Center for Cardiovascular Genomics and Data Science
Transforming the Future of Heart Care Through Genomics and Data-Driven Discovery
The Center for Cardiovascular Genomics and Data Science is pioneering the next generation of precision cardiovascular medicine, using genomics, large-scale data and translational science to better understand inherited risk and deliver more personalized care for patients and families.Working in concert with the Haslam–Bailey Family Section of Cardiovascular Genomics and Precision Medicine, the Center bridges scientific discovery and clinical application, ensuring that advances in genomic research rapidly and responsibly reach the patients who need them most.
About the Center
Many cardiovascular diseases — including atherosclerosis, cardiomyopathy, arrhythmias and aortic disease — have a significant inherited component. Through advanced genomic research, data science and population-based discovery, the Center seeks to define how genetic variation influences disease risk, presentation and outcomes across diverse populations.
The Center’s mission is to bridge genomic discovery and clinical practice. By combining large-scale genomic and clinical data with advanced analytics, we study how genetic variation shapes cardiovascular disease risk and progression, laying the groundwork for more precise prevention and treatment.
As the research arm of Cleveland Clinic’s genomics initiative, the Center works closely with the Haslam–Bailey Family Section of Cardiovascular Genomics and Precision Medicine. Patients seen in the Section are uniquely positioned to both shape and benefit from this partnership, simultaneously helping drive research questions that arise from real-world care and receiving answers that can be translated back into practice more rapidly. This integration also enables participation in ongoing studies and clinical trials exploring innovative screening strategies and data-driven approaches to prevention and disease management.
Focus Areas
Discovery Genomics:
Identifying genes and variants underlying inherited and acquired cardiovascular diseases.
Translational Genomics:
Evaluating how new genomic discoveries can inform risk assessment, diagnosis and treatment.
Genomic Risk Prediction:
Developing and validating tools for predicting disease risk and clinical outcomes.
Implementation Research:
Assessing the value, accessibility and real-world impact of genomic testing in clinical care.
Healthcare Access in Genomics:
Expanding representation in genomic research to ensure that precision medicine benefits all populations.
Leadership
Director: Krishna G. Aragam, MD, MS
William E. Macaulay Endowed Chair in Cardiovascular Genomics
Section Head, Cardiovascular Genomics and Precision Medicine
Dr. Aragam is a cardiologist, physician-scientist and internationally recognized leader in cardiovascular genomics. His research has identified key genetic contributors to heart failure, cardiomyopathy and coronary artery disease, shaping emerging strategies for genomic risk prediction and precision prevention.
As founding Director of the Center for Cardiovascular Genomics and Data Science, Dr. Aragam leads a multidisciplinary effort to integrate genomic discovery, data science and translational research into Cleveland Clinic’s cardiovascular program—accelerating the path from genetic insight to improved patient outcomes. Prior to joining Cleveland Clinic, he led investigative programs in cardiovascular genomics at Massachusetts General Hospital and the Broad Institute of MIT and Harvard, where his work focused on large-scale genomic discovery and population-based approaches to precision cardiovascular medicine.
Collaborators
The Center is housed within the Heart, Vascular & Thoracic Institute and collaborates across Cleveland Clinic to advance discovery and translation in cardiovascular genomics. The Center works closely with the C5 Research Center (Cleveland Clinic Coordinating Center for Clinical Research) to integrate genomic insights into clinical trials and precision medicine studies. It also partners with colleagues in the Genomic Medicine Institute and Cleveland Clinic Research (formerly named Lerner Research Institute) to extend discoveries from genomic and data science into clinical application. Beyond Cleveland Clinic, the Center engages with national and international research consortia to drive large-scale genomic discovery, data sharing and equitable implementation of precision cardiovascular medicine.
