Ripretinib Tablets

What is this medication?

RIPRETINIB (rip RE ti nib) treats a type of gastrointestinal (GI) cancer. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): QINLOCK

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Having surgery
• Heart disease
• High blood pressure
• Skin conditions or sensitivity
• An unusual or allergic reaction to ripretinib, other medications, foods, dyes or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush, or chew this medication. Swallow the tablets whole. You can take this medication with or without food. However, you should always take it the same way. Do not take with grapefruit juice. Take your medication at regular intervals. Do not take it more often than directed. Do not stop taking except on your care team's advice.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can unless it is more than 8 hours late. If it is more than 8 hours late, skip the missed dose. Take the next dose at the normal time.

What may interact with this medication?

• Apalutamide
• Certain antibiotics, such as clarithromycin, chloramphenicol, telithromycin
• Certain antiviral medications for HIV or hepatitis
• Certain medications for cancer treatment, such as ceritinib, idelalisib, ribociclib, sotorasib, tucatinib
• Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole
• Certain medications for seizures, such as carbamazepine, fosphenytoin/phenytoin, phenobarbital, primidone
• Conivaptan
• Enzalutamide
• Grapefruit juice
• Lumacaftor; ivacaftor
• Mifepristone
• Mitotane
• Nefazodone
• Rifampin
• St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

Before having surgery, talk to your care team to make sure it is ok. This medication can increase the risk of poor healing of your surgical site or wound. You will need to stop this medication for 1 week before surgery. After surgery, wait at least 2 weeks before restarting this medication. Make sure the surgical site or wound is healed enough before restarting this medication. Talk to your care team if questions.

This medication can make you more sensitive to the sun. Keep out of the sun while taking this medication and for at least 1 week after stopping it. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps or tanning beds/booths.

Talk to your care team if you wish to become pregnant or think you may be pregnant. This medication can cause serious birth defects if taken during pregnancy and for 1 week after stopping it. A negative pregnancy test is required before starting this medication. A reliable form of contraception while taking this medication and for 1 week after stopping it is recommended. If you become pregnant, miss a menstrual cycle, or stop using contraception, call your care team.

Males who get this medication must use a reliable form of contraception during sex with females who can get pregnant. If you get a woman pregnant, there is potential for serious harm to an unborn child. You will need to continue using contraception for 1 week after stopping this medication. Tell your care team right away if you think your partner may be pregnant.

Do not breast-feed while taking this medication or for 1 week after stopping it.

This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
• Increase in blood pressure
• Redness, swelling, and blistering of the skin over hands and feet

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Hair loss
• Muscle pain
• Nausea
• Sensitivity to light
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 15 and 30 degrees C (59 and 86 degrees F). Keep this medication in the original container. Do not throw out the packet in the container. It keeps the medicine dry.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.