Plasminogen, Human Injection

What is this medication?

PLASMINOGEN, HUMAN (plaz MIN uh jen, HYOO muhn) helps reduce or heal lesions in patients with plasminogen deficiency type 1.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): RYPLAZIM

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• bleeding disorder
• lung disease
• take medicines that treat or prevent blood clots
• an unusual or allergic reaction to plasminogen, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is injected into a vein. It is usually given by a health care provider in a hospital or clinic setting. It may also be given at home. If you get this medicine at home, you will be taught how to prepare and give it. Use exactly as directed. Take it as directed on the prescription label at the same time each day it is given. Keep taking it unless your health care provider tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or health care provider to get one.

Talk to your health care provider about the use of this medicine in children. While it may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you get this medicine at the hospital or clinic: It is important not to miss your dose. Call your health care provider if you are unable to keep an appointment.

If you give yourself this medicine at home: If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Call your health care provider with questions.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your health care provider for regular checks on your progress. Tell your health care provider if your symptoms do not start to get better or if they get worse.

You may need blood work while you are taking this medicine.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions (skin rash, itching or hives; swelling of the face, lips, or tongue)
• bleeding (bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose)
• infection (fever, chills, cough, sore throat, pain or trouble passing urine)
• trouble breathing

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• bloating
• nausea
• stomach pain
• unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store the medicine between 2 and 25 degrees C (36 and 77 degrees F). Do not freeze. Keep this medicine in the original packaging until you are ready to take it. Store the diluent and syringe disc filters at room temperature between 20 and 25 degrees C (68 and 77 degrees F).

Get rid of any unused medicine or diluent after it expires or after opening, whichever is first.

To get rid of medicines that are no longer needed or have expired:

• Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medicine, ask your pharmacist or health care provider how to get rid of this medicine safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.