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Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Administration of Injectable Medications for Osteoporosis
  • Adult Rheumatology
  • Bone Density Testing
  • Clinical Trials
  • Cortisone Injections
  • Dual Energy X-Ray Absorptiometry (DXA)
  • General Rheumatology
  • Immunoglobulin Infusion
  • Immunology
  • Immunotherapy
  • Infusion Therapy
  • Infusions of Biologic Agents on Site
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation Center
  • Medical Management of Early Osteoarthritis
  • Medication Management
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Musculoskeletal Treatment for Joint Pain
  • Osteoporosis Diagnosis
  • Rheumatology
  • Viscosupplementation
View all 23 Treatment & Services +

Specialty in Diseases & Conditions

  • AIDS
  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Arthritis
  • Arthritis of the Hand
  • Arthritis of the Hip
  • Arthritis of the Knee
  • Arthritis of the Thumb Base
  • Arthritis of the Wrist
  • Autoimmune Disease
  • Autoinflammatory Syndromes
  • Behcet's Disease
  • Benign Hypermobility Joint Syndrome
  • Buerger's Disease
  • Bursitis
  • Calcification Tendinitis
  • Calcinosis
  • Central Nervous System Vasculitis
  • Chondrocalcinosis (Pseudo Gout)
  • Churg-Strauss Syndrome
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryoglobulinemia
  • Dermatomyositis
  • Elbow Arthritis
  • Familial Mediterranean Fever (FMF)
  • Giant Cell Arteritis
  • Gout
  • Gout Arthritis
  • Granulomatosis with Polyangiitis (Wegener’s)
  • Hand Pain
  • Hand Problems
  • Henoch-Schonlein Purpura
  • Hip Disorders
  • Hip Pain
  • HIV
  • Immunodeficiency
  • Immunosuppression
  • Iritis
  • Joint Pain
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Lupus Anticoagulant
  • Lupus Nephritis
  • Metabolic Bone Disease
  • Metabolic Diseases
  • Microscopic Polyangiitis (MPA)
  • Musculoskeletal Disorders
  • Musculoskeletal Impairments
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis
  • Osteopenia
  • Raynaud's Phenomenon
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren's Syndrome
View all 59 Specialties +


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About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Internal Medicine - Rheumatology
  • Internal Medicine - Infectious Disease

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/7/2023, Dr. Calabrese has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Calabrese receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • AstraZeneca

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

156 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 5
Patient Rating of Doctor 4.9

43 Patient Comments

Reviewed on Oct 20, 2023

Excellent doctor, great with patients, extremely competent and knowledgeable and courteous.

Reviewed on Oct 17, 2023

Dr Calabrese is the definition of professional

Reviewed on Oct 17, 2023

I have recommended Dr Calabrese to others because of her thoroughness and her Greta listening ability

Reviewed on Aug 25, 2023

Dr Calabrese was very welcoming, warm, reassuring and knowledgeable.

Reviewed on Aug 17, 2023

I just love Dr. Calabrese, her attentiveness and care to my medical situation. She always checks everything and talks to me in depth about what I have going on medically. She is a kind and caring doctor.

Reviewed on Aug 16, 2023

After trying to schedule with 2 other rheumatologist, I got an appt with Dr. Calabrese. I called in January and got an appt for August-7 months later.

Reviewed on Aug 16, 2023

Dr. Calabrese was friendly and interested in getting to know me. She was informative and caring.

Reviewed on Aug 15, 2023

Dr. C. Clarabrese was outstanding. From the moment she walked into the patient's room she was responsive to our needs and concerns. Her communication skills were excellent, she was thorough and attentive and made me a part of the decision making process.

Reviewed on Aug 9, 2023

Dr. Calabrese is very personable, knowledgeable, kind and caring.a credit to her profession and an asset to the Clinic.

Reviewed on Aug 1, 2023

Dr C was amazing . She took her time and not only listened to me but heard me . She did something no one has done for me since the long Covid symptoms started . She gave me hope and a plan . She truly is an amazing provider .

Reviewed on Jul 25, 2023

Dr. Cassandra is the best.

Reviewed on Jul 18, 2023

Dr Calabrese listened to my concerns, explained to me what was going on, my diagnosis and my options were for treatment and treated me with professionalism, caring and left me feeling positive.

Reviewed on Jul 18, 2023

I always recommend Dr Calabrese and Cleveland Clinic to others in need.

Reviewed on Jul 14, 2023

Because when I come I bring my daughters, the doctor always includes them in every plan of action that is needed for my care, if there is something I may not remember my daughter is always the one to remind me, about the care plan or conversation of starting a care plan the doctor discussed with me.

Reviewed on Jul 14, 2023

Dr Calabrese is an excellent doctor.

Reviewed on Jul 11, 2023

Dr. Calabrese is always such a good listener about what the patient is saying and extremely concerned!

Reviewed on Jun 23, 2023

I really felt she listened to my concerns and took them seriously. She was caring. She made me feel validated.

Reviewed on Jun 16, 2023

Doctor C. Calabrese is an asset to the CC. She has went above and beyond for me and her care and compassion are off the charts!!

Reviewed on Jun 15, 2023

Best Doctor I have ever met

Reviewed on Jun 9, 2023

Dr. Calabrese is very thorough, pleasant, reassuring that I am receiving the best care possible. I thoroughly trust her and her guidance.

Reviewed on Jun 6, 2023

Dr. C. Calabrese is kind, honest and professional.

Reviewed on May 19, 2023

Dr Calabrese is my favorite doctor. She's always attentive and caring.

Reviewed on May 16, 2023

Dr. Calabrese was the best doctor I ever came encounter with, she was great!

Reviewed on May 9, 2023

Dr calabrese is always very professional and compassionate

Reviewed on May 9, 2023

I have never had a bad experience with Dr Calabrese. She is always willing to help and shows great concern for any issues at hand.

Reviewed on Apr 12, 2023

Dr. Calabrese was very kind, compassionate and for the first time in a very long time as a Clinic patient I felt heard. She did not blow off my health concerns like I'm used to doctors doing. She listened attentively and formed a plan of action for my care moving forward. She is an excellent example of how a physician should be.

Reviewed on Apr 12, 2023

Excellent provider. Kind, caring and understands complex nature of my issues.

Reviewed on Apr 6, 2023

Dr Calabrese is an excellent physician! I cannot say enough about her kindness compassion and ability to listen. As a patient looking for answers, her knowledge and experience helped save my quality of life. My family and I are grateful for her care and concern!

Reviewed on Apr 5, 2023

I recently called Dr. Calabrese's office for advice when I contracted Covid. Dr. Calabrese herself called back within the hour and provided medical treatment.

Reviewed on Apr 4, 2023

Dr. Calabrese really listened.

Reviewed on Mar 31, 2023

Dr. Calabrese is always top notch! I feel well cared for.

Reviewed on Mar 22, 2023

Dr Calabrese offered pro-active options for my health concerns which I appreciated.

Reviewed on Mar 14, 2023

Good provider and knowledgeable but she relies too much on checklists and missed several key features indicative of a condition that she said she had a low suspicion for.

Reviewed on Mar 10, 2023

She shows genuine concern and never makes me feel rushed or ignored. All of my concerns are always addressed and she even pulls concerns out I didn't realize I had. She is outstanding.

Reviewed on Mar 7, 2023

Dr. Calabrese is great. Well worth the 500 mile drive!

Reviewed on Mar 2, 2023

Dr. Cassandra Calabrese is consistently outstanding

Reviewed on Feb 15, 2023

Great doctor!

Reviewed on Feb 7, 2023

Dr. Cassandra Calabrese is always kind, compassionate, and interested in knowing how she can help me.

Reviewed on Jan 24, 2023

Dr. C Calabrese was amazing! Great bedside manner, concerned, comforting, definitive, respectful, kind, courteous, very smart and really good at what she does! She was a pleasure to be around and I am thankful I had the opportunity to be seen by her.

Reviewed on Jan 10, 2023

I am completely satisfied with Dr calabrese's patient care. She's engaging, kind, listens and for me I feel she's very caring.

Reviewed on Dec 23, 2022

This televisit was very welcomed! Dr Calabrese's office called the day before asking if we'd mind doing a televisit due to the bad snow storm scheduled to hit us the next day. Couldn't thank them enough for thinking of us! We live an hour and a half away!

Reviewed on Dec 7, 2022

I have had several visits with Dr Calabrese and all have been very good.

Reviewed on Dec 7, 2022

Dr Calabrese is always helpful and concerned

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