Dostarlimab Injection

What is this medication?

DOSTARLIMAB (dos tar li mab) is a monoclonal antibody. It treats endometrial cancer and other types of cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Jemperli

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• have had or planning to have an allogeneic stem cell transplant (uses someone else's stem cells)
• immune system problems
• lung or breathing disease
• an unusual or allergic reaction to dostarlimab, other drugs, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is infused into a vein. It is given by a health care provider in a hospital or clinic setting.

A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.

Talk to your health care provider about the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your health care provider if you are unable to keep an appointment.

What may interact with this medication?

Interactions have not been studied.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine.

You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medicine or for 4 months after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 4 months after the last dose.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions (skin rash; itching or hives; swelling of the face, lips, or tongue)
• black, tarry stools
• blurred vision OR changes in vision
• chest pain
• confusion
• cough
• diarrhea
• excessive sweating
• eye pain
• fast, irregular heartbeat
• hair loss
• hallucinations
• headache
• infusion reactions (dizziness, feeling faint or lightheaded, flushing, trouble breathing with loud or whistling sounds)
• kidney injury (trouble passing urine or change in the amount of urine)
• liver injury (dark yellow or brown urine; general ill feeling or flu-like symptoms; loss of appetite; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin)
• loss of balance or coordination
• lump or swollen lymph nodes on the neck, groin, or underarm area
• muscle weakness
• redness, blistering, peeling, or loosening of the skin, including inside the mouth
• seizures
• stomach pain
• sudden weight gain
• swelling of the arms or legs
• unusual bruising or bleeding
• weight loss

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• constipation
• muscle pain
• vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medicine is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.