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Ibritumomab Tiuxetan Injection

What is this medication?

IBRITUMOMAB TIUXETAN (EYE bri TOOM oh mab) treats lymphoma. It works by releasing energy (radiation) to slow or stop the spread of cancer cells.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Zevalin for In-111, Zevalin for Y-90

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Blood disorders
  • Heart disease
  • Infection, especially a viral infection, such as chickenpox, cold sores, herpes
  • Irregular heartbeat or rhythm
  • Kidney disease
  • Low blood cell levels (white cells, red cells, and platelets)
  • Lung or breathing disease, like asthma
  • An unusual or allergic reaction to ibritumomab, albumin, mouse proteins, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

This medication is for infusion into a vein. It is administered in a hospital or clinic by a specially trained care team.

Talk to your care team regarding the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss a dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

  • Medications for growth factor treatment
  • Medications that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • Vaccines

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Talk to your care team before taking any of these over-the-counter medications:

  • Acetaminophen
  • Aspirin
  • Ibuprofen
  • Ketoprofen
  • Naproxen

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Report any side effects that you notice during your treatment right away, such as changes in your breathing, fever, chills, dizziness or lightheadedness. These effects are more common with the first dose.

Visit your care team for checks on your progress. You will need to have regular blood work. Report any other side effects. The side effects can continue after you finish your treatment. Continue your course of treatment even though you feel ill unless your care team tells you to stop.

Call your care team for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This medication decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.

Talk to your care team if you or your partner may be pregnant. Serious birth defects can occur if you take this medication during pregnancy and for 12 months after the last dose.

Do not breastfeed while taking this medication.

Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancers if you take this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
  • Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
  • Painful swelling, warmth, or redness of the skin, blisters or sores at the infusion site
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Unusual bruising or bleeding

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Cough
  • Diarrhea
  • Fatigue
  • Nausea
  • Runny or stuffy nose
  • Sore throat
  • Stomach pain

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This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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