Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Bone Density Testing
  • Hyaluronic acid injections
  • Immunology of Infectious Diseases
  • Immunotherapy
  • Infusion Therapy
  • Infusions Of Biologic Agents On Site
  • Joint Aspiration
  • Joint Injections
  • Medication Management
  • Rheumatology
  • Viscosupplementation
View all 11 Treatment & Services +

Specialty in Diseases & Conditions

  • Adult Rheumatology
  • AIDS & HIV
  • Ankylosing Spondylitis
  • Bursitis
  • Connective Tissue Disorders
  • Gout
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Myositis
  • Osteoarthritis
  • Osteopenia
  • Raynaud's Phenomenon
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren's Syndrome
View all 17 Specialties +


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About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Rheumatology
  • Infectious Diseases

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 5/8/2020, Dr. Calabrese has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

157 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
5 out of 5
Explains 4.9
Courtesy, Respect & Concern 5
Patient Rating of Doctor 4.9

43 Patient Comments

Reviewed on Jun 17, 2020

Dr Calabrese always makes herself readily available via My Chart. As a nurse who has worked in healthcare for over 40 years, I never seen nor had such excellent direct access to a physician.

Reviewed on Jun 17, 2020

Dr Calabrese has the ability to listen to a multitude of complex issues and prioritize a treatment plan that is easy to understand and follow. Her ability to listen while interviewing is a remarkable skill set.

Reviewed on Jun 17, 2020

Dr C was very caring and compassionate. she really took her time to make sure all of my questions were answered and I did not feel rushed at all.

Reviewed on Jun 10, 2020

Dr. Cassandra Calabrese shows the upmost respect and compassion for the patient. She intently listens to all of the patient's concerns and definitely includes the patients in any decisions. She thoroughly explains all options and is always available to answer any questions. She is extremely prompt in SS responding to any communications sent to her. Dr. Calabrese is truly someone I respect for all of her expertise that she continually shares. She is a very knowledgeable and kind doctor!

Reviewed on Jun 10, 2020


Reviewed on Jun 9, 2020

dr. calabrese, and her team are a class act! by far my greatest asset for dealing with my disease.

Reviewed on May 22, 2020

Dr Calabrese is AWESOME!!

Reviewed on May 19, 2020

Dr. Calabrese is the only doctor Ive ever had that actually treats me like a person and listens and is empathetic to me being in pain. She has been nothing short of amazing.

Reviewed on May 19, 2020

For visits where Dr. Calabrese and I just talk about treatment and how I have been feeling lately the video calls are perfect. It made my life easier of just being able to talk to her without the travel time. Especially because I had a few questions for her but nothing was needed for me to be at the clinic in person.

Reviewed on May 6, 2020

Dr Calabrese, listens, makes sure I understand everything, takes time, she is very caring.

Reviewed on Mar 27, 2020

It was nice to be able to have a visit and see the doctor without having to drive an hour or be exposed to germs. The technology worked great and I felt like I was there with my doctor.

Reviewed on Mar 25, 2020

Dr C Calabrese , as always was very professional and answered all my questions. Always takes as much time as we need for all my appointments. Never feel rushed with her.

Reviewed on Mar 20, 2020

Dr. Calabrese is one of the most calming doctor's I have ever had. She takes her time and explains things thoroughly. I have great trust in her.

Reviewed on Mar 13, 2020

Love Dr. Calabrese. Due to a language barrier, I often times have my daughter speak on my behalf and Dr. Calabrese has been an excellent communicator with her.

Reviewed on Mar 4, 2020

Dr. C. Calabrese is such a wonderful doctor! She has terrific bedside manner listening intently to her patient questions or specific situation, showing a genuine concern for the patient's needs, and using the expertise and knowledge she has to make the best decision for the patient!

Reviewed on Jan 31, 2020

At the end of the appt dr Calabrese always ask ksasif thereis anything else shecoulddo or answer for us. This is so wonderful because I've had strokes andi it takes me time to process each question and I don't feel rushed.

Reviewed on Jan 31, 2020

my first appointment with dr calabrese I was stressed and in physical pain and started to cry. she was very consoling without being patronizing. I've seen many specialist over 28 years of r dealing with rare autoimmune diseases. dr Calabrese treats you with human kindness which means everything to patients struggling to cope. more should follow her examples of kindness

Reviewed on Jan 3, 2020

Dr. Calabrese is the best doctor I have ever had. I have had many doctors.

Reviewed on Dec 31, 2019

Dr. Calabrese and Cleveland did a wonderful job!

Reviewed on Dec 11, 2019

a caring person and physician

Reviewed on Dec 3, 2019

Dr. Calabrese had very good bedside manners with me and took her time to explain all my symptoms. She has also kept in touch with my daughter due to a lack of English on my end.

Reviewed on Nov 27, 2019

Dr. Calabrese provides exemplary care! The reasons why I believe this is because she is caring go, attentive to all of the patient's needs, and is prompt in answering patient's concerns and questions!

Reviewed on Nov 27, 2019

Dr. Calabrese's is definitely a doctor that truly cares about how the patient feels and will be an advocate for the patient!

Reviewed on Nov 15, 2019

My experience with doctor Calabrese has been amazing. She is very knowledgeable and is truly concerned for her patients. She always answers me back promptly when I reach out to her on the Portal. Living in NY it's great that she responds right away.....

Reviewed on Nov 14, 2019

Dr Calabrese was very caring and made sure I understood everything she was explaining about my condition and treatment plan. she listened to me.

Reviewed on Nov 1, 2019

I think very highly of Dr Cassie Calabrese...

Reviewed on Oct 22, 2019

It is easy to message Dr. Calabrese, and I always get a quick response.

Reviewed on Oct 16, 2019

I was extremely early and the doctor or squeezed me in.

Reviewed on Oct 16, 2019

Very happy with Dr Calabrese

Reviewed on Sep 27, 2019

Dr. Calabrese has been very responsive to my PMR related healthcare needs. She is thorough and patient during office visits. Responsive to questions, and very pleasant. I've sent her several post-visit follow-up questions via My Chart, and she has consistently answered them very promptly. I've been extremely pleased with all aspects of my care at the Arthritis Center with Dr. Calabrese.

Reviewed on Sep 13, 2019

The experience I had with DO Calabrese was great. I had my 2 daughters with me at the time. She took the time to fill them in on my case so they knew what was going on. I truly think she has my best interest at heart. she took a minute to say hello as we walked back to the room. My daughters thought she was very sincere about my condition & treatment. I wish other dr.s showed the same amount of care that was giving to me on this day. I give her 5 stars. 5 being the highest.

Reviewed on Sep 13, 2019

Dr Cassandra Calabrese is a wonderful doctor, always makes me feel comfortable, listens and explains options well. She's very thorough. I just love her. Can not say enough good things about her. She is wonderful, caring, thorough, compassionate. . .she's GREAT!

Reviewed on Aug 16, 2019

dr Calabrese is the most caring, understanding doctor I've ever had. she has gone above and beyond for me and made sure I knew she was doing her job and that she believed me about my health. she spent the necessary time without rushing me and made sure to schedule the next appt so that I didn't have to deal with not being able to get one. I've never met a better doctor

Reviewed on Aug 9, 2019

Dr Calabrese is Great and very concerned

Reviewed on Aug 2, 2019

I have seen many md's over the period of my life, most were very good to excellent. Dr. Calebrese is the best physician I have ever dealt with. She gave me time to give my history, responded to my concerns, and I felt worked with me to find treatment that both would be effective for me and within my comfort range. I left the office having no topic that I would like to have had more opportunity to go over. I found her to be both very professional and very compassionate.

Reviewed on Aug 2, 2019

This is the 13th doctor I've seen. and the only one that has asked me questions, listened, and been empathetic. and incredible experience start to finish.

Reviewed on Aug 1, 2019

Dr Calabrese takes time to listen to me, answers all my questions, explaining and making sure I understand, what and why regarding my treatment and/or any new testing. She is very professional and stays in contact to give me any additional information when test results come in and has helped to refer me to another specialist I need. I always recommend her to anyone I know needing a doctor in her field.

Reviewed on Jul 26, 2019

Dr. Calabrese is a very caring doctor.

Reviewed on Jul 23, 2019

Dr. Calabrese is is the best. She's totally in tune with your concerns and follows through on every level. She's so personable that you truly feel like you're having a sincere one on one with no fail from one appointment to the next. I'd rate her with a hundred stars!

Reviewed on Jul 12, 2019

I have had a very good response with Dr Calabrese, she is very thorough and listens attentively to the problems that you are facing with your arthritis. I like her very much.

Reviewed on Jul 3, 2019

Dr. Calabrese is my Dr. at the clinic. she is very easy to talk to and takes her time explains treatment options. I've always heard back from her when messaging questions and concerns. I would highly recommend her.

Reviewed on Jul 2, 2019

Dr.Cassandra Calabrese is wonderful! Compassionate, takes her time explaining medical issues and has been very beneficial in my treatment

Reviewed on Jun 19, 2019

I am completely impressed with Dr Calabrese's knowledge and beside manner. She validated my symptoms, which helps my anxiety.

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