Tixagevimab; Cilgavimab Solutions for Injection

What is this medication?

TIXAGEVIMAB; CILGAVIMAB (tix a jev i mab; sil gav i mab) reduces the risk of getting COVID-19 in persons with immune system problems who may not respond properly to the COVID-19 vaccine or persons who can't receive the COVID-19 vaccine. It belongs to a group of medications called monoclonal antibodies. It may decrease the risk of developing severe symptoms of COVID-19. It may also decrease the chance of going to the hospital. This medication is not approved by the FDA. The FDA has authorized emergency use of this medication during the COVID-19 pandemic.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): EVUSHELD

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• any allergies
• any serious illness
• bleeding disorder
• have received a COVID-19 vaccine
• heart disease
• an unusual or allergic reaction to tixagevimab, cilgavimab, other medications, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medication is injected into a muscle. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. While it may be given to children as young as 12 years, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

• COVID-19 vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication. Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

After receiving this medication, wait at least 14 days before getting the COVID-19 vaccine.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
• Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Cough
• Fatigue
• Headache
• Pain, redness, or irritation at site where injected

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.