Ibritumomab Tiuxetan injection

What is this medication?

IBRITUMOMAB TIUXETAN (EYE bri TOOM oh mab) is a monoclonal antibody that allows radiation to target specific kinds of white blood cells. It is used to treat non-Hodgkin lymphoma (NHL).

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Zevalin for In-111, Zevalin for Y-90

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

•blood disorders

•heart disease

•infection (especially a virus infection such as chickenpox, cold sores, or herpes)

•irregular heartbeat

•kidney disease

•low blood counts

•lung or breathing disease, like asthma

•an unusual or allergic reaction to ibritumomab, rituximab, albumin, mouse proteins, medicines used during bone scans, other medicines, foods, dyes, or preservatives

•pregnant or trying to get pregnant

•breast-feeding

How should I use this medication?

This medicine is for infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss a dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medication?

•medicines for growth factor treatment

•medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin

•vaccines

Talk to your doctor or health care professional before taking any of these over-the-counter medicines:

•acetaminophen

•aspirin

•ibuprofen

•ketoprofen

•naproxen

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Report any side effects that you notice during your treatment right away, such as changes in your breathing, fever, chills, dizziness or lightheadedness. These effects are more common with the first dose.

Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood work. Report any other side effects. The side effects can continue after you finish your treatment. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Do not become pregnant while taking this medicine or for up to 12 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for up to 12 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.Do not breast-feed an infant while taking this medicine.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

•low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.

•signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine

•signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine

•signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness

•breathing problems

•chest pain

•fast, irregular heartbeat

•feeling faint or lightheaded, falls

•mouth sores

•redness, blistering, peeling or loosening of the skin, including inside the mouth

•swelling of the ankles, feet, or hands

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

•anxiety

•diarrhea

•flushing

•headache

•loss of appetite

•muscle aches

•nausea, vomiting

•night sweats

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.