Fosphenytoin Injection

What is this medication?

FOSPHENYTOIN (fos FEN i toyn) prevents and controls seizures in people with epilepsy. It may also be used to prevent and treat seizures during or after brain surgery. It works by calming overactive nerves in your body.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Cerebyx

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Alcohol use disorder
  • Asian ancestry
  • Blood disorders or disease
  • Heart disease
  • Kidney disease
  • Liver disease
  • Low blood pressure
  • Suicidal thoughts, plans, or attempt by you or a family member
  • An unusual or allergic reaction to phenytoin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for injection into a vein or muscle or for infusion into a vein. It is given in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as newborns for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

This does not apply.

What may interact with this medication?

Do not take this medication with any of the following:

  • Certain medications used to treat HIV infection or AIDS that are given in combination with cobicistat
  • Delavirdine
  • Ibrutinib
  • Ranolazine

This medication may also interact with the following:

  • Albendazole
  • Alcohol
  • Aspirin and aspirin-like medications
  • Certain medications for blood pressure like nifedipine, nimodipine, and verapamil
  • Certain medications for cancer
  • Certain medications for cholesterol like atorvastatin, simvastatin, and fluvastatin
  • Certain medications for depression, anxiety, or psychotic disturbances
  • Certain medications for fungal infections like ketoconazole and itraconazole
  • Certain medications for irregular heart beat like amiodarone and quinidine
  • Certain medications for seizures like carbamazepine, phenobarbital, and topiramate
  • Certain medications for stomach problems like cimetidine and omeprazole
  • Chloramphenicol
  • Cyclosporine
  • Diazoxide
  • Digoxin
  • Disulfiram
  • Doxycycline
  • Estrogen or progestin hormones
  • Furosemide
  • Halothane
  • Isoniazid
  • Medications that relax muscles for surgery
  • Medications used to treat HIV infection or AIDS
  • Methylphenidate
  • Opioid medications for pain
  • Phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • Praziquantel
  • Reserpine
  • Rifampin
  • St. John's Wort
  • Steroid medications like prednisone or cortisone
  • Sulfonamides like sulfamethoxazole or sulfasalazine
  • Supplements like folic acid or vitamin D
  • Theophylline
  • Ticlopidine
  • Tolbutamide
  • Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Your care team may schedule regular blood tests, because this medication needs careful monitoring. Do not stop using this medication suddenly. This increases the risk of seizures. Because your condition and the use of this medication carry some risk, it is a good idea to carry an identification card, necklace or bracelet with details of your condition, medications and care team.

This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

You may feel dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you more dizzy, increase flushing and may cause rapid heartbeats. Avoid alcoholic drinks.

This medication can cause unusual growth of gum tissues. Visit your dentist regularly. Problems can arise if you need dental work, and in the day-to-day care of your teeth. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

The use of this medication may increase the chance of suicidal thoughts or actions. Pay special attention to how you are responding while on this medication. Any worsening of mood, or thoughts of suicide or dying should be reported to your care team right away.

This medication may cause a decrease in folic acid. You should make sure that you get enough folic acid while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching, hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Infection—fever, chills, cough, or sore throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Pain, swelling, blue or purple skin color at the injection site that spreads
  • Phenytoin toxicity—uncontrollable eye movements, loss of balance or coordination, trouble speaking, unusual weakness or fatigue, nausea, vomiting
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue
  • Swollen lymph nodes in the neck, groin, chest, or underarm area
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Burning or tingling sensation in hands or feet
  • Difficulty with paying attention, memory, or speech
  • Dizziness
  • Drowsiness
  • Headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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