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Luspatercept Injection

What is this medication?

LUSPATERCEPT (lus PAT er sept) treats low levels of red blood cells (anemia) in the body in people with beta thalassemia or myelodysplastic syndromes. It works by helping the body make more red blood cells.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): REBLOZYL

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Have had your spleen removed
  • High blood pressure
  • History of blood clots
  • Tobacco use
  • An unusual or allergic reaction to luspatercept, other medications, foods, dyes or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for injection under the skin. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of the medication in children. This medication is not approved for use in children.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects. Discuss contraceptive options with your care team. Do not breastfeed while taking this medication.

You may need blood work done while you are taking this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Increase in blood pressure
  • Severe back pain, numbness or weakness of the hands, arms, legs, or feet, loss of coordination, loss of bowel or bladder control

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Bone pain
  • Dizziness
  • Fatigue
  • Headache
  • Joint pain
  • Muscle pain
  • Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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