What is this medicine?
PEMIGATINIB (PEM i GA ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat bile duct cancer.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Pemazyre
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
- eye disease, vision problems
- high or low levels of phosphate in the blood
- an unusual or allergic reaction to pemigatinib, other medicines, foods, dyes or preservatives
- pregnant or trying to get pregnant
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. Swallow the tablets whole. You can take it with or without food. If it upsets your stomach, take it with food. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician about the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
It is important not to miss any doses. Talk to your health care professional about what to do if you miss a dose.
What may interact with this medicine?
- certain antibiotics like erythromycin or clarithromycin
- certain antivirals for HIV or hepatitis
- certain medicines for fungal infections like ketoconazole, itraconazole, or posaconazole
- certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
- grapefruit juice
- St. Johns Wort
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your health care professional for regular checks on your progress. Tell your health care professional if your symptoms do not start to get better or if they get worse.
You may need blood work done while you are taking this medicine.
Do not become pregnant while taking this medicine or for 1 week after stopping it. Women should inform their health care professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 1 week after stopping it. There is potential for serious side effects to an unborn child. Talk to your health care professional for more information.
Do not breast-feed a child while taking this medicine or for 1 week after stopping it.
Your vision may be tested before and during use of this medicine.
Tell your health care professional right away if you have any change in your eyesight.
This medicine may cause dry eyes. If you wear contact lenses, you may feel some discomfort. Lubricating eye drops may help. See your health care professional if the problem does not go away or is severe.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
- blurred vision
- changes in vision
- eye pain
- muscle cramps
Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):
- back pain
- dry skin
- hair loss
- loss of appetite
- mouth sores
- nausea, vomiting
- stomach pain
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F).
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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