Bumetanide Nasal Spray

What is this medication?

BUMETANIDE (byoo MET a nide) reduces swelling related to heart, kidney, or liver disease. It works by helping your kidneys remove more fluid and salt from your blood through the urine. It belongs to a group of medications called diuretics.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Enbumyst

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Dehydration
• Diarrhea
• Diabetes
• Have had a nasal or nose injury or surgery
• Kidney problems
• Liver disease
• Low levels of electrolytes, such as magnesium, potassium, or sodium, in the blood
• Nasal polyps
• Runny or stuffy nose
• Vomiting
• An unusual or allergic reaction to bumetanide, sulfa medications, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

How should I use this medication?

This medication is for use in the nose. Take it as directed on the prescription label. Do not use it more often than directed. Make sure that you are using your nasal spray correctly. Ask your care team if you have any questions.

This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medication. Read the information carefully. Talk to your pharmacist or care team if you have questions.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use.

What may interact with this medication?

Do not take this medication with any of the following:

• Cidofovir
• Desmopressin
• Tranylcypromine

This medication may also interact with the following:

• Lithium
• Medications for blood pressure
• NSAIDs, medications for pain and inflammation, such as ibuprofen, indomethacin, naproxen
• Other diuretics
• Other nasal sprays
• Probenecid
• Some antibiotics, such as gentamicin
• Supplements, such as coenzyme Q10, fish oil, ginseng

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. If you take this medication for blood pressure, check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

You may need to be on a special diet while you are taking this medication. Ask your care team. Also, find out how many glasses of fluids you need to drink each day.

Talk to your care team right away if you have fever, infection, vomiting, diarrhea, or if you sweat a lot while taking this medication. The loss of too much body fluid may make it dangerous for you to take this medication.

If you take this medication for blood pressure, do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure.

Talk to your care team before breastfeeding.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
• Hearing loss, ringing in ears
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
• Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Dizziness
• Headache
• Muscle pain or cramps
• Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, ask your pharmacist or care team how to get rid of it safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.