Your sphenoid sinuses are the paranasal sinuses within your skull behind the upper part of your nasal cavity. They contain cells that make mucus that drains into your nasal cavity. The mucus flushes out harmful substances and keeps the lining of your nose healthy. Inflammation in just your sphenoid sinuses is called sphenoid sinusitis.
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Your sphenoid sinuses are a pair of air-filled cavities inside your skull. They’re one of four paranasal sinuses (or just “sinuses,” as most people call them). Your paranasal sinuses are your: frontal sinuses, ethmoid sinuses, sphenoid sinuses and maxillary sinuses. They’re all arranged around your nasal cavity. Of all your sinuses, your sphenoid sinus is the farthest back in your skull.
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Your sphenoid sinuses make mucus that clears germs and allergens out through your nose. Rarely, they can get infected. When this happens, it’s important to seek treatment to prevent the infection from spreading to nearby structures, like your brain or eye sockets.
Your sphenoid sinus makes mucus that traps and flushes out germs that might otherwise make you sick. The mucus also keeps the lining of your nasal cavity warm, moist and healthy. In this way, your sphenoid sinuses help humidify the air you breathe.
Doctors are still learning about all the jobs your sphenoid sinus does. Other potential functions include:
Your sphenoid sinuses are inside your sphenoid bone. It’s a butterfly-shaped bone that’s between the bones in your face and other bones deeper in your skull. Your sphenoid sinuses are located behind the upper part of your nasal cavity, just about in the center of your head.
Your sphenoid sinuses are close to key structures. They’re near your:
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Surgeons sometimes use the sphenoid sinus to access the pituitary gland and remove tumors. During transsphenoidal surgery, a surgeon can look through your nose and into your sphenoid sinus using a small telescope. This access point prevents surgeons from having to make incisions (cuts) on your face or scalp to remove tumors.
You have two sphenoid sinus cavities: a left sphenoid sinus and a right sphenoid sinus. They’re separated by a thin bony wall. But the wall isn’t a straight vertical line that divides your sinuses evenly. This means that your left and right sphenoid sinuses aren’t mirror images of each other. Instead, one may be much bigger than the other. Their size varies depending on your age, sex and ethnicity.
The mucus from your sphenoid sinuses drains into the sphenoethmoidal recess. This structure sits inside another one called the superior meatus. It’s located in the back of your nose, just in front of your sphenoid sinus. Parts of your ethmoid sinus also drain here.
Germs or allergens that get trapped in your sphenoid sinuses can cause inflammation, or tissue swelling. Inflammation in your sphenoid sinuses is called sphenoid sinusitis. The swelling can block your sinus passages and cause germs to get stuck. This can lead to a sinus infection. Usually, when your sphenoid sinuses are infected, nearby sinuses like your ethmoid and frontal sinuses are involved, too.
Although it’s rare for just your sphenoid sinuses to get infected, it can happen. Most sphenoid infections are caused by bacteria. Rarely, fungi play an infectious role. Bacterial infections of the sphenoid sinus can be serious without treatment because these sinuses are so close to your brain and optic nerves.
An infection in your sphenoid sinus can lead to:
Benign, precancerous and cancerous growths can also form in your sphenoid sinus, but these are rare.
Since your sphenoid sinus is deep within your skull, it doesn’t usually cause symptoms typical of sinus infections, like a stuffy or runny nose. Symptoms of a sphenoid sinus infection, inflammation, or growth are more likely to cause:
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The same steps you take to prevent colds and allergic reactions, in general, can protect your sphenoid sinuses. Getting enough sleep, exercising regularly and eating nutritious foods can help reduce your risk of getting sick. Good handwashing hygiene and taking precautions around people who are sick help, too.
If you suspect your sphenoid sinuses are clogged, there are things you can do to help clear them. You can try:
As these sinuses are so close to important structures, it’s important to see a healthcare provider if you’re experiencing signs of sphenoid sinusitis. They may need to drain your sphenoid sinuses to prevent the infection from spreading.
While most sinus infections eventually clear on their own, if two weeks have passed and things aren’t better, it’s time to see a healthcare provider.
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Your sphenoid sinuses work with your other paranasal sinuses to flush germs out of your nose. They’re part of your body’s natural drainage system that can keep you from getting sick. But infections can happen. And untreated infections in your sphenoid sinuses can cause issues if they spread. This is why it’s important to take every precaution to keep from getting sick. If you have a sinus infection that lasts for more than two weeks, contact a healthcare provider.
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Constant stuffiness, sinus pressure and pain can wear you out. But you don’t have to live with it. Cleveland Clinic sinus surgery experts can help you get relief.
Last reviewed on 03/12/2025.
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