Locations:

Betamethasone topical spray

What is this medication?

BETAMETHASONE (bay ta METH a sone) is a corticosteroid. It is used on the skin to treat itching, redness, and swelling caused by some skin conditions.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Sernivo

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • acne or rosacea
  • any type of active infection
  • diabetes
  • eye disease, vision problems
  • glaucoma or cataracts
  • large areas of burned or damaged skin
  • skin wasting or thinning
  • an unusual or allergic reaction to betamethasone, corticosteroids, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

This medicine is for external use only. Do not take by mouth. Follow the directions on the prescription label. Shake well before using. Wash your hands before and after use. Apply to clean dry skin. Use only enough to cover the affected areas. Do not use on healthy skin or over large areas of skin. Rub in gently but completely. Do not cover with a bandage or dressing unless your doctor or health care professional tells you to. Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water. Do not use your medicine more often than directed or for longer than ordered by your doctor or health care professional. To do so may increase the chance of side effects.

Advertisement

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Elderly patients are more likely to have damaged skin through aging, and this may increase side effects. This medicine should only be used for brief periods and infrequently in older patients.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

Interactions are not expected. Do not use any other skin products without telling your doctor or health care professional.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your doctor or health care professional if your symptoms do not get better within 4 weeks, or if you develop skin irritation from the medicine.

Tell your doctor or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • burning or itching of the skin that does not go away
  • dark red spots on the skin
  • infection
  • lack of healing of skin condition
  • painful, red, pus filled blisters in hair follicles
  • thinning of the skin, with easy bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dry skin
  • increased redness or scaling of the skin
  • mild burning, itching, or irritation of the skin

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Once the spray is in use, throw away any unused medicine after 28 days or the expiration date on the label, whichever comes first.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Advertisement

Advertisement

Copyright ©2025 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

Ad
Call Appointment Center 866.320.4573
Questions 216.444.2200