Sodium Hyaluronate intra-articular injection

What is this medication?

SODIUM HYALURONATE (SOE dee um hye al yoor ON ate) is used to treat pain in the knee due to osteoarthritis.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Amvisc, DUROLANE, Euflexxa, GELSYN-3, Hyalgan, Hymovis, Monovisc, Orthovisc, Supartz, Supartz FX, TriVisc, VISCO


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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • bleeding disorders
  • glaucoma
  • infection in the knee joint
  • skin conditions or sensitivity
  • skin infection
  • an unusual allergic reaction to sodium hyaluronate, other medicines, foods, dyes, or preservatives. Different brands of sodium hyaluronate contain different allergens. Some may contain egg. Talk to your doctor about your allergies to make sure that you get the right product.
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

This medicine is for injection into the knee joint. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.


What if I miss a dose?

This does not apply.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


What should I watch for while using this medication?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

If receiving this medicine for osteoarthritis, limit your activity after you receive your injection. Avoid physical activity for 48 hours following your injection to keep your knee from swelling. Do not stand on your feet for more than 1 hour at a time during the first 48 hours following your injection. Ask your doctor or healthcare professional about when you can begin major physical activity again.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • dizziness
  • facial flushing
  • pain, tingling, numbness in the hands or feet
  • vision changes if received this medicine during eye surgery

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • back pain
  • bruising at site where injected
  • chills
  • diarrhea
  • fever
  • headache
  • joint pain
  • joint stiffness
  • joint swelling
  • muscle cramps
  • muscle pain
  • nausea, vomiting
  • pain, redness, or irritation at site where injected
  • weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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