Doxylamine; Vitamin B6 Delayed- and Extended-Release Tablets

What is this medication?

DOXYLAMINE; VITAMIN B6 (dox IL a meen; VAHY tuh min B6) treats nausea and vomiting during pregnancy. It works by blocking substances in your body that cause nausea and vomiting. It is a combination of an antihistamine and vitamin B6.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): BONJESTA, Diclegis

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Glaucoma
  • Liver disease
  • Pain or trouble passing urine
  • Prostate disease
  • Stomach ulcers, other stomach or intestine problems
  • An unusual or allergic reaction to doxylamine, pyridoxine (vitamin B6), other medications, foods, dyes, or preservatives
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the tablets whole. Take it on an empty stomach. Do not use it more often than directed. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

  • Alcohol
  • Atropine
  • Antihistamines for allergy, cough and cold
  • Certain medications for bladder problems, such as oxybutynin, tolterodine
  • Certain medications for stomach problems, such as dicyclomine, hyoscyamine
  • Certain medications for travel sickness, such as scopolamine
  • Certain medications for Parkinson's disease, such as benztropine, trihexyphenidyl
  • Ipratropium
  • MAOIs, such as Marplan, Nardil, and Parnate

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse. See your care team right away if you get a high fever or have problems breathing.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

This medication may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your care team if the problem does not go away or is severe.

This medication may cause false positive urine tests for certain medications like methadone, opiates, and PCP.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Confusion
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep bottle tightly closed and protect from moisture. Do not remove desiccant canister from bottle. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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