Cenegermin Eye Solution

What is this medication?

CENEGERMIN (SEN jur min) treats neurotrophic keratitis, a condition that causes damage to the clear outer layer of the eye (cornea). It works by healing and repairing the nerves in the eye.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): OXERVATE

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Infection in the eye
• Wear contact lenses
• An unusual or allergic reaction to cenegermin, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is only for use in the eye. Follow the directions on the prescription label. Wash hands before and after use. Tilt your head back slightly and pull your lower eyelid down with your index finger to form a pouch. Try not to touch the tip of the dropper to your eye, fingertips, or any other surface. Squeeze the drop into the pouch. Blink for a few moments to spread the drops. Use exactly as directed. Use your doses at regular intervals. Do not use your medication more often than directed.

Talk to your care team about use of this medication in children. While this medication may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use the next dose at your regular time. Do not use double or extra doses.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular eye exams. Ask your care team if you should continue to use this medication if you injure your eyes or need eye surgery. If you develop an eye infection, contact your care team immediately.

If you wear contact lenses, you should not put this medication in your eyes while wearing the lenses. After using the eye drops, wait about 15 minutes before putting lenses in your eyes.

You can use other eye medications while using this medication; however you should wait at least 15 minutes after using this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Eye pain

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Eye irritation or itching
• Increased tears after use

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

You will be instructed how to store this medication.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.