Suzetrigine Tablets

What is this medication?

SUZETRIGINE (soo ZE tri jeen) treats short-term moderate to severe pain. It works by blocking your nerves from sending pain signals to your brain.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): JOURNAVX

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Liver disease
• Kidney disease
• An unusual or allergic reaction to suzetrigine, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Do not cut, crush, or chew this medication. Swallow the tablets whole. Take the first dose on an empty stomach, at least 1 hour before or 2 hours after food. After the first dose, you can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Do not take this medication with foods or drinks containing grapefruit.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Talk to your care team about what to do if you miss a dose.

What may interact with this medication?

Do not take this medication with any of the following:

• Certain medications for cancer, such as adagrasib, ceritinib, idelalisib, tucatinib, ribociclib
• Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole
• Certain medication for HIV or hepatitis, such as atazanavir, cobicistat, darunavir, delavirdine, indinavir, nelfinavir, saquinavir, tipranavir, ritonavir
• Chloramphenicol
• Clarithromycin
• Lonafarnib
• Mifepristone
• Nefazodone

This medication may also interact with the following:

• Certain progestin hormones
• St. John's wort

This medication may affect how other medications work, and other medications may affect the way this medication works. Talk with your care team about all the medications you take. They may suggest changes to your treatment plan to lower the risk of side effects and to make sure your medications work as intended.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

Some progestin hormones may not work as well while you are taking this medication. If you are taking these hormones to prevent pregnancy, you may need to use a different or backup method of contraception. Your care team can help you find the option that works for you. Talk to your care team about how long you should use different or backup methods.

This medication may cause infertility. It is usually temporary. Talk to your care team if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Itching
• Muscle spasms
• Skin rash

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix it with cat litter, dirt, coffee grounds, or another unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.