What is this medication?

ZANUBRUTINIB (zan ue broo ti nib) targets proteins in cancer cells and stops the cancer cells from growing. It treats mantle cell lymphoma, marginal zone lymphoma, and Waldenstrom macroglobulinemia.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): BRUKINSA

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • bleeding disorders
  • having surgery
  • high blood pressure
  • history of irregular heartbeat
  • infection including hepatitis B virus infection
  • liver disease
  • take medicines that treat or prevent blood clots
  • an unusual or allergic reaction to zanubrutinib, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Do not cut, crush or chew this medicine. Do not take with grapefruit juice. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. Take the next dose at your regular time. Do not take double or extra doses.

What may interact with this medication?

This medicine may interact with the following medications:

  • antiviral medications for HIV or AIDS
  • aprepitant
  • calcium channel blockers like diltiazem and verapamil
  • certain antibiotics like clarithromycin, erythromycin, and nafcillin
  • certain medicines for fungal infections like fluconazole, ketoconazole, itraconazole, posaconazole, and voriconazole
  • certain medicines for seizures like carbamazepine and phenytoin
  • ciprofloxacin
  • conivaptan
  • crizotinib
  • cyclosporine
  • dronedarone
  • enzalutamide
  • fluvoxamine
  • grapefruit juice
  • idelalisib
  • imatinib
  • mitotane
  • nefazodone
  • rifampin
  • St. John's wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your health care provider for regular checks on your progress. It may be some time before you see the benefit from this medicine.

You may need blood work done while you are taking this medicine.

This medicine may increase your risk to bruise or bleed. Call your health care provider if you notice any unusual bleeding.

This medicine may increase your risk of getting an infection. Call your health care provider for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

If you are going to need surgery or any other procedures, tell your health care provider that you are using this medicine. Tell your dentist and dental surgeon that you are taking this medicine. You should not have major dental surgery while on this medicine. See your dentist to have a dental exam and fix any dental problems before starting this medicine.

Talk to your health care provider about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen.

Do not become pregnant while taking this medicine or for 1 week after stopping it. Women should inform their health care provider if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 1 week after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care provider for more information. Do not breast-feed an infant while taking this medicine or for 2 weeks after stopping it.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions (skin rash; itching or hives; swelling of the face, lips, or tongue)
  • bleeding (bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose)
  • chest pain
  • confusion
  • dizziness
  • fast, irregular heartbeat
  • increase in blood pressure
  • infection (fever, chills, cough, sore throat, pain or difficulty passing urine)
  • low red blood cell counts (trouble breathing; feeling faint; lightheaded, falls; unusually weak or tired)
  • severe headaches
  • trouble speaking or understanding

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • bone pain
  • cough
  • diarrhea
  • muscle pain
  • nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medicine after the expiration date.

To get rid of medicines that are no longer needed or have expired:

  • Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, empty the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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