Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No


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About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Rheumatology
  • Infectious Diseases

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 5/13/2019, Dr. Calabrese has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Calabrese receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • GlaxoSmithKline plc.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

136 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Listens 5
Courtesy, Respect & Concern 4.9
Knows Medical History 4.8
Time Spent with Patient 5
Patient Rating of Doctor 4.8

26 Patient Comments

Reviewed on Jul 26, 2019

Dr. Calabrese is a very caring doctor.

Reviewed on Jul 12, 2019

I have had a very good response with Dr Calabrese, she is very thorough and listens attentively to the problems that you are facing with your arthritis. I like her very much.

Reviewed on Jul 3, 2019

Dr. Calabrese is my Dr. at the clinic. she is very easy to talk to and takes her time explains treatment options. I've always heard back from her when messaging questions and concerns. I would highly recommend her.

Reviewed on Jul 2, 2019

Dr.Cassandra Calabrese is wonderful! Compassionate, takes her time explaining medical issues and has been very beneficial in my treatment

Reviewed on Jun 19, 2019

I am completely impressed with Dr Calabrese's knowledge and beside manner. She validated my symptoms, which helps my anxiety.

Reviewed on May 22, 2019

Informative, listened well, asked questions and cared about the answers, thorough examination, provided options, included me in the decision making process for moving forward. Dr. Calabreeze's calm demeanor created an environment which didn't feel rushed but reassured me that answers would be found and treatment provided to improved daily life.

Reviewed on May 9, 2019

Cassie Calabrese is an outstanding doctor...I like to refer to her as a "rock star" because of her two specialties that directly impact my health...I truly hope she remains my doc

Reviewed on May 8, 2019

Dr. Calabrese was wonderful. She was prepared, prompt and thorough!

Reviewed on May 8, 2019

Dr. Calabrese was wonderful. she was prepared, prompt and thorough.

Reviewed on Apr 25, 2019

Dr Calabrese was professional, informative, caring and listened. she took time to explain what to expect, and possible side effects along with all the benefits of the injection.

Reviewed on Apr 17, 2019

Dr. Calabrese is absolutely amazing. I am blessed to have been able to transfer my care to her. She is extremely knowledge and caring.

Reviewed on Apr 12, 2019

She was a very thorough doctor and I will definitely be coming back to her.

Reviewed on Mar 29, 2019

Dr. Calabrese is outstanding in every regard. She encourages messaging, if needed, and noticeably prompt responding.

Reviewed on Mar 27, 2019

Dr. Calabrese is especially good communicating via the website.

Reviewed on Mar 20, 2019

Dr Calabrese is very caring and positive. ...which is comforting

Reviewed on Mar 15, 2019

I love Dr. Calabrese so much. She answers within a few minutes whenever I call or mychart her. She always makes sure to answer all questions I have. She is always apologetic (even though it's not her fault) if I am having any issues. She is the best!!!

Reviewed on Mar 6, 2019

I have worked with hundreds of doctors during my career as a nurse. Dr. Calabrese is one of the most intelligent, caring doctors I have ever met.

Reviewed on Feb 22, 2019

Very caring and compassionate. Dr. Calabrese is wonderful. She listens to you, remembered progress from last visit and made me feel like I was her only patient. Better yet, her treatment plan she put me on seems to be working! I can't say enough great things about her. Great physician and person!

Reviewed on Feb 22, 2019

Dr. Calabrese was extremely empathetic, comforting, and genuine!! I felt so at ease and respected with her!

Reviewed on Feb 13, 2019

Dr. Calabrese was excellent! My mom and I met her for a potential serious concern I had. she was extremely patient, understanding and knowledgeable. We then stayed in contact via MyChart for a few days as I was receiving lab results back. she was always very quick to respond and explained everything in detail. highly recommend Dr. Calabrese!

Reviewed on Jan 18, 2019

Dr. Calabrese was very concerned over my health/reason for coming to the Clinic. She was excellent in explaining what tests needed to be done, why, and what the attack will be. I've never had a dr. so upbeat, caring, asking about my medical history, how I feel, when are their issues, etc. I'm very impressed and lucky to have had her examine me. THEN the personal phone call made to me to discuss my xrays and blood tests--she was wonderful. What a lucky patient I am to have her as my dr. WOW!!!

Reviewed on Jan 4, 2019

Dr Calabrese always takes time to make sure I understand, listens to me, asks my opinion,

Reviewed on Dec 18, 2018

terrific health care provider. ..very empathic. ..almost like talking to a friend.

Reviewed on Dec 18, 2018

Dr. Calabrese was the best thing that has happened to me. I can't say how pleased I am with the appointment I had. She listened to me and educated me on my health. I am so glad she is now my Rhuemotologist.

Reviewed on Dec 12, 2018

Dr. Calabrese is great! She is always receptive to what I tell her and takes the course of action that is right for me. She responds very quickly on MyChart and she's probably one of the best doctors I've seen.

Reviewed on Oct 9, 2018

Dr Calabrese has been excellent in her attention to my care, considering my wishes in choosing the path of my care and communicating with me when I have concerns.

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