Intravenous Iron Supplementation


What is iron?

Iron is one of the minerals in the human body. It is one of the components of hemoglobin, the substance in red blood cells that helps blood carry oxygen throughout the body.

If you do not have enough iron, your body cannot make hemoglobin, and you may develop anemia. This is known as iron-deficiency anemia, the most common type of anemia.

Factors that can lower your body's supply of iron include:

  • Blood loss (caused by ulcers, some cancers, and other conditions; and, in women, during monthly periods)
  • A diet that doesn't have enough iron in it
  • Taking medications that interfere with the ability of the body to absorb iron
  • An increase in the body's need for iron (for instance, in women during pregnancy)

What are the symptoms of anemia?

There are several symptoms that may occur in all types of anemia. They are:

Who is most likely to develop iron-deficiency anemia?

Anyone can develop iron-deficiency anemia, although the following groups have a higher risk:

  • Women: Blood loss during monthly periods and childbirth can lead to anemia
  • People over 65, who are more likely to have iron-poor diets
  • People who are on blood thinners such as aspirin, Plavix®, Coumadin®, or heparin
  • People who have kidney failure (especially if they are on dialysis), because they have trouble making red blood cells
  • People who have trouble absorbing iron

Who receives intravenous iron supplementation?

Patients who receive IV iron usually do so because they cannot take oral iron. These include the following:

  • Patients who are bleeding in the gastrointestinal (GI) tract (the gut) and need to replace iron quickly. (IV iron is absorbed by the body more rapidly than oral iron.)
  • Patients who have inflammatory bowel disease (diseases of the intestines that cause pain, diarrhea, and weight loss), and cannot take oral iron because it upsets their GI tract.
  • Patients who are on kidney dialysis, who often lose blood during dialysis. In addition, these patients are usually taking an erythropoietin stimulating agent (ESA) and may need extra iron.
  • Patients with iron-deficiency anemia who are having high blood loss surgery (> 500 ml) within the next 2 months and need to replace iron quickly. (IV iron is absorbed by the body more rapidly than oral iron.)
  • Patients with celiac disease (gluten intolerance).
  • Cancer patients who have anemia and are taking an ESA.

Procedure Details

How is anemia diagnosed?

Your healthcare provider can perform blood tests to tell if you have anemia. The type and number of blood tests will depend on what type of anemia your doctor thinks you might have.

The blood tests will measure your hemoglobin and how much iron is in your body. If these levels are low, the doctor can make a diagnosis of anemia.

How is anemia treated?

Your healthcare provider will decide on the proper treatment, depending on the type of anemia and what is causing it.

Your doctor must first find out if the anemia is being caused by a poor diet or a more serious health problem. You can then be treated for both the anemia and its cause.

One way of treating iron-deficiency anemia is by eating foods that are high in iron. The following foods are good sources of iron:

  • Oysters
  • Kidney beans
  • Beef liver
  • Tofu
  • Beef (chuck roast, lean ground beef)
  • Turkey leg
  • Whole wheat bread
  • Tuna
  • Eggs
  • Shrimp
  • Peanut butter
  • Leg of lamb
  • Brown rice
  • Raisin bran (enriched)

Another way to treat anemia is by taking oral (by mouth) iron supplements (pills). The patient may also need to take erythropoietin-stimulating agents (ESAs). ESAs work by helping to make more red blood cells. These cells are then released from the bone marrow into the bloodstream. ESAs are given by injection (shot) or intravenously.

In cases where the patient cannot take oral iron supplements, he or she may have to have intravenous iron supplementation. As with any medication, do not take any supplements without the advice and direction of your physician.

What is intravenous iron supplementation?

Intravenous (IV) iron supplementation is a method of delivering iron by infusion with a needle into a vein. (Medication that is given intravenously is called parenteral therapy.)

How is intravenous iron given?

Intravenous iron is delivered into the patient's vein through a needle. The procedure takes place in a doctor's office or a clinic and may take up to several hours, depending on which treatment the physician has prescribed. The patient usually receives iron injections over the course of several visits until his or her iron levels are correct.

Risks / Benefits

What are the side effects of intravenous iron?

The side effects of IV iron are usually minimal, but may include the following:

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • Gastrointestinal pains, including nausea and cramps
  • Problems with breathing
  • Skin problems, including rash
  • Chest pain
  • Low blood pressure
  • Anaphylaxis (a severe reaction that can include difficulty breathing, itching, or a rash over the entire body)

How effective is intravenous iron?

When you should start to feel better depends on your particular situation. Normally, it may take from a week to a month after you start your iron supplement before you start to feel better. Continue to watch your symptoms and take note of side effects that might be caused by the supplements. If you have any questions or concerns, talk to your healthcare provider.

Last reviewed by a Cleveland Clinic medical professional on 07/17/2019.


  • National Heart, Lung, and Blood Institute. What Is Anemia? ( Accessed 5/7/2018.
  • National Heart, Lung, and Blood Institute. Your Guide to Anemia ( Accessed 5/7/2018.
  • American Society of Hematology. Iron-Deficiency Anemia ( Accessed 5/7/2018.

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