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DARATUMUMAB; HYALURONIDASE (dar a toom ue mab; hye al ur ON i dase) treats multiple myeloma, a type of bone marrow cancer. Daratumumab works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells. Hyaluronidase works by increasing the absorption of other medications in the body to help them work better. This medication may also be used treat amyloidosis, a condition that causes the buildup of a protein (amyloid) in your body. It works by reducing the buildup of this protein, which decreases symptoms. It is a combination medication that contains a monoclonal antibody.
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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): DARZALEX FASPRO
They need to know if you have any of these conditions:
This medication is injected under the skin. It is given by your care team in a hospital or clinic setting.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.
Interactions have not been studied.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
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Your condition will be monitored carefully while you are receiving this medication.
This medication can cause serious allergic reactions. To reduce your risk, your care team may give you other medication to take before receiving this one. Be sure to follow the directions from your care team.
This medication can affect the results of blood tests to match your blood type. These changes can last for up to 6 months after the final dose. Your care team will do blood tests to match your blood type before you start treatment. Tell all of your care team that you are being treated with this medication before receiving a blood transfusion.
This medication can affect the results of some tests used to determine treatment response; extra tests may be needed to evaluate response.
Talk to your care team if you wish to become pregnant or think you are pregnant. This medication can cause serious birth defects if taken during pregnancy and for 3 months after the last dose. A reliable form of contraception is recommended while taking this medication and for 3 months after the last dose. Talk to your care team about effective forms of contraception.
Do not breast-feed while taking this medication.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
This medication is given in a hospital or clinic. It will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.