Fosamprenavir Tablets

What is this medication?

FOSAMPRENAVIR (FOS am pren a veer) helps manage the symptoms of HIV infection. It works by limiting the spread of HIV in the body. This medication is not a cure for HIV or AIDS and it may still be possible to spread HIV to others while taking it. It does not prevent other sexually transmitted infections (STIs).

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Lexiva

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Diabetes
• Hemophilia
• Kidney disease
• Liver disease
• An unusual or allergic reaction to fosamprenavir, amprenavir, sulfa medications, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

Take this medication by mouth. You can take this medication with or without food. If it upsets your stomach, take it with food. For your therapy to work as well as possible, take each dose exactly as prescribed on the prescription label. Do not skip doses. Skipping doses can make the HIV virus resistant to this and other medications. Keep taking this therapy unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. While it may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose by more than 4 hours, wait and take the next dose at the regular time. But, if you miss a dose by less than 4 hours, take your missed dose right away. Then take your next dose at the regular time. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

• Astemizole
• Bepridil
• Cisapride
• Delavirdine
• Estrogen and progestin hormones
• Flecainide
• Medications for headaches, such as dihydroergotamine, ergonovine, ergotamine, methylergonovine
• Medications for high cholesterol, such as atorvastatin, lovastatin, rosuvastatin, simvastatin
• Midazolam
• Naloxegol
• Pimozide
• Propafenone
• Ranolazine
• Red yeast rice
• Rifampin
• Rifapentine
• St. John's Wort
• Triazolam
• Vitamin E supplements

This medication may also interact with the following:

• Antacids
• Cyclosporine
• Dexamethasone
• Fluticasone
• Medications for blood pressure, such as amlodipine, diltiazem, verapamil
• Medications for depression, anxiety, or mental health conditions, such as lurasidone and quetiapine
• Medications for erectile dysfunction, such as sildenafil
• Medications for fungal infections, such as ketoconazole and itraconazole
• Medications for irregular heartbeat, such as amiodarone, dofetilide, lidocaine, quinidine
• Medications for seizures
• Methadone
• Other medications for HIV
• Rapamycin
• Rifabutin
• Sirolimus
• Tacrolimus
• Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Discuss any new symptoms with your care team. You will need to have important blood work done while taking this medication.

HIV is spread to others through sexual or blood contact. Talk to your care team about how to stop the spread of HIV.

Estrogen and progestin hormones may not work as well while you are taking this medication. If you are using these hormones for contraception, talk to your care team about using a second type of contraception. A barrier contraceptive, such as a condom or diaphragm, is recommended.

This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Hemolytic anemia—unusual weakness or fatigue, dizziness, headache, trouble breathing, dark urine, yellowing skin or eyes
• High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
• Kidney stones—blood in the urine, pain or trouble passing urine, pain in the lower back or sides
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Redness, blistering, peeling, or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Diarrhea
• Fatigue
• Headache
• Nausea
• Stomach pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 15 and 30 degrees C (59 and 86 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer wanted or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substances. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.