Revefenacin Nebulizer Solution

What is this medication?

REVEFENACIN (rev eh FEN uh sin) treats chronic obstructive pulmonary disease (COPD). It works by opening the airways of the lungs, making it easier to breathe. It is often called a controller medication. Do not use it to treat a sudden COPD flare-up.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): YUPELRI

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Bladder problems or difficulty passing urine
• Glaucoma
• Heart disease or irregular heartbeat
• Liver disease
• Prostate trouble
• An unusual or allergic reaction to revefenacin, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is for inhalation using a nebulizer. Nebulizers make a liquid into an aerosol that you breathe in through your mouth or your mouth and nose and into your lungs. Do not mix this medication with other medications in the nebulizer. Take it as directed on the prescription label. Do not use it more often than directed

This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medication. Read the information carefully. Talk to your pharmacist or care team if you have questions.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

This medication may interact with the following:

• Aclidinium
• Antihistamines for allergy, cough and cold
• Atropine
• Certain medications for bladder problems like oxybutynin, tolterodine
• Certain medications for Parkinson disease like benztropine, trihexyphenidyl
• Certain medications for stomach problems like dicyclomine, hyoscyamine
• Certain medications for travel sickness like scopolamine
• Cyclosporine
• Glycopyrrolate
• Ipratropium
• Rifampin
• Tiotropium
• Umeclidinium

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not improve. Do not use more medication than directed. If your symptoms get worse while you are using this medication, call your care team right away.

Do not get this medication in your eyes. It can cause irritation, pain, or blurred vision.

Clean the nebulizer as directed in the patient information sheet that comes with this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
• Trouble passing urine
• Wheezing or trouble breathing that is worse after use

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Back pain
• Cough
• Headache
• Runny or stuffy nose
• Sore throat

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep unopened vials in the foil pouch. Get rid of any unused medication after the expiration date.

To get rid of medication that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.