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Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Administration Of Injectable Medications For Osteoporosis
  • Arthritic Knee Conditions
  • Bone Density Testing
  • Clinical Trials
  • Cortisone injections
  • Diagnosis of Osteoporosis
  • Dual Energy X-ray Absorptiometry (DXA)
  • General Rheumatology
  • General Rheumatology including Lupus
  • Immunoglobulin Infusion
  • Immunology of Infectious Diseases
  • Immunotherapy
  • Infusion Therapy
  • Infusions Of Biologic Agents On Site
  • Joint Aspiration
  • Joint Injections
  • Joint Preservation Center
  • Medical Management of Early Osteoarthritis
  • Medication Management
  • Musculoskeletal Evaluation
  • Musculoskeletal Medicine
  • Musculoskeletal Treatment For Joint Pain
  • Rheumatology
  • Viscosupplementation
View all 24 Treatment & Services +

Specialty in Diseases & Conditions

  • Adult Rheumatology
  • AIDS & HIV
  • Ankylosing Spondylitis
  • Antiphospholipid Syndrome
  • Arthritic Knee Problems
  • Arthritis
  • Arthritis Of The Hip
  • Arthritis Of The Knee
  • Arthritis of the Thumb Base
  • Arthritis of the Wrist & Hand
  • Autoimmune Disease
  • Autoinflammatory Syndromes
  • Behcet's Disease
  • Benign Hypermobility Joint Syndrome
  • Buerger's Disease
  • Bursitis
  • Calcification Tendinitis
  • Calcinosis
  • Central Nervous System Vasculitis
  • Chondrocalcinosis (Pseudo Gout)
  • Churg-Strauss Syndrome
  • Connective Tissue Diseases
  • Connective Tissue Disorders
  • Cryoglobulinemia
  • Dermatomyositis
  • Elbow Arthritis
  • Familial Mediterranean Fever
  • Familial Mediterranean Fever (FMF) Syndrome
  • Giant Cell Arteritis
  • Gout
  • Gout Arthritis
  • Granulomatosis with Polyangitis (Wegener’s)
  • Hand and Wrist Arthritis
  • Hand Pain
  • Hand Problems
  • Henoch Schonlein Purpura
  • Hip Arthritis
  • Hip Disorders
  • Hip Pain
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Iritis
  • Joint Pain
  • Knee Arthritis
  • Knee Joint Disorders
  • Knee Pain
  • Lupus
  • Lupus Anticoagulant
  • Lupus Nephritis
  • Metabolic Bone Disease
  • Metabolic Diseases
  • Microscopic Polyangiitis (MPA)
  • Musculoskeletal Disorders
  • Musculoskeletal Impairments
  • Musculoskeletal Pain
  • Myositis
  • Osteoarthritis
  • Osteopenia
  • Raynaud's Phenomenon
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren's Syndrome
View all 64 Specialties +


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About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Internal Medicine - Rheumatology
  • Internal Medicine - Infectious Disease

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 4/25/2022, Dr. Calabrese has reported the financial relationships with the companies listed below. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Consulting and/or Speaking. Dr. Calabrese receives fees of $5,000 or more per year as a paid consultant, speaker or member of an advisory committee for the following companies:

  • Sanofi Genzyme

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

114 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
4.9 out of 5
Explains 4.9
Courtesy, Respect & Concern 4.9
Patient Rating of Doctor 4.9

30 Patient Comments

Reviewed on Aug 30, 2022

Dr. Calabrese was the BEST DOCTOR I've seen at the clinic!! I would HIGHLY RECOMMEND her!!

Reviewed on Aug 30, 2022

Dr Calabrese is wonderful and does her very best to help me with the very difficult issues that I have.

Reviewed on Aug 16, 2022

Dr. Calabrese was amazing. There are no words to describe her compassion and genuine concern to help me. I am forever grateful.

Reviewed on Aug 5, 2022

Doctor C Calabrese is an asset to the CC. She has gone above and beyond for me. I am from NY and she is more than accommodating , not to mention an amazing doctor. I am doing so much better in her care.

Reviewed on Aug 4, 2022

Dr. Calabrese, as always, very kind and mindful about our time. I had a chance to ask her questions and so did she following up on my health. The process of getting the appointment was very smooth.

Reviewed on Jun 24, 2022

I have been very happy with Dr Calabrese and her staff.

Reviewed on Jun 10, 2022

Dr. Calabrese has her staff follow upImmediately after a visit to schedule a follow up appointment

Reviewed on Jun 10, 2022

Dr. Calabrese is a caring, committed physician who clearly cares about her patients, is a great communicator and offers wonderful suggestions for my ongoing care. Her follow up and responsiveness to MyChart messaged is timely and much appreciated.I have a Top 5 list of my many specialists for my complex medical conditions and diagnoses and Dr. Calabrese is on that list. I am blessed to be under her care.

Reviewed on Jun 10, 2022

This was my first initial assessment; Dr. Calabrese is first doctor to ever really listen and show compassion toward my symptoms. She did not skip a beat, very thorough, professional and made me feel at ease after the appointment. I am so happy to have been recommended to her and thankful that there are providers at Cleveland Clinic that genuinely care about their patients.

Reviewed on Jun 8, 2022

Dr. Calabrese provides exceptional care.

Reviewed on May 24, 2022

The Dr is kind and understanding. She takes time to make sure she is understood and that the care plan is inclusive of my needs and her recommendations.

Reviewed on Apr 29, 2022

Dr Calabrese is everything a patient could want when seeing a provider. I have had great experience with Dr Linda Mileti and Dr Calabrese in Rheumatology

Reviewed on Apr 15, 2022

Dr. Calabrese has always gone above and beyond to accommodate my appointments. When I have had computer problems and unable to zoom, she was understanding and we changed the appointment to a face time.

Reviewed on Apr 14, 2022

Dr. Calabrese is the first doctor that has really listened and tried to help. She seems invested in my journey and keeps up to date with things going on in my life/health.

Reviewed on Mar 25, 2022

Doctor Calabrese is the ultimate professional. She has made my RA tolerable and is always , always putting me first. She's the best!!!

Reviewed on Mar 10, 2022

We are thankful for Dr.Calabrese's care!

Reviewed on Feb 24, 2022

Dr. Calabrese is a physician who makes you feel that your care and your health are extremely important to you. Her genuine kind caring is unparalleled in my experience. She wants a patient to feel valued, understood and heard. Her "bedside manner" is extraordinary.

Reviewed on Feb 2, 2022

Great Doc! I'm complicated and Dr Calabrese takes me on with curiosity and intent to get to the root cause. Really like her.

Reviewed on Feb 1, 2022

Dr. Calabrese is very thorough and knowledgeable. She is easy to talk with and I would highly recommend her!

Reviewed on Jan 27, 2022

Dr listened to me, answered my questions, made sure I understood everything she was going over with me, my care and my prescription

Reviewed on Jan 20, 2022

Dr Calabrese is very good and tries hard to help me

Reviewed on Jan 20, 2022

Dr calabrese listens and has concern for my condition and discusses my condition and treatment

Reviewed on Jan 18, 2022

I recommend Dr Calabrese to a neighbor, and they totally liked her, getting an appt. Etc! Very pleased as I am!

Reviewed on Jan 4, 2022

Dr. Calabrese is extremely prompt at answering any questions or concerns.

Reviewed on Jan 4, 2022

Dr. Calabrese is always extremely thorough.

Reviewed on Jan 4, 2022

Dr. C Calabrese was great. She was patient, kind and very thorough during my visit.

Reviewed on Oct 20, 2021

Dr Calabrese is great! She is always professional, yet friendly and always makes you feel comfortable when discussing your health.

Reviewed on Oct 13, 2021

Dr. Calabrese was wonderful. She was able to work me into her schedule and around my very complicated schedule.

Reviewed on Oct 13, 2021

Dr. Calabrese and the staff were extremely helpful and professional.

Reviewed on Oct 8, 2021

Dr Calabrese was excellent

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