A Small Knee Bump Led to a Rare Sarcoma Cancer Diagnosis — and Lifesaving Care

When Maxine Edwards asked her primary care doctor about a bump on her knee, she never suspected it could be tied to a rare form of cancer. Her persistence in following up, under the guidance of her doctor, saved her leg – and probably her life.

Sarcoma is a rare cancer that originates in connective tissues such as muscles, fat, blood vessels, nerves, and bones. According to the American Cancer Society, sarcomas account for less than 1% of all adult cancers, with about 13,000 new U.S. cases annually.

This rarity makes diagnosis and treatment challenging, often requiring specialized orthopedic oncology care.

A Tamarac, Florida resident originally from Jamaica, Mrs. Edwards’ journey began with that bump in her right knee. Her doctor listened and made the right call. This is a story about the importance of seeking medical care, building trust with doctors, and the critical role of skilled specialists in treating rare cancers like sarcoma.

Elusive Diagnosis and Compassionate Care

Mrs. Edwards visited her primary care physician, who recognized the need for specialized evaluation. An MRI revealed a solid mass, prompting a referral to orthopedic oncologist Jorge Manrique-Succar, MD, director of the sarcoma program at Cleveland Clinic in Florida.

Although the likelihood of cancer was low, he recommended a biopsy in January 2020. Results showed a myxofibrosarcoma, a soft tissue sarcoma affecting connective tissues in the limbs.

“Dr. Manrique spoke to me in such a way that I had complete confidence in him, and I knew that he could help me,” Mrs. Edwards recalled. “I didn’t cry. He was so kind that I had no fear. I only had acceptance, and his explanation was clear. I appreciate and trust him.”

Treatment included 25 radiation sessions over five weeks before surgery to reduce micro metastasis. The combination of radiation and surgery proved effective, leaving her cancer-free. A Cleveland Clinic plastic surgeon assisted with scar care and arranged at-home recovery support during the Covid-19 pandemic. Dr. Manrique also explained her situation to her daughter Natalya in Texas, underscoring his patient-centered approach.

Life After Sarcoma and Renewed Hope

Today, Mrs. Edwards walks unaided for 15 minutes at a time, drives, shops, and lives independently. “I am blessed,” she said, crediting Cleveland Clinic Weston’s multidisciplinary tumor board for its role in her care. “No matter the situation, we want patients to know they are not alone on their health journeys; we are here for them every step of the way,” says Dr. Manrique.