BioRepository Resources & Services

BioRepository Resources & Services


To safely maximize the value of human samples by supplying high quality, well-annotated specimens to researchers whose discoveries will be essential for the evolution of personalized medicine.


  • Blood and blood products (DNA, RNA, packed cells, plasma, serum, PBMCs).
  • Urine.
  • Stool.
  • Tissue (including paraffin blocks, frozen sections and fresh frozen).
  • Key medical record data.
  • Patient-reported outcomes.


The following services are available for projects that have been approved by Cleveland Clinic’s BioRepository Review Committee.

  • Identification and collection of residual tissue and blood or prospectively collected blood and other bodily fluids (urine, saliva, joint fluid, ascites, etc.) using uniform operating procedures and standardized collection kits.
  • Pre-analytic specimen processing under a standardized and annotated process in a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory.
  • Phenotypic data collection for each sample procured.
  • Quality assurance of specimens according to College of American Pathology (CAP) guidelines.

External Collaborations

Please note that external researchers must have a collaborator from Cleveland Clinic to request the resources and services outlined above. All services/collaborations will need to be approved by CCBioR Review Committee. For more information, please contact Cleveland Clinic’s BioRepository at 216.445.1123.

For Cleveland Clinic researchers who wish to use the CC-BioR, visit the BioRepository intranet.

Enrollment & Demographics

Enrollment & Demographics

Specimens are collected via enrollment in three parallel paths:

  • Surgery
    The collection of paired tissue and blood. These are redundant specimens, meaning all clinical testing has been resulted and the material would otherwise be discarded.
  • Outpatient Labs
    The collection of residual blood. These are redundant specimens, meaning all clinical testing has been resulted and the material would otherwise be discarded.
  • Active Recruitment*
    The collection of fresh samples. These are fresh specimens collected for research only, facilitating proteomics, RNA and cell-based studies that require fresh samples.

*In May 2020 we began collecting blood, urine and stool from COVID-19 positive patients and have since expanded our collection to include a COVID-19 negative cohort as well. These patients are included in the demographics summarized below.


Cleveland Clinic’s BioRepository aims to collect specimens from a diverse pool of participants to reflect the diversity in our communities.

We collect specimens that are varied in age, sex, race and clinical diagnoses.

View recent demographics (updated 4/21/23). To access more recent data, please contact us.