The Neuromuscular Center, headed by Dr. Yuebing Li since 2021, provides diagnosis and management as well as various research studies for hundreds of patients annually with ALS, MG, CIDP, MMN IMNM, polyneuropathies and autonomic disorders from Ohio and elsewhere. An average of 6 patients are newly diagnosed with a MND weekly at the Cleveland Clinic Neuromuscular Center, and approximately 350 ALS patients are provided ongoing care at any one time, primarily in the Cleveland Clinic ALS/MND Team Clinic (an ALS Association Center of Excellence), directed by Dr. Rebecca M Kuenzler. A total of 1300 patients with MG, 400 patients with CIDP and 400 patients with IMNM have received care at our Neuromuscular Center during the last ten years. Present research efforts are aimed at testing potential clinical therapies, characterizing the natural history of disease through data analyses, identifying genetic and environmental factors predisposing disease development. The role of artificial intelligence (AI) in the diagnosis and management of neuromuscular disorders is being explored.

Contact person:

Yuebing Li MD PhD


Massachusetts General Hospital/Calico Life Sciences, LLC
Janssen Research & Development, LLC
Immunovant Sciences GmbH



(in past 2 years)

Samantha J Stallkamp Todd, Amy S. Nowacki, Tamanna Singh, Anna Hayburn, Robert Wilson. Comorbid anxiety is associated with more changes in the management of Postural Orthostatic Tachycardia Syndrome. General Hospital Psychiatry , Volume 87, March -April 2024, pages 1-6.

Meiling JB, Andrapalliyal N, McGhee MB, Penry VB, Cartwright MS, Gandhi Mehta RK. Ultrahigh-frequency ultrasound of fascicles in the common fibular, superficial fibular, and sural nerves. Muscle Nerve. 2024 May;69(5):631-636. doi: 10.1002/mus.28078. Epub 2024 Mar 8. PMID: 38456323.

Claytor B, Li Y. Quantifying adverse events: The burden is on us! Muscle Nerve. 2024 Jan;69(1):1-3. doi: 10.1002/mus.27988. Epub 2023 Oct 20. PMID: 37863842.

Sanghani N, Claytor B, Li Y. Electrodiagnostic findings in amyotrophic lateral sclerosis: Variation with region of onset and utility of thoracic paraspinal muscle examination. Muscle Nerve. 2024 Feb;69(2):172-178. doi: 10.1002/mus.28012. Epub 2023 Dec 1. PMID: 38038225.

Hill J, Sanghani N, Li Y. Features Suggestive of Coexisting Amyotrophic Lateral Sclerosis in Patients With Spinal Stenosis and Influence of Spinal Decompression. Cureus. 2024 Jan 3;16(1):e51587. doi: 10.7759/cureus.51587. PMID: 38313873; PMCID: PMC10836407.

Taha MA, Morren JA. The role of artificial intelligence in electrodiagnostic and neuromuscular medicine: Current state and future directions. Muscle Nerve. 2024 Mar;69(3):260-272. doi: 10.1002/mus.28023. Epub 2023 Dec 27. PMID: 38151482.

Uysal SP, Li Y, Thompson NR, Milinovich A, Abbatemarco JR, Cohen JA, Conway DS, Ontaneda D, Morren JA, Kunchok A. Predicting disability and mortality in CV2/CRMP5-IgG associated paraneoplastic neurologic disorders. Ann Clin Transl Neurol. 2024 Jan 22. doi: 10.1002/acn3.51991. Epub ahead of print. PMID: 38251800.

Cantrell C, Reid C, Walker C, Tidd S, Zhang R, Wilson R. Post-COVID Postural Orthostatic Tachycardia Syndrome (POTS): A New Phenomenon. An Update on Neurological Disorders Post COVID-19 Infection Vol 2: cardiovascular effects, neuro-cardiac and neuro-respiratory autonomic dysfunctions. Volume 15 - 2024 | doi: 10.3389/fneur.2024.1297964

Palmer K, Sokola M, Uysal SP, Cooperrider J, Leung A, Torres-Trejo A, Li Y, Abbatemarco J. Diagnostic Challenges of Lyme Neuroborreliosis in Inpatient Neurology: A Case Series. Accepted by The Neurohospitalist.

Conway J, Bhansali S, Li Y. A Case of Very Late Onset Spinobulbar Muscular Atrophy with Normal Creatine Kinase. Accepted by RRNMF Neuromuscular Journal.

The Netter Collection of Medical Illustrations, Frank N. Netter MD. Nervous System, Volume 7, Part I—Brain. 3rd edition. Aminoff MJ, Pomeroy SL, Levin KH (eds). Philadelphia. Elsevier. 2024.

The Netter Collection of Medical Illustrations, Frank N. Netter MD. Nervous System, Volume 7, Part II—Spinal Cord and Peripheral Motor and Sensory Systems. 3rd edition. Aminoff MJ, Pomeroy SL, Levin KH (eds). Philadelphia. Elsevier. 2024

Narayanaswami P, Sanders DB, Thomas L, Thibault D, Blevins J, Desai R, Krueger A, Bibeau K, Liu B, Guptill JT; PROMISE-MG Study Group. Comparative effectiveness of azathioprine and mycophenolate mofetil for myasthenia gravis (PROMISE-MG): a prospective cohort study. Lancet Neurol. 2024 Mar;23(3):267-276. doi: 10.1016/S1474-4422(24)00028-0. PMID: 38365379.

Morren JA, Rheaume C, Pioro EP. Self-reported factors contributing to delay in ALS diagnosis among primary care providers in a large Ohio-based US healthcare network. J Neurol Sci. 2023 Feb 15;445:120532. doi: 10.1016/j.jns.2022.120532. Epub 2022 Dec 25. PMID: 36628902.

Zust C, Morren JA. What are the treatment options for myasthenia gravis if first-line agents fail? Cleve Clin J Med. 2023 Feb 1;90(2):81-84. doi: 10.3949/ccjm.90a.22022. PMID: 36724916.

Morren JA, Li Y. Myasthenia gravis: Frequently asked questions. Cleve Clin J Med. 2023 Feb 1;90(2):103-113. doi: 10.3949/ccjm.90a.22017. PMID: 36724914.

Thakore NJ, Pioro EP. Letter to Editor. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Feb;24(1-2):157-158. doi: 10.1080/21678421.2022.2136995. Epub 2022 Oct 26. PMID: 36286007

Taha M, Li Y, Morren J. Oxymetazoline Hydrochloride Eye-Drops as Treatment for Myasthenia Gravis-Related Ptosis: A Description of Two Cases. Cureus. 2023 Mar 19;15(3):e36351. doi: 10.7759/cureus.36351. PMID: 37082493; PMCID: PMC10111874.

Bireley JD, Morren JA. CNM-Au8: an experimental agent for the treatment of amyotrophic lateral sclerosis (ALS). Expert Opin Investig Drugs. 2023 Jul-Dec;32(8):677-683. doi: 10.1080/13543784.2023.2252738. Epub 2023 Sep 1. PMID: 37642362.

Aron Gedansky, MD; Matthew Kaufman, BAS; Bhageerath Mulpur, MD; Robert Wilson, DO; Gabor Toth, MD/ American Journal of Neuroradiology Case of the week: 70 year-old man presents with fatigue and progressive gait difficulty July 01. 2023 ,Volume 44 , Issue 7

Stallkamp Tidd S J, Cantrell C, Greene B D, Wilson R. (August 13, 2023) Low-Dose Naltrexone Use in Postural Orthostatic Tachycardia Syndrome: A Case Series. Cureus 15(8): e43426. doi:10.7759/cureus.43426

Andrapalliyal N, Claytor B, Li Y. Incidence and causes of overdiagnosis of myasthenia gravis. Muscle Nerve. 2023; 67: 464-468.

Claytor B, Cho SM, Li Y. Myasthenic crisis. Muscle Nerve. 2023; 68: 8-19.

Kovacevich A, Weleff J, Claytor B, Barnett BS. Three Cases of Reported Improvement in Microsmia and Anosmia Following Naturalistic Use of Psilocybin and LSD. J Psychoactive Drugs. 2023 Aug 31:1-8. doi: 10.1080/02791072.2023.2253538. Epub ahead of print. PMID: 37650700.

Longinow J, Zmaili M, Skoza W, Kondoleon N, Marquardt R, Calabrese C, Funchain P, Moudgil R. Immune checkpoint inhibitor induced myocarditis, myasthenia gravis, and myositis: A single-center case series. Cancer Med. 2023 Feb;12(3):2281-2289. doi: 10.1002/cam4.5050. Epub 2022 Sep 21. PMID: 36128926; PMCID: PMC9939107.
Aboseif A, Bireley JD, Li Y, Polston D, Abbatemarco JR. Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management. Cleve Clin J Med. 2023 Jul 3;90(7):439-447. doi: 10.3949/ccjm.90a.22093. PMID: 37400156.

Tawfik EA, Cartwright MS, van Alfen N, Axer H, Boon AJ, Crump N, Grimm A, Hobson-Webb LD, Kerasnoudis A, Mandeville R, Preston DC, Sakamuri S, Shahrizaila N, Shin S, Shook SJ, Wilder-Smith E, Walker FO. Neuromuscular ultrasound standardized scanning techniques and protocols: Expert panel recommendations. Muscle Nerve. 2023 Apr 19. doi: 10.1002/mus.27830. Epub ahead of print. PMID: 37074101.

Heber M, Li Y. Caution on LRP4 antibody results in patients being evaluated for myasthenia gravis. J Neuroimmunol. 2023;377:578063.

Hill J, Li, Y. Myasthenia Gravis Exacerbation Following BRAF and MEK Inhibitor Therapy. RRNMF Clinical Neuromuscular Journal. 2023: 4(2); 16-17.

Bireley JD, Santucci J, Li Y, Cohen DA. Clinical Reasoning: An Unusual Cause of Diplopia and Ptosis in a 67-Year-Old Woman. Neurology. 2023 Oct 17;101(16):e1646-e1651. doi: 10.1212/WNL.0000000000207676. Epub 2023 Aug 1. PMID: 37527939; PMCID: PMC10585670.

Howard JF Jr, Bresch S, Genge A, Hewamadduma C, Hinton J, Hussain Y, Juntas-Morales R, Kaminski HJ, Maniaol A, Mantegazza R, Masuda M, Sivakumar K, Śmiłowski M, Utsugisawa K, Vu T, Weiss MD, Zajda M, Boroojerdi B, Brock M, de la Borderie G, Duda PW, Lowcock R, Vanderkelen M, Leite MI; RAISE Study Team. Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Neurol. 2023 May;22(5):395-406.

Members & Collaborations

Members & Collaborations

Cleveland Clinic

  • Nirmal Andrapalliyal, MD
  • David Bruckman, MS
  • Benjamin Claytor, MD
  • Stephen Jones, MD PhD
  • Feng Lin, PhD
  • John Morren, MD
  • David Polston, MD
  • Danielle Richards, MD
  • Nimish Thakore, MD

External Relationships and Collaborations

  • Michael Hehir, MD
  • Ikjae Lee, MD
  • Nicholas Silverstri, MD