren has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Deren receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • Expert Review, Inc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

280 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.8 out of 5
Explains 4.8
Listens 4.6
Courtesy, Respect & Concern 4.8
Patient Rating of Doctor 4.8

49 Patient Comments

Reviewed on May 30, 2024

Dr. Deren spent a lot of time with me, answered many questions, and put me much more at ease about my future surgery

Reviewed on May 30, 2024

My only issue was the issue with scheduling. My time in Dr. Deren's office exceeded my expectations.

Reviewed on May 29, 2024

Dr Deren took the time to explain in detail how my progress was going and explained what and why he did what he did in my surgery. He also explained what my going forward restrictions would be. I feel that he has my best interest in mind.

Reviewed on May 9, 2024

Dr Deren is a very busy doctor. Would have liked an earlier appointment. But I'm there. I want the best. I'll wait for the best.

Reviewed on May 9, 2024

Dr Daran is very

Reviewed on May 2, 2024

Dr. Deren is thorough, extremely competent, and compassionate.

Reviewed on May 1, 2024

Feeling much better physically and thankful for Dr Deren and all who helped

Reviewed on May 1, 2024

Dr.Deren is excellent and helped me feel at ease when I had concerns about surgery.

Reviewed on Apr 25, 2024

Dr. Deren and Jessica are so caring, professional and understanding.

Reviewed on Apr 17, 2024

Dr. Darren was very good and answering my questions, my only concern is I probably didn't have enough questions for him to answer. He was very willing.

Reviewed on Apr 17, 2024

If there was something that could've been possible, I think the doctor would've liked to have x-rays done for this appointment, and I would agree. Other than that, it was great.

Reviewed on Apr 17, 2024

Dr Daren and Jessica are just the best. Very thorough and informative

Reviewed on Apr 17, 2024

Wonderful experience Dr Deren is very patient and kind.

Reviewed on Apr 17, 2024

Overall a very good follow up visit with Dr Deren after my knee surgery. Dr Deren spent time to answer all my questions and offer advice.

Reviewed on Apr 17, 2024

Doctor Darren is so personal he listens to everything

Reviewed on Apr 17, 2024

This Dr and his office staff is awesome! Always a wonderful greeting. Very attentive and the visit is just very easy.

Reviewed on Apr 17, 2024

Dr. Derren was attentive, and very professional. He and his team did a great job on my knee and I've been very impressed by how well the entire adventure has gone.

Reviewed on Apr 17, 2024

This was my first appointment with Dr. Deren. Because my knee was a complicated case, Dr. Deren was going to present my case to his clinic colleagues at their next meeting.

Reviewed on Mar 14, 2024

Dr. Matthew Deren and his staff are top notch in every respect. The world and healthcare for people would be a far better place if only other physicians and staff practiced similarly as I experienced.

Reviewed on Mar 6, 2024

Dr and team great to work with.

Reviewed on Feb 21, 2024

I was able to see the Dr after my left knee x-ray which was a service done after I initially saw the Dr . I was able to get that service done and return immediately back to his office to have a totally complete appointment

Reviewed on Feb 7, 2024

Dr Deren took the time to explain my options for a complex situation. Proposed a solution and explains the risk. Spoke with confidence that he would be able to get me fixed so I could continue to do the things I enjoy the most.

Reviewed on Jan 11, 2024

Would absolutely recommend Dr. Deren and team to others!

Reviewed on Jan 11, 2024

Dr Deren is amazing!

Reviewed on Jan 3, 2024

Dr Darren and staff were attentive and explanatory

Reviewed on Dec 21, 2023

Dr Deren and his nurse Jessica are the absolute best caregivers. I completely felt cared for and respected during this entire process. They are both assets to the Cleveland Clinic.

Reviewed on Dec 21, 2023

I could not have asked for better care from Dr Deren and his team. Thank you

Reviewed on Dec 20, 2023

Dr Deren makes me feel heard and gives me all the information I need for my situation. I appreciate this care!

Reviewed on Dec 13, 2023

Dr. Deren was very professional and friendly

Reviewed on Nov 9, 2023

Dr. Deren very nice and explained everything.

Reviewed on Nov 9, 2023

Dr. Deren technical skills are excellent. My replaced hip is functioning extremely well. He really listened to me and took the time to answer my questions. I trust his opinion.

Reviewed on Nov 8, 2023

I couldn't be more pleased with my pre-op, day of surgery and post operative care I received Dr Deren and Jessica.

Reviewed on Nov 8, 2023

I have and will continue to recommend Dr. Deren to my friends and aquaintances who need hip or knee surgery. I felt very much at ease while under his care.

Reviewed on Nov 8, 2023

Excellent physician and answered all my questions.

Reviewed on Oct 26, 2023

Dr. M Deren was very professional make time to see me ? That is what Being a Cargiver is all about. You can tell be the inteaction he is a dedicated and skilled physician . Iam very pleaced with the experiance Thanky You very much Dr Deren

Reviewed on Oct 26, 2023

Very confident in the Care and advice dicussed if more care is needed I will contact Dr as we talked about Great service

Reviewed on Oct 9, 2023

Weekends are more difficult for reaching my doctor. Dr Deren and his team has always replied to me at their earliest convenience.

Reviewed on Oct 9, 2023

Very impressed after my first meeting with Dr. Deren. I never felt rushed. He looked me in the eye when speaking to me. Answered my questions and informed me of the possible risks of my surgery. He's warm and personable. I feel confident he will do an excellent job on my knee replacement surgery.

Reviewed on Sep 21, 2023

Dr. Deren was very kind and patient He listened to and responded to all my questions. He was positive and knowledgeable about my next steps with hip replacement surgery.

Reviewed on Sep 7, 2023

Dr Deren took his time explaining everything and answered all of our questions.

Reviewed on Sep 7, 2023

This was my first appointment with Dr. Deren, so its difficult to say how I would rate and recommend him. However my first experience and impressions were very good.

Reviewed on Sep 7, 2023

Dr.Deren was fantastic, he answered all of my concerns, and made me feel at ease, very knowledgeable and made the decision to have my surgeries at the CC an easy one.

Reviewed on Sep 6, 2023

Dr. Deren was very friendly, professional, reassuring and thorough throughout my appointment.

Reviewed on Sep 6, 2023

I would recommend Dr. Deren to anyone.

Reviewed on Sep 6, 2023

Dr. Deren and his nurse Jessica Walford are two of the best!

Reviewed on Aug 31, 2023

Very knowledgeable, answered all my questions. I just think the world of him and his assistant.

Reviewed on Aug 17, 2023

Dr. Deren is probably the best physician I've ever had. He is great at listening to his patients, communicating and educating.

Reviewed on Aug 16, 2023

Dr. Deren is very smart and relaxed in his approach. He listens intently and strives to give answers to your answers that are practical and manageable.

Reviewed on Aug 9, 2023

Dr Deren listens and is very thoughtful. Explains well.

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