Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Bone Density Testing
  • Hyaluronic acid injections
  • Immunology of Infectious Diseases
  • Immunotherapy
  • Infusion Therapy
  • Infusions Of Biologic Agents On Site
  • Joint Aspiration
  • Joint Injections
  • Medication Management
  • Rheumatology
  • Viscosupplementation
View all 11 Treatment & Services +

Specialty in Diseases & Conditions

  • Adult Rheumatology
  • AIDS & HIV
  • Ankylosing Spondylitis
  • Bursitis
  • Connective Tissue Disorders
  • Gout
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Myositis
  • Osteoarthritis
  • Osteopenia
  • Raynaud's Phenomenon
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren's Syndrome
View all 17 Specialties +


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About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Rheumatology
  • Infectious Diseases

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 5/8/2020, Dr. Calabrese has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

147 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 5
Patient Rating of Doctor 4.9

43 Patient Comments

Reviewed on Jan 31, 2020

At the end of the appt dr Calabrese always ask ksasif thereis anything else shecoulddo or answer for us. This is so wonderful because I've had strokes andi it takes me time to process each question and I don't feel rushed.

Reviewed on Jan 31, 2020

my first appointment with dr calabrese I was stressed and in physical pain and started to cry. she was very consoling without being patronizing. I've seen many specialist over 28 years of r dealing with rare autoimmune diseases. dr Calabrese treats you with human kindness which means everything to patients struggling to cope. more should follow her examples of kindness

Reviewed on Jan 3, 2020

Dr. Calabrese is the best doctor I have ever had. I have had many doctors.

Reviewed on Dec 31, 2019

Dr. Calabrese and Cleveland did a wonderful job!

Reviewed on Dec 11, 2019

a caring person and physician

Reviewed on Dec 3, 2019

Dr. Calabrese had very good bedside manners with me and took her time to explain all my symptoms. She has also kept in touch with my daughter due to a lack of English on my end.

Reviewed on Nov 27, 2019

Dr. Calabrese provides exemplary care! The reasons why I believe this is because she is caring go, attentive to all of the patient's needs, and is prompt in answering patient's concerns and questions!

Reviewed on Nov 27, 2019

Dr. Calabrese's is definitely a doctor that truly cares about how the patient feels and will be an advocate for the patient!

Reviewed on Nov 15, 2019

My experience with doctor Calabrese has been amazing. She is very knowledgeable and is truly concerned for her patients. She always answers me back promptly when I reach out to her on the Portal. Living in NY it's great that she responds right away.....

Reviewed on Nov 14, 2019

Dr Calabrese was very caring and made sure I understood everything she was explaining about my condition and treatment plan. she listened to me.

Reviewed on Nov 1, 2019

I think very highly of Dr Cassie Calabrese...

Reviewed on Oct 22, 2019

It is easy to message Dr. Calabrese, and I always get a quick response.

Reviewed on Oct 16, 2019

I was extremely early and the doctor or squeezed me in.

Reviewed on Oct 16, 2019

Very happy with Dr Calabrese

Reviewed on Sep 27, 2019

Dr. Calabrese has been very responsive to my PMR related healthcare needs. She is thorough and patient during office visits. Responsive to questions, and very pleasant. I've sent her several post-visit follow-up questions via My Chart, and she has consistently answered them very promptly. I've been extremely pleased with all aspects of my care at the Arthritis Center with Dr. Calabrese.

Reviewed on Sep 13, 2019

The experience I had with DO Calabrese was great. I had my 2 daughters with me at the time. She took the time to fill them in on my case so they knew what was going on. I truly think she has my best interest at heart. she took a minute to say hello as we walked back to the room. My daughters thought she was very sincere about my condition & treatment. I wish other dr.s showed the same amount of care that was giving to me on this day. I give her 5 stars. 5 being the highest.

Reviewed on Sep 13, 2019

Dr Cassandra Calabrese is a wonderful doctor, always makes me feel comfortable, listens and explains options well. She's very thorough. I just love her. Can not say enough good things about her. She is wonderful, caring, thorough, compassionate. . .she's GREAT!

Reviewed on Aug 16, 2019

dr Calabrese is the most caring, understanding doctor I've ever had. she has gone above and beyond for me and made sure I knew she was doing her job and that she believed me about my health. she spent the necessary time without rushing me and made sure to schedule the next appt so that I didn't have to deal with not being able to get one. I've never met a better doctor

Reviewed on Aug 9, 2019

Dr Calabrese is Great and very concerned

Reviewed on Aug 2, 2019

I have seen many md's over the period of my life, most were very good to excellent. Dr. Calebrese is the best physician I have ever dealt with. She gave me time to give my history, responded to my concerns, and I felt worked with me to find treatment that both would be effective for me and within my comfort range. I left the office having no topic that I would like to have had more opportunity to go over. I found her to be both very professional and very compassionate.

Reviewed on Aug 2, 2019

This is the 13th doctor I've seen. and the only one that has asked me questions, listened, and been empathetic. and incredible experience start to finish.

Reviewed on Aug 1, 2019

Dr Calabrese takes time to listen to me, answers all my questions, explaining and making sure I understand, what and why regarding my treatment and/or any new testing. She is very professional and stays in contact to give me any additional information when test results come in and has helped to refer me to another specialist I need. I always recommend her to anyone I know needing a doctor in her field.

Reviewed on Jul 26, 2019

Dr. Calabrese is a very caring doctor.

Reviewed on Jul 23, 2019

Dr. Calabrese is is the best. She's totally in tune with your concerns and follows through on every level. She's so personable that you truly feel like you're having a sincere one on one with no fail from one appointment to the next. I'd rate her with a hundred stars!

Reviewed on Jul 12, 2019

I have had a very good response with Dr Calabrese, she is very thorough and listens attentively to the problems that you are facing with your arthritis. I like her very much.

Reviewed on Jul 3, 2019

Dr. Calabrese is my Dr. at the clinic. she is very easy to talk to and takes her time explains treatment options. I've always heard back from her when messaging questions and concerns. I would highly recommend her.

Reviewed on Jul 2, 2019

Dr.Cassandra Calabrese is wonderful! Compassionate, takes her time explaining medical issues and has been very beneficial in my treatment

Reviewed on Jun 19, 2019

I am completely impressed with Dr Calabrese's knowledge and beside manner. She validated my symptoms, which helps my anxiety.

Reviewed on May 22, 2019

Informative, listened well, asked questions and cared about the answers, thorough examination, provided options, included me in the decision making process for moving forward. Dr. Calabreeze's calm demeanor created an environment which didn't feel rushed but reassured me that answers would be found and treatment provided to improved daily life.

Reviewed on May 9, 2019

Cassie Calabrese is an outstanding doctor...I like to refer to her as a "rock star" because of her two specialties that directly impact my health...I truly hope she remains my doc

Reviewed on May 8, 2019

Dr. Calabrese was wonderful. She was prepared, prompt and thorough!

Reviewed on May 8, 2019

Dr. Calabrese was wonderful. she was prepared, prompt and thorough.

Reviewed on Apr 25, 2019

Dr Calabrese was professional, informative, caring and listened. she took time to explain what to expect, and possible side effects along with all the benefits of the injection.

Reviewed on Apr 17, 2019

Dr. Calabrese is absolutely amazing. I am blessed to have been able to transfer my care to her. She is extremely knowledge and caring.

Reviewed on Apr 12, 2019

She was a very thorough doctor and I will definitely be coming back to her.

Reviewed on Mar 29, 2019

Dr. Calabrese is outstanding in every regard. She encourages messaging, if needed, and noticeably prompt responding.

Reviewed on Mar 27, 2019

Dr. Calabrese is especially good communicating via the website.

Reviewed on Mar 20, 2019

Dr Calabrese is very caring and positive. ...which is comforting

Reviewed on Mar 15, 2019

I love Dr. Calabrese so much. She answers within a few minutes whenever I call or mychart her. She always makes sure to answer all questions I have. She is always apologetic (even though it's not her fault) if I am having any issues. She is the best!!!

Reviewed on Mar 6, 2019

I have worked with hundreds of doctors during my career as a nurse. Dr. Calabrese is one of the most intelligent, caring doctors I have ever met.

Reviewed on Feb 22, 2019

Very caring and compassionate. Dr. Calabrese is wonderful. She listens to you, remembered progress from last visit and made me feel like I was her only patient. Better yet, her treatment plan she put me on seems to be working! I can't say enough great things about her. Great physician and person!

Reviewed on Feb 22, 2019

Dr. Calabrese was extremely empathetic, comforting, and genuine!! I felt so at ease and respected with her!

Reviewed on Feb 13, 2019

Dr. Calabrese was excellent! My mom and I met her for a potential serious concern I had. she was extremely patient, understanding and knowledgeable. We then stayed in contact via MyChart for a few days as I was receiving lab results back. she was always very quick to respond and explained everything in detail. highly recommend Dr. Calabrese!

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