alert icon Coronavirus

Think you may have COVID-19?
Find out where you can get tested

Need a vaccine or booster?
Schedule today

Coming to a Cleveland Clinic location?
Nonessential surgeries postponed in Ohio through Jan. 30
Visitation and mask requirements

Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Administration Of Injectable Medications For Osteoporosis
  • Arthritic Knee Conditions
  • Bone Density Testing
  • Clinical Trials
  • Cortisone injections
  • Diagnosis of Osteoporosis
  • Dual Energy X-ray Absorptiometry (DXA)
  • General Rheumatology
  • General Rheumatology including Lupus
  • Immunoglobulin Infusion
  • Immunology of Infectious Diseases
  • Immunotherapy
  • Infusion Therapy
  • Infusions Of Biologic Agents On Site
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation Center
  • Medical Management of Early Osteoarthritis
  • Medication Management
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Musculoskeletal Treatment For Joint Pain
  • Rheumatology
  • Viscosupplementation
View all 24 Treatment & Services +

Specialty in Diseases & Conditions

  • Adult Rheumatology
  • AIDS & HIV
  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis of the Foot and Ankle
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Arthritis of the Thumb Base
  • Arthritis of the Wrist & Hand
  • Autoimmune Disease
  • Autoinflammatory Syndromes
  • Behcet's Disease
  • Benign Hypermobility Joint Syndrome
  • Buerger's Disease
  • Bursitis
  • Calcification Tendinitis
  • Calcinosis
  • Central Nervous System Vasculitis
  • Chondrocalcinosis (Pseudo Gout)
  • Churg-Strauss Syndrome
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryoglobulinemia
  • Dermatomyositis
  • Elbow Arthritis
  • Familial Mediterranean Fever
  • Familial Mediterranean Fever (FMF) Syndrome
  • Foot & Ankle Arthritis
  • Giant Cell Arteritis
  • Gout
  • Gout Arthritis
  • Granulomatosis with Polyangitis (Wegener’s)
  • Hand and Wrist Arthritis
  • Hand Pain
  • Hand Problems
  • Henoch Schonlein Purpura
  • Hip Arthritis
  • Hip Disorders
  • Hip Pain
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Iritis
  • Joint Pain
  • Knee Arthritis
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Lupus Anticoagulant
  • Lupus Nephritis
  • Metabolic Bone Disease
  • Metabolic Diseases
  • Microscopic Polyangiitis (MPA)
  • Musculoskeletal Disorders
  • Musculoskeletal Impairments
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis
  • Osteopenia
  • Raynaud's Phenomenon
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren's Syndrome
View all 66 Specialties +


Is Cleveland Clinic Part of Your Insurance?

Review a list of accepted insurance plans for our Northeast Ohio locations or learn more about purchasing a contracted managed care plan.

View All Plans

About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Internal Medicine - Rheumatology
  • Internal Medicine - Infectious Disease

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 7/7/2021, Dr. Calabrese has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Calabrese receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Sanofi Genzyme

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

191 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 5
Patient Rating of Doctor 4.9

44 Patient Comments

Reviewed on Oct 20, 2021

Dr Calabrese is great! She is always professional, yet friendly and always makes you feel comfortable when discussing your health.

Reviewed on Oct 13, 2021

Dr. Calabrese was wonderful. She was able to work me into her schedule and around my very complicated schedule.

Reviewed on Oct 13, 2021

Dr. Calabrese and the staff were extremely helpful and professional.

Reviewed on Oct 8, 2021

Dr Calabrese was excellent

Reviewed on Sep 7, 2021

This was a very positive experience. Dr. Calabrese was extremely nice and very knowledgeable.

Reviewed on Sep 7, 2021

Dr. Calabrese was wonderful. She listened to me and explained everything clearly.

Reviewed on Sep 1, 2021

Dr Calabrese listens to me, cared about what I have to say, makes sure I understand everything about my care and listens to my input.

Reviewed on Aug 26, 2021

I have multiple medical problems and'm very blessed to have Dr. Calabrese on my team.

Reviewed on Aug 24, 2021

I am extremely happy with Dr. Calabrese

Reviewed on Aug 24, 2021

I would recommend Dr Calabrese, she has taken good care of me and helped to ease my pain.

Reviewed on Aug 13, 2021

My experiences with Dr. Calabrese have always been proactive, enlightening and personal yet professional.

Reviewed on Aug 12, 2021

I would highly recommend Doctor Calabrese and the Cleveland Clinic

Reviewed on Aug 11, 2021

The Dr. Was amazing!!

Reviewed on Aug 6, 2021

Doctor Cassandra Calabrese is an amazing doctor and is very personable and always puts me first. She is a huge asset to the CC!

Reviewed on Aug 6, 2021

Dr. Calabrese is fantastic with her communication skills with her patients. She is extremely prompt!

Reviewed on Aug 6, 2021

Dr. Calabrese is genuinely concerned about "you" as a patient. She LISTENS carefully as one explains the reason for the visit. She always includes you in her decisions and explains WHY! She is a compassionate , caring , and knowledgeable!!!

Reviewed on Aug 3, 2021

Dr. Calebprese was very informing and helpful.

Reviewed on Jul 2, 2021

This was my first visit to Cleveland Clinic and with Dr Cassandra was a good experience.

Reviewed on Jun 24, 2021

Dr. Calabrese is the perfect blend of compassion, intellect and communication. She is smart, she's a great problem-solver and insists we get to the bottom of current issues. She has been an emphatic advocate who has helped move along the process of getting answers from appropriate specialists and imaging. Her recommendations and comments have helped guide my internist to make the appropriate referrals in a more timely manner. I am lucky to have her partnering with Dr. Fernandez to provide me world-class, smart, and kind, compassionate care.

Reviewed on Jun 15, 2021

Dr Calabreese walks on water! She is the best of the best on every category! We hope you appreciate her . She made our day and continues to surprise us with her outstanding service and commitment. God bless her. Very Sincerely

Reviewed on Jun 8, 2021

Dr. and staff have been wonderful to so happy for Dr. Calabrese to receive me as a new patient. .formally was a first time patient of her Father in 2003...

Reviewed on Jun 8, 2021

great doctor!

Reviewed on May 28, 2021

Dr Calabrese is knowledgeable, professional and caring. I trust her. She is an excellent listener !! She does not type on the computer and ignore me (like too many doctors). Dr Calabrese is exceptional, a real diamond.

Reviewed on May 21, 2021

I have said this before. The dr. Is professional, asks if any other areas of my body have issues. Walking, etc. She cares.

Reviewed on May 11, 2021

I cannot say enough good about Dr. Calabrese. She is a very caring and attentive doctor. I'm lucky to have her.

Reviewed on Apr 30, 2021

Can't say enough about Doctor Cassie . She has been amazing and beyond helpful with anything I need. She is amazing!!!!!

Reviewed on Apr 23, 2021

Doctor Calabrese is a very kind and compassionate individual.

Reviewed on Apr 13, 2021

Cleveland Clinic and Dr. Calabrese are both excellent !!!

Reviewed on Apr 7, 2021

I love dr Calabrese!

Reviewed on Apr 6, 2021

I am very happy with Doctor Calabrese.

Reviewed on Apr 2, 2021

Dr. Calabrese made me feel like she truly cared about my illness. Her bed side manners was perfect.

Reviewed on Mar 24, 2021

Really appreciate Dr. Calebrese. She is a great listener, very responsive and I trust her.

Reviewed on Mar 23, 2021

Dr Calabrese is awesome. Nothing but the best from her.

Reviewed on Mar 19, 2021

Dr Calabrese was extremely thoughtful and supportive - she took a great deal of time to explain possible issues and solutions

Reviewed on Feb 19, 2021

Dr. Calabrese seemed very committed to finding answers for my symptoms and genuinely determined to ensure I could be as comfortable as possible in the interim.

Reviewed on Feb 5, 2021

My dr. always asks just how I am. She listens to my description of my ability for movement, pain, or the movement I m having. She was concerned over my husbands conditions, my health, progress I'm making. She is very sincere over my care. I have never had a dr. Like her. She is a treasure to have.

Reviewed on Feb 1, 2021

Dr. Calabrese is a gem, she helped set up the visit. She really cares

Reviewed on Feb 1, 2021

Dr. C Calabrese has a superb way of interacting with patients. She is kind, compassionate and caring. She is one of the most empathetic physicians I have ever encountered. All new physicians should be required to watch her in action to learn how to talk to patients and get a history. Even more remarkable was that she was able to do this as a video visit for a new patient. I am blown away by her skill and expertise

Reviewed on Jan 22, 2021

doctor Calabrese has been amazing. I travel from Buffalo to see her 4 times a year. she is the best!!!! very professional and always putting my needs first. very accommodating because I am from out of town. helped me tremendously!!!!

Reviewed on Jan 22, 2021

I will continue to come to the CC as long as my insurance allows me too. great hospital and great doctors!!!!

Reviewed on Jan 21, 2021

Dr Calabrese is veryaccommodating in regards to coordinating appointment times.

Reviewed on Jan 21, 2021

Dr. Calabrese is veryrespectful and has such a caring and professional demeanor.

Reviewed on Jan 6, 2021

Dr Calabrese is always accommodating.

Reviewed on Jan 6, 2021

I highly recommend Dr. Calabrese. She is awesome! I'm complex with multiple immune mediated issues. She listens to my issues and truly has empathy and tries to help. If she believes a problem is outside of her expertise, she will explain why and refer to someone who can. Excellent communication skills and has never made me feel silly for asking questions.

Related Videos Featuring Cassandra Calabrese, DO

Related Videos Featuring Cassandra Calabrese, DO

Back to Top