Loncastuximab Tesirine Injection

What is this medication?

LONCASTUXIMAB TESIRINE (lon kas tux i mab tes ir een) is a chemotherapy medicine and monoclonal antibody. It treats certain types of lymphoma.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): ZYNLONTA

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• infection
• liver disease
• an unusual or allergic reaction to loncastuximab tesirine, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is infused into a vein. It is given by a health care provider in a hospital or clinic setting.

Talk to your health care provider about the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your health care provider if you are unable to keep an appointment.

What may interact with this medication?

Interactions have not been studied.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

You may need bloodwork while taking this medication.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use lamps or tanning beds/booths.

Do not become pregnant while taking this medication or for 10 months after stopping it. Talk to your care team if you or your partner wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child.

Do not breast-feed while taking this medication or for 3 months after stopping it. Tell your care team right away if you think your partner might be pregnant.

This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions (skin rash; itching or hives; swelling of the face, lips, or tongue)
• chest pain
• edema (sudden weight gain; swelling of the ankles, feet, hands or other unusual swelling; trouble breathing)
• high blood sugar (increased hunger, thirst, or urination; blurry vision)
• infection (fever, chills, cough, sore throat, pain or trouble passing urine)
• low red blood cell counts (feeling faint; lightheaded, falls; unusually weak or tired)
• mild skin irritation, redness, or dryness
• unusual bruising or bleeding

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• joint pain
• muscle pain
• nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medicine is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.