Treprostinil Dry Powder Inhaler (Yutrepia DPI)

What is this medication?

TREPROSTINIL (tre PROST in il) treats pulmonary arterial hypertension (PAH), a condition that causes high blood pressure in the lungs. It works by relaxing your blood vessels and lowering the blood pressure in your lungs, which makes it easier for your heart to pump blood to the rest of your body. It can also help you breathe easier and be more active.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Yutrepia

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Liver disease
• Low blood pressure
• Lung or breathing disease, such as asthma or COPD
• Wheezing or trouble breathing
• An unusual or allergic reaction to treprostinil, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

How should I use this medication?

This medication is inhaled through the mouth. Do not swallow the capsules. Take it as directed on the prescription label. Do not use it more often than directed. Keep taking it unless your care team tells you to stop.

Each blister strip contains a capsule and a drying agent (desiccant) to keep the capsule dry. Throw away the blister strip and desiccant tablet after removing the capsule. Do not eat or swallow the desiccant.

This medication must only be used in the Yutrepia DPI Inhaler. Replace the inhaler device every 7 days or after 56 capsules are used, whichever comes first.

This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medication. Read the information carefully. Talk to your pharmacist or care team if you have questions.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

• Gemfibrozil
• Rifampin
• Some medications for blood pressure or heart disease

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Before having surgery, dental work, or another procedure, tell your care team that you are taking this medication.

Avoid sports and activities that may cause injury while you are taking this medication. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your care team.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
• Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
• Wheezing or trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Cough
• Diarrhea
• Dizziness
• Facial flushing, redness
• Headache
• Irritation in the throat
• Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Unopened blister cards or strips: Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medication in the original packaging until you are ready to take it. Once removed from the blister card, capsules must be used within 5 minutes. Get rid of any unused medication after the expiration date.

Inhaler: Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). The inhaler may be used for up to 7 days or for 56 capsules, whichever comes first. After 7 days of use or 56 capsules, throw away the inhaler and replace with a new inhaler.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.