Methoxsalen Injection

What is this medication?

METHOXSALEN (me THOK suh luhn) treats skin sores caused by lymphoma. It is used in combination with ultraviolet light therapy. It works by slowing down the growth of cancer cells.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): UVADEX

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Aphakia, a condition where there is no eye lens
• Conditions that make your skin sensitive to light, such as albinism, lupus, some types of porphyria
• Heart disease
• Liver disease
• Skin cancer
• An unusual or allergic reaction to methoxsalen, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

How should I use this medication?

This medication is mixed with your collected white blood cells during a procedure. The mixture is injected back into your body. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

Do not take this medication with the following:

• Fezolinetant

This medication may also interact with the following:

• Anthralin
• Certain antibiotics, such as sulfamethoxazole or tetracycline
• Certain bacteriostatic soaps
• Certain medications for seizures, such as phenytoin
• Coal tar
• Diuretics, such as chlorthalidone or hydrochlorothiazide
• Griseofulvin
• Medical dyes, such as methylene blue, toluidine blue, rose bengal, methyl orange
• Nalidixic acid
• Phenothiazines, such as chlorpromazine, prochlorperazine, thioridazine
• Retinoids, such as bexarotene, tazarotene, tretinoin
• Sulfonamides, such as sulfacetamide

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

This medication may cause cataracts. You should have regular eye exams while taking this medication. Tell your care team if you have changes in your eyesight.

Talk to your care team about your risk of skin cancer. You may be more at risk for skin cancer if you take this medication.

This medication can make you more sensitive to the sun. Avoid direct and indirect sunlight for 24 hours after treatment. If you cannot avoid sunlight, wear protective clothing and sunscreen. Do not use sun lamps, tanning beds, or tanning booths.

Wear wrap-around sunglasses that block all UV light when outside or near a window. Avoid sunlight for 24 hours after treatment.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
• Change in vision
• Skin reactions on sun-exposed areas

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.