Tezepelumab Injection

What is this medication?

TEZEPELUMAB (TEZ e PEL ue mab) prevents symptoms of severe asthma. It works by decreasing inflammation in the airways, making it easier to breathe. Do not use this medication to treat a sudden asthma attack.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Tezspire

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• parasitic (helminth) infection
• an unusual or allergic reaction to tezepelumab, hamster proteins, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is injected under the skin. It is given by a health care provider in a hospital or clinic setting.

Talk to your health care provider about the use of this medicine in children. While it may be prescribed for children as young as 12 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell them if your symptoms do not start to get better or if they get worse.

Talk to your care team about how to treat an acute asthma attack or bronchospasm (wheezing). Be sure to always have a short-acting inhaler with you. If you use your short-acting inhaler and your symptoms do not get better or if they get worse, call your care team right away.

You and your care team should develop an Asthma Action Plan that is just for you. Be sure to know what to do if you are in the yellow (asthma is getting worse) or red (medical alert) zones.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Eye irritation, itching
• Trouble breathing

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Back pain
• Joint pain
• Sore throat

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.