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Rivaroxaban Tablets

Xarelto® is a blood thinner that treats or prevents blood clots. You may need it if you had a blood clot in your leg or lung. Or you may need it because you have atrial fibrillation but no heart valve issues. Xarelto also prevents clots after surgery to replace your knee or hip. Xarelto keeps factor Xa from helping make clots.

What is this medication?

RIVAROXABAN (ri va ROX a ban) prevents or treats blood clots. It is also used to lower the risk of stroke in people with AFib (atrial fibrillation). It can be used to lower the risk of heart attack or stroke in people with heart or peripheral artery disease. It belongs to a group of medications called blood thinners.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Xarelto, Xarelto Starter Pack

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Antiphospholipid syndrome (APS)
  • Bleeding problems
  • Having surgery, an epidural, a spinal tap, or any other procedure that involves the area around your spine
  • Kidney disease
  • Liver disease
  • Prosthetic heart valve
  • An unusual or allergic reaction to rivaroxaban, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

Take this medication by mouth. For your therapy to work as well as possible, take each dose exactly as prescribed on the prescription label. Do not skip doses. Skipping doses or stopping this medication can increase your risk of a blood clot or stroke. Keep taking this medication unless your care team tells you to stop.

If you are taking this medication after hip or knee replacement surgery, take it with or without food. If you are taking this medication for atrial fibrillation, take it with your evening meal. If you are taking this medication to treat blood clots, take it with food at the same time each day. If you are taking this medication for coronary artery disease or peripheral artery disease, take it with or without food at the same time every day. If you are unable to swallow your tablet, you may crush the tablet and mix it in applesauce. Then, immediately eat the applesauce. You should eat more food right after you eat the applesauce containing the crushed tablet.

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A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as newborns for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you take your medication once a day and miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

If you are taking this medication twice a day to treat blood clots and miss a dose, take the missed dose as soon as you remember. In this instance, 2 tablets may be taken at the same time. The next day you should take 1 tablet twice a day.

If you are taking this medication twice a day for coronary artery disease or peripheral artery disease and miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

What may interact with this medication?

Do not take this medication with any of the following:

  • Defibrotide

This medication may also interact with the following:

  • Aspirin and aspirin-like medications
  • Certain antibiotics, such as erythromycin and clarithromycin
  • Certain medications for fungal infections, such as ketoconazole and itraconazole
  • Certain medications for seizures, such as carbamazepine and phenytoin
  • Certain medications that treat or prevent blood clots, such as warfarin, enoxaparin, dalteparin, apixaban, dabigatran, and edoxaban
  • Conivaptan
  • Indinavir
  • Lopinavir; ritonavir
  • NSAIDS, medications for pain and inflammation, such as ibuprofen or naproxen
  • Rifampin
  • Ritonavir
  • SNRIs, medications for depression, such as desvenlafaxine, duloxetine, levomilnacipran, and venlafaxine
  • SSRIs, medications for depression, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline
  • St. John's wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

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You may need blood work done while you are taking this medication.

Avoid sports and activities that may cause injury while you are taking this medication. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your care team.

Before having surgery, dental work, or another procedure, tell your care team that you are taking this medication.

People who take this medication and have a spinal procedure are at risk of forming a blood clot in the space around the brain or spinal cord. This could cause paralysis (not being able to move). The risk is higher in people who have spinal problems or injuries, have had spinal surgery in the past, and for those with a tube (catheter) in their back. Taking other medications that also affect bleeding, such as NSAIDs or other blood thinners, can also increase the risk. Your care team will watch you closely. Let them know right away if you feel pain, tingling, or numbness in your legs or feet.

Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.

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Talk to your care team if you may be pregnant. Serious fetal side effects, such as bleeding, may occur if you take this medication during pregnancy. There are benefits and risks to taking medications during pregnancy. Your care team can help you find the option that works for you.

Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Bleeding in the brain—severe headache, stiff neck, confusion, dizziness, change in vision, numbness or weakness of the face, arm, or leg, trouble speaking, trouble walking, vomiting
  • Heavy periods

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

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To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2025 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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