Bacteria in soil and water cause MAC lung disease in people with compromised immune systems or respiratory problems. Symptoms vary from person to person. Most people need different antibiotics for more than a year to help clear the infection. In serious cases, you may need surgery.
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MAC lung disease is a type of long-term (chronic) infection that affects your lungs. The Mycobacterium avium complex (MAC) group of microbes causes MAC lung disease. It can be difficult to treat if you don’t get a diagnosis quickly.
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MAC bacteria are a type of nontuberculous mycobacteria (NTM) that naturally live in dust, soil and water. It’s the most common type of nontuberculous mycobacteria (NTM) infection. More than 86,000 people in the U.S. have some type of NTM infection, and MAC accounts for almost 8 out of 10 NTM infections. The rates have steadily grown over the last two decades. Healthcare providers expect the rates to keep increasing.
Most people who breathe in or swallow MAC bacteria don’t get sick. But some health conditions increase your chances of developing it. MAC lung disease is sometimes fatal.
MAC infections include:
There are two types of MAC lung disease:
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This is a milder form and more common. An infection develops in the small airways and air sacs in your lungs. It causes pulmonary nodules that are visible in imaging tests, like CT scans. Tiny nodules aren’t always visible in chest X-rays. The nodules grow slowly. Long-lasting inflammation causes your airways to permanently widen (dilate). Healthcare providers call this bronchiectasis. This makes it harder for your body to clear infections. It also increases your risk of new infections.
This type is more common in females who’ve completed menopause and don’t smoke.
This is the more severe form of MAC lung disease. It’s less common and harder to treat. It’s a deeper infection that causes a hole in your lung tissue. You need treatment as soon as possible if you have fibrocavitary disease.
You’re more likely to have fibrocavity disease if you smoke or have emphysema.
MAC lung disease symptoms may include:
MAC lung disease symptoms vary. You may not have the same symptoms as someone else who has the condition. The symptoms are also often nonspecific. That means if you do have symptoms, they’re broad — they may be symptoms of a wide range of conditions.
MAC bacteria naturally live in soil. Stirring up soil or dust, like through gardening or playing outside, can send bacteria into the air, where you may breathe them in.
MAC also naturally live in water. This includes the water in your home, even showerheads and hot tubs.
It’s important to remember that for most people, the bacteria are harmless. We encounter nontuberculous mycobacteria every day, and most people never develop an infection.
But in a small number of people who have certain risk factors, the bacteria settle in their lungs. It then grows slowly, often over many years. The resulting MAC lung infection causes minor inflammation and permanent changes to your airways. The changes may continue until a healthcare provider can diagnose it and provide treatment.
MAC lung disease can affect anyone. But certain people face a higher risk. You’re at a greater risk if you’re over 65 and have gone through menopause.
You’re also more likely to get MAC lung disease if you smoke, have a weakened immune system or a lung condition such as:
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A history of tuberculosis (TB) also increases your odds of getting MAC lung disease.
No, you can’t catch a MAC infection from someone else. But sometimes, MAC lung disease affects more than one biological family member. Experts believe certain people have a genetic variation that makes them more likely to get a MAC infection.
A healthcare provider will review your medical history, ask about your symptoms and perform a physical exam. If they suspect MAC lung disease, they’ll recommend tests. These tests may include:
MAC lung disease can be challenging to diagnose. A provider may refer you to an infectious disease doctor or a lung specialist (pulmonologist).
MAC lung disease can be challenging to treat. But healthcare providers can cure it. Your odds are better if you have nodular bronchiectasis and get an early diagnosis.
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MAC lung disease treatment depends on how bad your symptoms are. Healthcare providers may recommend:
Taking antibiotics to treat MAC lung disease can cause side effects. Some common effects include:
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It’s important to take your full course of antibiotics to treat MAC lung disease. But it can be difficult to take them for such a long time, especially if you develop symptoms. Talk to a healthcare provider if antibiotic side effects bother you. They can recommend ways to help manage them.
Reach out to your healthcare provider if you’re sick or have new or worsening symptoms after a MAC lung disease diagnosis.
You may wish to ask them the following questions:
MAC lung disease can be tough to treat. Most people need to take several antibiotics for at least a year. While you’re taking antibiotics, you’ll have regular check-ups with your healthcare provider. They’ll make sure the medicine is working and adjust your dosage or medication if needed.
Providers consider the infection gone if your sputum cultures stay clear for 12 months. But MAC can come back. This may happen after another exposure. It can also happen if some mycobacteria are still hiding in your lungs. You’re at a higher risk if you have other health problems that make it easier for you to get sick.
If MAC causes lung damage, it usually doesn’t heal. So, after treatment, you may still have breathing problems. Before you start treatment, your provider will talk to you about what to expect and what the goals are for your care.
In some people, MAC lung disease can cause respiratory failure and death. But getting a diagnosis and starting treatment as soon as possible helps reduce the long-term risks.
It depends on many factors. These include the severity of your case of MAC lung disease, any other conditions you may have (comorbidities) and your overall health. A healthcare provider will give you a better idea of what to expect.
You can help ease MAC lung disease symptoms by:
MAC bacteria are common, and most people who encounter MAC bacteria won’t get sick. But you can help lower your risk of exposure by:
MAC bacteria are common in the environment, and they don’t cause illness in most people. But you’re more likely to get MAC lung disease if you have a weakened immune system or another lung condition. Be sure to let your healthcare provider know as soon as possible about any new or developing respiratory symptoms. These include chronic cough with or without phlegm, fatigue and low-grade fevers. Early diagnosis and treatment increase your odds of successful treatment.
If you have preexisting lung disease, such as bronchiectasis or emphysema, healthcare providers will give you tips on how to protect yourself from infection.
Have a virus, fungus or bacteria? Some of these “bugs” won’t go away on their own. Cleveland Clinic’s infectious disease experts are here to help.
Last reviewed on 07/14/2025.
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