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Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Administration Of Injectable Medications For Osteoporosis
  • Adult Rheumatology
  • Arthritic Knee Conditions
  • Bone Density Testing
  • Clinical Trials
  • Cortisone injections
  • Diagnosis of Osteoporosis
  • Dual Energy X-ray Absorptiometry (DXA)
  • General Rheumatology
  • General Rheumatology including Lupus
  • Immunoglobulin Infusion
  • Immunology of Infectious Diseases
  • Immunotherapy
  • Infusion Therapy
  • Infusions Of Biologic Agents On Site
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation Center
  • Medical Management of Early Osteoarthritis
  • Medication Management
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Musculoskeletal Treatment For Joint Pain
  • Rheumatology
  • Viscosupplementation
View all 25 Treatment & Services +

Specialty in Diseases & Conditions

  • AIDS & HIV
  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Arthritis of the Thumb Base
  • Arthritis of the Wrist & Hand
  • Autoimmune Disease
  • Autoinflammatory Syndromes
  • Behcet's Disease
  • Benign Hypermobility Joint Syndrome
  • Buerger's Disease
  • Bursitis
  • Calcification Tendinitis
  • Calcinosis
  • Central Nervous System Vasculitis
  • Chondrocalcinosis (Pseudo Gout)
  • Churg-Strauss Syndrome
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryoglobulinemia
  • Dermatomyositis
  • Elbow Arthritis
  • Familial Mediterranean Fever
  • Familial Mediterranean Fever (FMF) Syndrome
  • Giant Cell Arteritis
  • Gout
  • Gout Arthritis
  • Granulomatosis with Polyangitis (Wegener’s)
  • Hand and Wrist Arthritis
  • Hand Pain
  • Hand Problems
  • Henoch Schonlein Purpura
  • Hip Arthritis
  • Hip Disorders
  • Hip Pain
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Iritis
  • Joint Pain
  • Knee Arthritis
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Lupus Anticoagulant
  • Lupus Nephritis
  • Metabolic Bone Disease
  • Metabolic Diseases
  • Microscopic Polyangiitis (MPA)
  • Musculoskeletal Disorders
  • Musculoskeletal Impairments
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis
  • Osteopenia
  • Raynaud's Phenomenon
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren's Syndrome
View all 63 Specialties +


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About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Internal Medicine - Rheumatology
  • Internal Medicine - Infectious Disease

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/7/2023, Dr. Calabrese has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Calabrese receives fees of $5,000 or more per year (or, in rare cases, equity or stock options) as a paid consultant, speaker or as a member of an advisory committee for the following companies:

  • AstraZeneca

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

120 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
5 out of 5
Explains 4.9
Courtesy, Respect & Concern 5
Patient Rating of Doctor 5

37 Patient Comments

Reviewed on May 9, 2023

Dr calabrese is always very professional and compassionate

Reviewed on Apr 12, 2023

Dr. Calabrese was very kind, compassionate and for the first time in a very long time as a Clinic patient I felt heard. She did not blow off my health concerns like I'm used to doctors doing. She listened attentively and formed a plan of action for my care moving forward. She is an excellent example of how a physician should be.

Reviewed on Apr 12, 2023

Excellent provider. Kind, caring and understands complex nature of my issues.

Reviewed on Apr 6, 2023

Dr Calabrese is an excellent physician! I cannot say enough about her kindness compassion and ability to listen. As a patient looking for answers, her knowledge and experience helped save my quality of life. My family and I are grateful for her care and concern!

Reviewed on Apr 5, 2023

I recently called Dr. Calabrese's office for advice when I contracted Covid. Dr. Calabrese herself called back within the hour and provided medical treatment.

Reviewed on Apr 4, 2023

Dr. Calabrese really listened.

Reviewed on Mar 31, 2023

Dr. Calabrese is always top notch! I feel well cared for.

Reviewed on Mar 22, 2023

Dr Calabrese offered pro-active options for my health concerns which I appreciated.

Reviewed on Mar 14, 2023

Good provider and knowledgeable but she relies too much on checklists and missed several key features indicative of a condition that she said she had a low suspicion for.

Reviewed on Mar 10, 2023

She shows genuine concern and never makes me feel rushed or ignored. All of my concerns are always addressed and she even pulls concerns out I didn't realize I had. She is outstanding.

Reviewed on Mar 7, 2023

Dr. Calabrese is great. Well worth the 500 mile drive!

Reviewed on Mar 2, 2023

Dr. Cassandra Calabrese is consistently outstanding

Reviewed on Feb 15, 2023

Great doctor!

Reviewed on Feb 7, 2023

Dr. Cassandra Calabrese is always kind, compassionate, and interested in knowing how she can help me.

Reviewed on Jan 24, 2023

Dr. C Calabrese was amazing! Great bedside manner, concerned, comforting, definitive, respectful, kind, courteous, very smart and really good at what she does! She was a pleasure to be around and I am thankful I had the opportunity to be seen by her.

Reviewed on Jan 10, 2023

I am completely satisfied with Dr calabrese's patient care. She's engaging, kind, listens and for me I feel she's very caring.

Reviewed on Dec 23, 2022

This televisit was very welcomed! Dr Calabrese's office called the day before asking if we'd mind doing a televisit due to the bad snow storm scheduled to hit us the next day. Couldn't thank them enough for thinking of us! We live an hour and a half away!

Reviewed on Dec 7, 2022

I have had several visits with Dr Calabrese and all have been very good.

Reviewed on Dec 7, 2022

Dr Calabrese is always helpful and concerned

Reviewed on Oct 14, 2022

Amazing experience. Originally I was not able to get an appointment until March. Dr. Calabrese responded to my communication on my chart very promptly and provided advice. I was fortunate enough to be put on a cancellation list and my appointment was moved up to October 15. Dr. Calabrese viewed the requested documentation ahead of my appointment. She took her time with me and was thorough as always. I have a rare condition and she has been a very important part of my medical care team.

Reviewed on Oct 14, 2022

Dr. Calabrese is one of the top specialists taking care of me. At every visit it's clear she's up to date on all my latest tests, wherever taken, and alerts me to potential problems. She is clearly intelligent, but also caring and kind. In short, she's a wonderful physician.

Reviewed on Oct 12, 2022

I am not very techy so using zoom is not easy for me to figure out even with the detailed instructions. Dr. Calebrese always made it easy to connect with me in spite of my limitations connecting with zoom.

Reviewed on Oct 12, 2022

I appreciate and respect Dr. Calabrese so much. I trust her. She listens. I believe she cares for me and my well-being.

Reviewed on Oct 12, 2022

Again, my video care was limited; often it was on the phone because I could not get my video and such working. Dr. Calabrese was terrific in caring for me, helping me and not getting stuck in the logistics of video -- she focused on me. What I wanted her to do, quite frankly.

Reviewed on Oct 12, 2022

Dr Calebrese Is an extremely knowledgeable doctor, but her bedside manner and caring as a human being is absolutely unsurpassed. She's absolutely one of the finest doctors I've ever seen in my 61 years

Reviewed on Sep 23, 2022

Dr. Calabrese is always very thorough.

Reviewed on Aug 30, 2022

Dr. Calabrese was the BEST DOCTOR I've seen at the clinic!! I would HIGHLY RECOMMEND her!!

Reviewed on Aug 30, 2022

Dr Calabrese is wonderful and does her very best to help me with the very difficult issues that I have.

Reviewed on Aug 16, 2022

Dr. Calabrese was amazing. There are no words to describe her compassion and genuine concern to help me. I am forever grateful.

Reviewed on Aug 5, 2022

Doctor C Calabrese is an asset to the CC. She has gone above and beyond for me. I am from NY and she is more than accommodating , not to mention an amazing doctor. I am doing so much better in her care.

Reviewed on Aug 4, 2022

Dr. Calabrese, as always, very kind and mindful about our time. I had a chance to ask her questions and so did she following up on my health. The process of getting the appointment was very smooth.

Reviewed on Jun 24, 2022

I have been very happy with Dr Calabrese and her staff.

Reviewed on Jun 10, 2022

Dr. Calabrese has her staff follow upImmediately after a visit to schedule a follow up appointment

Reviewed on Jun 10, 2022

Dr. Calabrese is a caring, committed physician who clearly cares about her patients, is a great communicator and offers wonderful suggestions for my ongoing care. Her follow up and responsiveness to MyChart messaged is timely and much appreciated.I have a Top 5 list of my many specialists for my complex medical conditions and diagnoses and Dr. Calabrese is on that list. I am blessed to be under her care.

Reviewed on Jun 10, 2022

This was my first initial assessment; Dr. Calabrese is first doctor to ever really listen and show compassion toward my symptoms. She did not skip a beat, very thorough, professional and made me feel at ease after the appointment. I am so happy to have been recommended to her and thankful that there are providers at Cleveland Clinic that genuinely care about their patients.

Reviewed on Jun 8, 2022

Dr. Calabrese provides exceptional care.

Reviewed on May 24, 2022

The Dr is kind and understanding. She takes time to make sure she is understood and that the care plan is inclusive of my needs and her recommendations.

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