What is this medicine?

RIFAMPIN (RIF am pin) is an antibiotic. It is used to treat or prevent certain kinds of bacterial infections. It is used to treat or prevent tuberculosis (TB). It will not work for colds, flu, or other viral infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Rifadin, Rimactane

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes
  • HIV or AIDS
  • if you often drink alcohol
  • liver disease
  • poor nutrition
  • wear contact lenses
  • an unusual or allergic reaction to rifampin, rifabutin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, either 1 hour before or 2 hours after food. Take your doses at regular intervals. Do not take your medicine more often than directed. For your therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • delavirdine
  • nevirapine
  • sirolimus
  • voriconazole

This medicine may also interact with the following medications:

  • antibiotics like ciprofloxacin, clarithromycin, isoniazid
  • antifungal medicines like fluconazole, itraconazole, ketoconazole
  • atovaquone
  • chloramphenicol
  • cyclosporine
  • dapsone
  • female hormones, including contraceptive or birth control pills
  • halothane
  • medicines for blood pressure, other heart problems
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for diabetes
  • medicines for pain
  • medicnes for seizures like carbamazepine, phenobarbital, phenytoin
  • medicines for sleep
  • medicines for the thyroid
  • medicines that treat or prevent blood clots like warfarin
  • probenecid
  • steroid medicines like prednisone or cortisone
  • vitamin D

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care provider if your symptoms do not start to get better or if they get worse.

This medicine may cause serious skin reactions. They can happen weeks to months after starting the medicine. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

This medicine can color your teeth, urine, sweat, tears, and mucous. The color may stain your teeth for good. The color in tears may also stain soft contact lenses for good. If you wear contact lenses, ask your doctor or health care provider when you can use your lenses again.

You may need blood work done while you are taking this medicine.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

This medicine may cause a decrease in vitamin D and vitamin B6. You should make sure that you get enough vitamins while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care provider .

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bloody or watery diarrhea
  • breathing problems
  • feeling faint or lightheaded, falls
  • rash, fever, and swollen lymph nodes
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose
  • signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine
  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • confusion
  • diarrhea
  • dizziness
  • drowsiness
  • headache
  • loss of appetite
  • nausea, vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Protect from light and moisture. Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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