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Elbasvir; Grazoprevir Oral Tablet

Elbasvir grazoprevir is an oral medication that treats hepatitis C. Hepatitis C is a condition that causes liver inflammation and liver damage. The medicine works by reducing the amount of hep C in your body.

What is this medication?

ELBASVIR; GRAZOPREVIR (el' bas vir; graz oh' pre vir) treats hepatitis C. It is 2 antiviral medications in 1 tablet. It will not treat colds, the flu, or other viral infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): ZEPATIER

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Diabetes (high blood sugar)
  • Have ever taken any medication for hepatitis C
  • History of hepatitis B infection
  • History of or waiting for a liver transplant
  • HIV or AIDS
  • Other liver disease
  • An unusual or allergic reaction to elbasvir, grazoprevir, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with a full glass of water. You can take it with or without food. If it upsets your stomach, take it with food. For your therapy to work as well as possible, take each dose exactly as prescribed on the prescription label. Do not skip doses. Keep taking this therapy unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. While it may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following medications:

  • Certain antiviral medications for HIV or AIDS like atazanavir, darunavir, efavirenz, lopinavir, saquinavir, tipranavir
  • Certain medications for seizures like carbamazepine, phenytoin
  • Cyclosporine
  • Enasidenib
  • Rifampin
  • St. John's Wort

This medication may also interact with the following medications:

  • Bosentan
  • Certain antiviral medications for HIV or AIDS like cobicistat, elvitegravir, emtricitabine, tenofovir, etravirine
  • Certain medications for cholesterol like atorvastatin, fluvastatin, lovastatin, rosuvastatin, simvastatin
  • Certain medications for diabetes
  • Ketoconazole
  • Modafinil
  • Nafcillin
  • Tacrolimus
  • Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. You may need blood work while you are taking this medication.

This medication may cause changes in your blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Fatigue
  • Headache
  • Nausea
  • Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature below 20 to 25 degrees C (68 to 77 degrees F). Keep this medication in the original packaging until you are ready to take it. Protect from moisture. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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