What is this medicine?

METHYLPREDNISOLONE (meth ill pred NISS oh lone) is a corticosteroid. It is commonly used to treat inflammation of the skin, joints, lungs, and other organs. Common conditions treated include asthma, allergies, and arthritis. It is also used for other conditions, such as blood disorders and diseases of the adrenal glands.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): A-Methapred, Solu-Medrol

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • Cushing's syndrome
  • eye disease, vision problems
  • diabetes
  • glaucoma
  • heart disease
  • high blood pressure
  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)
  • liver disease
  • mental illness
  • myasthenia gravis
  • osteoporosis
  • recently received or scheduled to receive a vaccine
  • seizures
  • stomach or intestine problems
  • thyroid disease
  • an unusual or allergic reaction to lactose, methylprednisolone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection or infusion into a vein. It is also for injection into a muscle. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • alefacept
  • echinacea
  • iopamidol
  • live virus vaccines
  • metyrapone
  • mifepristone

This medicine may also interact with the following medications:

  • amphotericin B
  • aspirin and aspirin-like medicines
  • certain antibiotics like erythromycin, clarithromycin, troleandomycin
  • certain medicines for diabetes
  • certain medicines for fungal infection like ketoconazole
  • certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
  • certain medicines that treat or prevent blood clots like warfarin
  • cyclosporine
  • digoxin
  • diuretics
  • female hormones, like estrogens and birth control pills
  • isoniazid
  • NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
  • other medicines for myasthenia gravis
  • rifampin
  • vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Do not stop taking except on your doctor's advice. You may develop a severe reaction. Your doctor will tell you how much medicine to take.

Your condition will be monitored carefully while you are receiving this medicine.

This medicine may increase your risk of getting an infection. Tell your doctor or health care professional if you are around anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes.

Tell your doctor or health care professional right away if you have any change in your eyesight.

Using this medicine for a long time may increase your risk of low bone mass. Talk to your doctor about bone health.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bloody or tarry stools
  • hallucination, loss of contact with reality
  • muscle cramps
  • muscle pain
  • palpitations
  • signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.
  • signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine
  • trouble passing urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in emotions or mood
  • constipation
  • diarrhea
  • excessive hair growth on the face or body
  • headache
  • nausea, vomiting
  • pain, redness, or irritation at site where injected
  • trouble sleeping
  • weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2021 Elsevier Inc. All Rights Reserved. Terms of Use.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy