What is this medicine?
TRASTUZUMAB DERUXTECAN (tras TOOZ eu mab DER ux TEE kan) is a monoclonal antibody combined with chemotherapy. It is used to treat breast cancer.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): ENHERTU
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
- heart disease
- heart failure
- infection (especially a virus infection such as chickenpox, cold sores, or herpes)
- liver disease
- lung or breathing disease, like asthma
- an unusual or allergic reaction to fam-trastuzumab deruxtecan, other medications, foods, dyes, or preservatives
- pregnant or trying to get pregnant
How should I use this medicine?
This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.
What may interact with this medicine?
Interaction studies have not been performed.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your healthcare professional for regular checks on your progress. Tell your healthcare professional if your symptoms do not start to get better or if they get worse.
Your condition will be monitored carefully while you are receiving this medicine.
Do not become pregnant while taking this medicine or for 7 months after stopping it. Women should inform their healthcare professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 4 months after stopping it. There is potential for serious side effects to an unborn child. Talk to your healthcare professional for more information.
Do not breast-feed an infant while taking this medicine or for 7 months after the last dose.
This medicine has caused decreased sperm counts in some men. This may make it more difficult to father a child. Talk to your healthcare professional if you are concerned about your fertility.
This medicine may increase your risk to bruise or bleed. Call your health care professional if you notice any unusual bleeding.
Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
This medicine may cause dry eyes [and blurred vision]. If you wear contact lenses, you may feel some discomfort. Lubricating eye drops may help. See your healthcare professional if the problem does not go away or is severe.
Call your healthcare professional for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This medicine decreases your body's ability to fight infections. Try to avoid being around people who are sick.
Avoid taking medicines that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your healthcare professional. These medicines may hide a fever.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- nausea, vomiting
- signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
- signs and symptoms of heart failure like breathing problems, fast, irregular heartbeat, sudden weight gain; swelling of the ankles, feet, hands; unusually weak or tired
- signs and symptoms of infection like fever; chills; cough; sore throat; pain or trouble passing urine
- signs and symptoms of low red blood cells or anemia such as unusually weak or tired; feeling faint or lightheaded; falls; breathing problems
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
- dry eyes
- hair loss
- loss of appetite
- mouth sores
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy