Department Rheumatologic and Immunologic Disease
Primary Location Cleveland Clinic Main Campus
Type of Doctor Adults Only
Languages English
Surgeon No
Locations Specialties & Treatments

Treatment & Services

  • Bone Density Testing
  • Hyaluronic acid injections
  • Immunology of Infectious Diseases
  • Immunotherapy
  • Infusion Therapy
  • Infusions Of Biologic Agents On Site
  • Joint Aspiration
  • Joint Injections
  • Medication Management
  • Rheumatology
  • Viscosupplementation
View all 11 Treatment & Services +

Specialty in Diseases & Conditions

  • Adult Rheumatology
  • AIDS & HIV
  • Ankylosing Spondylitis
  • Bursitis
  • Connective Tissue Disorders
  • Gout
  • Immunodeficiency
  • Immunosuppression
  • Inflammatory Arthritis
  • Myositis
  • Osteoarthritis
  • Osteopenia
  • Raynaud's Phenomenon
  • Retroperitoneal Fibrosis
  • Rheumatoid Arthritis
  • Scleroderma
  • Sjogren's Syndrome
View all 17 Specialties +


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About Cassandra Calabrese, DO

Cassandra Calabrese completed a combined fellowship in rheumatology and infectious diseases, and holds joint appointments in the rheumatology department and the infectious disease department at the Cleveland Clinic. She specializes in infections in the setting of immunosuppressive treatment for rheumatic diseases, rheumatic manifestations of infectious diseases and human immunodeficiency virus, and has a particular interest in infection prevention and immunizations.

In addition, she specializes in rheumatic immune related adverse events from cancer immunotherapy, and is part of a multidisciplinary referral clinic with the Taussig Cancer Center at the Cleveland Clinic.

Education & Professional Highlights

Education & Professional Highlights


Education & Fellowships

Fellowship - Cleveland Clinic
Infectious Disease
Cleveland, OH USA

Fellowship - Cleveland Clinic
Cleveland, OH USA

Residency - Cleveland Clinic
Internal Medicine
Cleveland, OH USA

Medical Education - Heritage College of Osteopathic Medicine
Athens, OH USA

Undergraduate - Kenyon College
Gambier, OH USA

Additional Training

  • Rheumatology ABIM board certified
  • Infectious Disease ABIM board certified


  • Internal Medicine
  • Rheumatology
  • Infectious Diseases

Specialty Interests

immune related adverse events from checkpoint inhibitor therapy, infections in the setting of immunosuppression, infection prevention, HIV/AIDS, rheumatoid arthritis

Research & Publications

Research & Publications

See publications for Cassandra Calabrese, DO.

(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)

Industry Relationships

Industry Relationships

Cleveland Clinic physicians and scientists may collaborate with the pharmaceutical or medical device industries to help develop medical breakthroughs or provide medical expertise or education. Cleveland Clinic strives to make scientific advances that will benefit patient care and support outside relationships that promise public benefit. In order for the discoveries of Cleveland Clinic physicians' and scientists' laboratories and investigations to benefit the public, these discoveries must be commercialized in partnership with industry. As experts in their fields, Cleveland Clinic physicians and scientists are often sought after by industry to consult, provide expertise and education.

To assure professional and commercial integrity in such matters, Cleveland Clinic maintains a program that reviews these collaborations and, when appropriate, puts measures in place to minimize bias that may result from ties to industry. Cleveland Clinic publicly discloses the names of companies when (i) its physicians/scientists receive $5,000 or more per year (or, in rare cases, equity or stock options) for speaking and consulting, (ii) its physicians/scientists serve as a fiduciary, (iii) its physicians/scientists receive or have the right to receive royalties or (iv) its physicians/ scientists hold any equity interest for the physician's/scientist's role as inventor, discoverer, developer, founder or consultant.* In publicly disclosing this information, Cleveland Clinic tries to provide information as accurately as possible about its physicians' and scientists' connections with industry.

As of 5/8/2020, Dr. Calabrese has reported no financial relationship with industry that is applicable to this listing. In general, patients should feel free to contact their doctor about any of the relationships and how the relationships are overseen by Cleveland Clinic. To learn more about Cleveland Clinic's policies on collaborations with industry and innovation management, go to our Integrity in Innovation page.

Public Health Service-Reportable Financial Conflicts of Interest. Cleveland Clinic scientists and physicians engage in basic, translational and clinical research activities, working to solve health problems, enhance patient care and improve quality of life for patients. Interactions with industry are essential to bringing the researchers' discoveries to the public, but can present the potential for conflicts of interest related to their research activities. Click here to view a listing of instances where Cleveland Clinic has identified a Public Health Service (PHS)-Reportable Financial Conflict of Interest and has put measures in place to ensure that, to the extent possible, the design, conduct and reporting of the research is free from bias.

* Cleveland Clinic physicians and scientists subscribe to the guidance presented in the PhRMA Code on Interactions with Healthcare Professionals and the AdvaMed Code of Ethics on Interactions with Health Care Professionals. As such, gifts of substantial value are generally prohibited.

Patient Satisfaction Reviews

153 Patient Satisfaction Reviews

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Cleveland Clinic.

Overall Star Ratings
5 out of 5
Explains 4.9
Courtesy, Respect & Concern 5
Patient Rating of Doctor 5

53 Patient Comments

Reviewed on Sep 21, 2020


Reviewed on Sep 21, 2020

Dr. Cassandra Calabrese is the best Doctor in the entire world!! I love her so much! She is very kind and caring and understands what I go through. I wish I could take her with me back to Florida. I still keep my Cleveland Clinic Doctors because they are the best so it's always worth the flight from Orlando to Cleveland.

Reviewed on Sep 21, 2020

Again, Dr. Cassandra Calabrese is the BEST Doctor ever!!!

Reviewed on Sep 18, 2020

Dr. Calabrese is exceptionally responsive and thoughtful nun her interactions.

Reviewed on Sep 11, 2020

Dr Calabrese is very compassionate and caring. Listens and explains everything clearly.

Reviewed on Sep 9, 2020

Dr. Cassandra Calabrese really listened.

Reviewed on Sep 8, 2020

Dr Calabrese was very pleasant and did not rush through the visit. She made me feel comfortable.

Reviewed on Sep 1, 2020

I have always been impressed with my physician's knowledge. She listens, asks questions about my condition, how it is effecting me, and keeps me informed on treatments. She is the best dr. I have ever had.

Reviewed on Sep 1, 2020

I always mention how great the care is at the Clinic. In fact my husband saw a dr. at your Avon Clinic and he was as impressed as I always am with your drs., staff, even your security guards were caring for him!, Thank you

Reviewed on Aug 21, 2020

Dr. Calabrese is the best!!! love her!!!

Reviewed on Aug 14, 2020

Dr Calabrese listens to me and takes time to explain any tests, any questions I have and treatments in my case.

Reviewed on Aug 11, 2020

Dr C has been great since the first appt. she genuinely cares about the patient and their well being. if she dont know the answer she wants to find someone who will..

Reviewed on Aug 4, 2020

Dr Calabrese is an exceptionally caring person who works hard at listening, understanding, and allowing you to take an active part in decisions concerning your treatment. She is the primary reason that I still deal with the Clinic.

Reviewed on Aug 4, 2020

Dr. Calabrese always listens and explains treatment options so they are understandable.

Reviewed on Jul 29, 2020

Dr. Calabrese has always been very thorough and easy to talk to. My questions and concerns are always addressed and answered to the best of her medical expertise.

Reviewed on Jul 24, 2020

wonderful people and doctors

Reviewed on Jul 10, 2020

I am very impressed with Dr. Calabrese and her Fellow.

Reviewed on Jul 10, 2020

Doctor Calabrese as usual spends as much time as needed with me . Answers all my questions and is very informative and includes me in on every decision we make. She's great!!!!!!

Reviewed on Jul 10, 2020

I come in from Buffalo , NY to see Doctor Calabrese . I could not find the care I needed here and she works with me on every aspect from care to my travel concerns . She is very accommodating .

Reviewed on Jul 9, 2020

Such an amazing Doctor, extremely educated, extremely dedicated and I consider my self very fortunate to be under her care.

Reviewed on Jun 24, 2020

confidence in Doctor

Reviewed on Jun 23, 2020

just an extraordinary, kind, competent, and caring physician. makes Cleveland Clinic the superlative place it is!

Reviewed on Jun 17, 2020

Dr Calabrese always makes herself readily available via My Chart. As a nurse who has worked in healthcare for over 40 years, I never seen nor had such excellent direct access to a physician.

Reviewed on Jun 17, 2020

Dr Calabrese has the ability to listen to a multitude of complex issues and prioritize a treatment plan that is easy to understand and follow. Her ability to listen while interviewing is a remarkable skill set.

Reviewed on Jun 17, 2020

Dr C was very caring and compassionate. she really took her time to make sure all of my questions were answered and I did not feel rushed at all.

Reviewed on Jun 16, 2020

Dr. Calabrese was absolutely amazing, after being pushed off by 2 other rheumatologist because my blood work didn't match my symptoms she listed and understood my common variable immune defficancy and infusions gives fals positives and negatives. so she listed to years of symptoms and concerns, came up with a plan to get to the bottom of things, ordered futher testing and even the next day e mailed back and forth about some of my pilimary results, treatment and how we would handle more tests at my next visit. She even chatted with Dr. Fernandez before I got there for my next appointment. You could see how much care she puts into her patients and I am so lucky to have her as my new rheumatologist.

Reviewed on Jun 16, 2020

With my complicated health I have scean many doctors in different systems, the wonderful way Cleveland clinic is and all the physicians I have sceen out patient as well as inpatient is like a different world. the focus on the patient and the complexity of things and the ease to het to the bottom of things has been absolutely amazing. i am so lucky to have some of the best care anywhere I would travel hours and hours to be taken such good care of and so appreciate how my life and the care I have been receiving for the last 2 years. I am extremely lucky it is inly a 2 1/2 trip away. Form the brilliant doctors, caring nurses, aids, scedulers, even the woman that drives the golf cart on the bridge is so welcoming and remembers us every 3 months when we come for appointments. The hotel being so convenient to stay in when I have multiple appointments or tests or early appointments that I can stay in the night before, rest inbetween, or breaking up the driving when I am not feeling well. All of this has been so much better for my health going from several hospital inpatient stays a month to none in the last 6 months is really giving me my life back and I owe it ti Cleveland clinic thank you!!!

Reviewed on Jun 10, 2020


Reviewed on Jun 10, 2020

Dr. Cassandra Calabrese shows the upmost respect and compassion for the patient. She intently listens to all of the patient's concerns and definitely includes the patients in any decisions. She thoroughly explains all options and is always available to answer any questions. She is extremely prompt in SS responding to any communications sent to her. Dr. Calabrese is truly someone I respect for all of her expertise that she continually shares. She is a very knowledgeable and kind doctor!

Reviewed on Jun 9, 2020

dr. calabrese, and her team are a class act! by far my greatest asset for dealing with my disease.

Reviewed on May 22, 2020

Dr Calabrese is AWESOME!!

Reviewed on May 19, 2020

Dr. Calabrese is the only doctor Ive ever had that actually treats me like a person and listens and is empathetic to me being in pain. She has been nothing short of amazing.

Reviewed on May 19, 2020

For visits where Dr. Calabrese and I just talk about treatment and how I have been feeling lately the video calls are perfect. It made my life easier of just being able to talk to her without the travel time. Especially because I had a few questions for her but nothing was needed for me to be at the clinic in person.

Reviewed on May 6, 2020

Dr Calabrese, listens, makes sure I understand everything, takes time, she is very caring.

Reviewed on Mar 27, 2020

It was nice to be able to have a visit and see the doctor without having to drive an hour or be exposed to germs. The technology worked great and I felt like I was there with my doctor.

Reviewed on Mar 25, 2020

Dr C Calabrese , as always was very professional and answered all my questions. Always takes as much time as we need for all my appointments. Never feel rushed with her.

Reviewed on Mar 20, 2020

Dr. Calabrese is one of the most calming doctor's I have ever had. She takes her time and explains things thoroughly. I have great trust in her.

Reviewed on Mar 13, 2020

Love Dr. Calabrese. Due to a language barrier, I often times have my daughter speak on my behalf and Dr. Calabrese has been an excellent communicator with her.

Reviewed on Mar 4, 2020

Dr. C. Calabrese is such a wonderful doctor! She has terrific bedside manner listening intently to her patient questions or specific situation, showing a genuine concern for the patient's needs, and using the expertise and knowledge she has to make the best decision for the patient!

Reviewed on Jan 31, 2020

At the end of the appt dr Calabrese always ask ksasif thereis anything else shecoulddo or answer for us. This is so wonderful because I've had strokes andi it takes me time to process each question and I don't feel rushed.

Reviewed on Jan 31, 2020

my first appointment with dr calabrese I was stressed and in physical pain and started to cry. she was very consoling without being patronizing. I've seen many specialist over 28 years of r dealing with rare autoimmune diseases. dr Calabrese treats you with human kindness which means everything to patients struggling to cope. more should follow her examples of kindness

Reviewed on Jan 3, 2020

Dr. Calabrese is the best doctor I have ever had. I have had many doctors.

Reviewed on Dec 31, 2019

Dr. Calabrese and Cleveland did a wonderful job!

Reviewed on Dec 11, 2019

a caring person and physician

Reviewed on Dec 3, 2019

Dr. Calabrese had very good bedside manners with me and took her time to explain all my symptoms. She has also kept in touch with my daughter due to a lack of English on my end.

Reviewed on Nov 27, 2019

Dr. Calabrese provides exemplary care! The reasons why I believe this is because she is caring go, attentive to all of the patient's needs, and is prompt in answering patient's concerns and questions!

Reviewed on Nov 27, 2019

Dr. Calabrese's is definitely a doctor that truly cares about how the patient feels and will be an advocate for the patient!

Reviewed on Nov 15, 2019

My experience with doctor Calabrese has been amazing. She is very knowledgeable and is truly concerned for her patients. She always answers me back promptly when I reach out to her on the Portal. Living in NY it's great that she responds right away.....

Reviewed on Nov 14, 2019

Dr Calabrese was very caring and made sure I understood everything she was explaining about my condition and treatment plan. she listened to me.

Reviewed on Nov 1, 2019

I think very highly of Dr Cassie Calabrese...

Reviewed on Oct 22, 2019

It is easy to message Dr. Calabrese, and I always get a quick response.

Reviewed on Oct 16, 2019

I was extremely early and the doctor or squeezed me in.

Reviewed on Oct 16, 2019

Very happy with Dr Calabrese

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