alert icon Coronavirus

Now scheduling COVID-19 vaccines for ages 5+, boosters and third doses
Schedule your appointment
COVID-19 vaccine FAQs

Going to a Cleveland Clinic location?
Nonessential surgeries postponed in Ohio through Dec. 17, 2021
New visitation guidelines
Masks required for patients and visitors (even if you're vaccinated)

Dad and Daughter Have Same Brain Surgery 27 Years Apart

Three days after brain surgery, with her face pale and head wrapped in gauze, 3-month-old Charlotte Misko seemed destined for a long, slow recovery.

As mom Bethany and dad, Zeb, watched over her in Cleveland Clinic Children’s pediatric intensive care unit (PICU), Zeb’s mobile device began ringing. A family member was initiating a video call to check on Charlotte’s condition, generating the service’s distinctive and familiar ringtone.

Suddenly, Charlotte popped up, smiled and tried to reach for the device, evidently eager to see who would soon appear on the screen. Says Bethany, “It was really that smile and her movement that were the first signs to us that she was back and going to be her normal baby self again.” Adds Zeb, “That moment brought us so much joy. We knew our baby was going to be OK.”

Charlotte required open cranial surgery to treat her sagittal craniosynostosis.
Charlotte underwent an open cranial surgery to treat a rare condition called saggital craniosynostosis. (Courtesy: Zeb and Bethany Misko)

Charlotte underwent a 9-hour surgical procedure to treat a rare condition called sagittal craniosynostosis. It occurs when a baby’s skull bones fuse too early, causing a severely misshapen head. While some patients can be treated by undergoing a less invasive surgery and helmet therapy, others – like Charlotte – require open cranial surgery. Surgeons remove a large section of the skull, carefully remodel the bones and then delicately place them back into the head to expand the available space and correct the deformity.

Coincidentally, as no definitive genetic markers have yet been found for the condition, Charlotte’s dad, Zeb, underwent the same procedure when he was a baby, more than 27 years ago. He recovered and has experienced no ill effects in the years hence.

“After the diagnosis, it was a sad moment for us that our newborn daughter would have to go through major surgery,” says Zeb. “But knowing I went through it and turned out OK, and that there have been 27 years of medical advancements since then, we felt peace of mind that everything would be OK.”

Charlotte before and after undergoing open cranial surgery.
Charlotte before surgery (left). Charlotte after surgery (right) showing a significant difference in the shape of her head. (Courtesy: Cleveland Clinic)

A surgical team led by neurosurgeon Violette Recinos, MD, and plastic surgeon Bahar Bassiri Gharb, MD, PhD, carefully planned and executed the operation, which Dr. Bassiri describes as “remodeling Charlotte’s head” from an elongated, rugby ball-like shape, to one that will allow her brain and skull to grow naturally.

As the operation began, the team carefully peeled back the anterior and posterior skin, exposing the bones of the skull. They then made an incision in a zigzag shape, so when Charlotte’s hair would grow back it would be more likely to cover the scar.

Charlotte, her mom Bethany, and dad, Zeb.
Bethany, Charlotte and Zeb at church, after Charlotte underwent surgery at Cleveland Clinic. (Courtesy: Zeb and Bethany Misko)

Then, Dr. Bassiri carefully marked the places on the skull where the incisions would be made. Dr. Recinos performed the necessary osteotomies, which involved cutting pieces of bone to remove or reshape them.

At that point, Dr. Bassiri put the pieces of Charlotte’s skull back together, like a jigsaw puzzle. “We were careful to do this in a way that would make the head shape more round,” she explains. “We created a new shape while expanding the skull in order for the brain to grow into it.”

Dr. Bassiri with Charlotte during one of her follow-up appointments.
Dr. Bassiri performing an exam during one of Charlotte's follow-up appointments. (Courtesy: Cleveland Clinic)

After the team completed the process, they sutured the skin back in place. Bethany, a pharmacy practice resident, recalls the shock when she and Zeb first saw Charlotte after surgery.

“The first time we saw her after surgery was probably the scariest,” recalls Bethany. “She looked like a little doll hooked up to every tube and pressure cuff under the sun, with a gauze hat on her head. Her face was so pale and swollen, but we knew she was OK.”

Charlotte has been thriving after undergoing brain surgery for her rare condition.
Charlotte has been doing well after surgery and continues reaching most developmental milestones. (Courtesy: Zeb and Charlotte Misko)

Charlotte has been thriving ever since. Regular checkups reveal she is reaching most developmental milestones. When friends and family gathered for her first birthday on August 10, 2021, Charlotte showed off her newfound ability to (almost) walk!

Dr. Bassiri encourages parents who believe their newborn has a cranial deformity to learn more about it quickly, as procedures to correct the condition are less invasive in the first few weeks and months of life.

Charlotte turned 1-year-old on August 10, 2021.
Charlotte loved digging into her smash cake at her first birthday party. She turned 1-year-old on August 10, 2021. (Courtesy: Zeb and Bethany Misko)

“This is often a diagnosis made by parents first, especially if they have other kids and see the shape of the (baby’s) head does not look normal to them,” she explains. “Insist to see a specialist, because we have all the instruments needed to make (any procedure) safe and to minimize possible complications.”

“Charlotte is doing fantastic. Crawling everywhere at the speed of light,” notes Zeb, who believes his success from surgery nearly three decades earlier gave him confidence that Charlotte’s recovery would be similar. “We’re happy to see so much progress in such a short amount of time.”

Related Institutes: Neurological Institute, Dermatology & Plastic Surgery Institute, Cleveland Clinic Children's
Patient Stories

Patient Stories

Brad crossing the finish line at the Boston Marathon.

Five Months After Aortic Root Aneurysm Surgery, Man Runs the Boston Marathon

Dec 3, 2021

“I hope my story provides some inspiration to others, that you can get back to what you love even after heart surgery. It’s been quite a ride.”
Read Story
Alayna and Nate's mom insisted paramedics take Nate to Cleveland Clinic when he suffered a stroke.

Groom Suffers Stroke At Wedding, Recovers After Surgeons Remove Clots

Nov 30, 2021

“Nothing stands out to me as being a challenge anymore. Physically I don’t have any mobility issues or gait concerns.”
Read Story
Kalil Masri spent 230 days in the hospital from complications related to COVD-19.

Doctor Hospitalized 230 Days From COVID-19 Receives Double-Lung Transplant

Nov 29, 2021

“If a vaccine had been available for me, maybe if I had gotten COVID I would have had milder symptoms and not ended up needing a transplant.”
Read Story
Back to Top