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Advanced Practice Registered Nurse (APRN)

Medically Reviewed.Last updated on 02/10/2026.

Advanced practice registered nurses (APRNs) play a critical role in healthcare. Their high-level certification opens the door to several different careers. APRNs can be nurse practitioners providing everyday care, like annual wellness exams. Or they can offer very specialized services, like giving you anesthesia during a surgery or delivering babies.

What is an advanced practice registered nurse?

Advanced practice registered nurses (APRNs) are nurses with additional education, training and experience. That means they can practice at a higher level than other nurses, like licensed practical nurses (LPNs) or registered nurses (RNs).

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To become an APRN, a registered nurse has to earn at least a master’s degree in nursing. Some nurses go even further with their education and earn a Doctor of Nursing Practice (DNP) degree. APRNs also have to complete hundreds of hours of additional training. Then, they have to earn a board certification in their specialty field.

APRNs can do any of the following, depending on the area they focus on:

  • Provide primary care, like annual check-ups or office sick visits.
  • Provide acute care, like in a hospital or clinic setting.
  • Provide mental health services.
  • Diagnose and treat conditions.
  • Assist in surgeries.
  • Deliver babies and provide care in other areas of Ob/Gyn.
  • Refer you to a specialist.
  • Prescribe medications (varies by state) and provide treatments (varies by specialty).
  • Deliver anesthesia.
  • Hold leadership positions.

What is the role of an advanced practice registered nurse?

APRNs can be nurse practitioners, but that’s not their only career choice. In fact, becoming an APRN can open the door to the following four career paths

What can APRNs specialize in?

APRNs can specialize in many different areas. The main specialties are:

  • Adult-gerontology
  • Family practice
  • Gynecology and obstetrics
  • Pediatrics
  • Neonatal
  • Psychiatric/mental health

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Other terms for APRNs

Not all states call APRNs the same thing. Some states call them advanced practice nurses (APNs) or advanced registered nurse practitioners (ARNPs). One state uses “nurse practitioner” to mean APRN, even though they’re not exactly the same. And one state has no term.

The licensing, certification and certain education requirements can also vary from state to state.

Can an advanced practice registered nurse prescribe medication?

Sometimes, but it varies from state to state. Most states let APRNs prescribe independently. Several states only let some APRNs prescribe independently. And a handful of states don’t let APRNs prescribe independently at all.

What are the key differences between an advanced practice registered nurse and a registered nurse?

There are several key differences between an RN and an APRN. Those include:

  • Education: Becoming an APRN takes additional education. RNs must have either an associate’s degree or a bachelor’s degree in nursing. APRNs must have a master’s degree or higher.
  • License exam: RNs take the NCLEX for registered nurses (NCLEX-RN). APRNs must be board-certified in their specialty.
  • Scope of practice: APRNs offer more types of care than RNs can.
  • Independence: RNs can’t practice on their own. APRNs can practice on their own in some states. Other states require varying levels of physician collaboration or supervision, depending on state law.
  • Prescribing authority: RNs can’t prescribe medicines. APRNs can prescribe, depending on state laws.

Is an APRN like a doctor?

There’s some overlap in what APRNs and doctors do, especially in certain roles and settings. For example, nurse practitioners and certified nurse midwives often provide primary care services, like diagnosing conditions, prescribing medications and managing ongoing care.

Clinical nurse specialists typically work in specialty or hospital-based roles rather than serving as primary care providers. Certified registered nurse anesthetists provide anesthesia care and do many of the same clinical functions as physician anesthesiologists, though their training paths and scopes of practice differ.

A note from Cleveland Clinic

Advanced practice registered nurses (APRNs) are nurses who choose to take their careers to the next level. They can do your annual physical, give you anesthesia before and during a surgery, deliver babies and so much more. Many APRNs also take leadership jobs, helping improve healthcare for millions.

Nursing is a challenging field to begin with. And APRNs take it further, expanding their education and completing hundreds of training hours. Doing that means they can offer a wider range of services and care. And the care they can provide can make a huge difference in your health and well-being.

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Medically Reviewed.Last updated on 02/10/2026.

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