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Fexofenadine; Pseudoephedrine tablets

What is this medication?

FEXOFENADINE; PSEUDOEPHEDRINE (fex oh FEN a deen; soo doe e FED rin) is an antihistamine and a decongestant. This medicine is used to treat or prevent symptoms of allergies.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Allegra-D, Allegra-D 12 Hour Allergy & Congestion, Allegra-D 24 Hour Allergy & Congestion, Antihistamine & Nasal Decongestant

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • diabetes
  • glaucoma
  • heart disease
  • high blood pressure
  • kidney disease
  • problems urinating
  • prostate disease
  • taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • thyroid disease
  • an unusual or allergic reaction to fexofenadine, pseudoephedrine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

Swallow this medicine with a glass of water. Do not break, crush, or chew. Follow the directions on the prescription label. Take the tablet on an empty stomach, one hour before or two hours after a meal. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 60 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medicine with any of the following medications:

  • antihistamines and other medicines for allergy, cough and cold
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • herbal or dietary supplements containing ephedra or ephedrine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • antacids
  • bromocriptine
  • certain medicines for depression
  • digoxin
  • erythromycin
  • grapefruit, apple, or orange juice
  • linezolid
  • ketoconazole
  • magnesium products
  • methyldopa
  • reserpine
  • stimulant medicines for attention disorders, weight loss, or to stay awake
  • yohimbine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Visit your doctor or health care professional for regular check ups. Tell your doctor or health care professional if your symptoms do not improve. If you have high blood pressure, check your blood pressure regularly. Ask your health care professional what your blood pressure should be, and when you should contact them.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

The tablet shell for some brands of this medicine does not dissolve. This is normal. The tablet shell may appear whole in the stool. This is not a cause for concern.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in vision
  • dizziness
  • eye pain
  • fast, irregular heartbeat
  • high blood pressure
  • nervousness
  • restlessness
  • seizures
  • tremor
  • trouble passing urine or change in the amount of urine
  • trouble sleeping
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dry mouth
  • headache
  • loss of appetite
  • nausea
  • sore throat
  • tiredness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 20 to 25 degrees C (68 and 77 degrees F). Protect from moisture. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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