Iobenguane I 131 injection

What is this medication?

IOBENGUANE I-131 (eye oh BEN gwane) is a radiopharmaceutical agent used to treat certain types of neuroendocrine tumors.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): AZEDRA

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• high blood pressure
• kidney disease
• thyroid disease
• an unusual or allergic reaction to iobenguane I-131, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 12 years old for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses as directed. It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medication?

This medicine may interact with the following medications:

• certain medicines for blood pressure, heart disease, irregular heart beat like labetalol
• certain medicines for depression, anxiety, or psychotic disturbances like amitriptyline, bupropion, duloxetine, mirtazapine, or venlafaxine
• dextroamphetamine
• ephedra
• ephedrine
• ma huang
• MAOIs like Carbex, Eldepryl, Marplan, Nardil, Parnate, and Linezolid
• naphazoline
• phenylephrine
• phenylpropanolamine
• pseudoephedrine
• reserpine
• stimulant medicines for attention disorders, weight loss, or to stay awake like methylphenidate, dextroamphetamine, or phenteramine
• St John's Wort
• tramadol
• yohimbine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine. You may need blood work done while you are taking this medicine.

Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.

Drink fluids as directed.

Do not become pregnant while taking this medicine and for 7 months after the last dose. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine and for 4 months after the last dose. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine and for 80 days after the last dose.

This medicine may interfere with the ability to have a child. Talk with your doctor or health care professional if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• cough
• low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
• signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
• signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness
• signs of infection - fever or chills, cough, sore throat, pain passing urine
• signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• dizziness
• dry mouth
• nausea, vomiting
• stomach pain
• tiredness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is only given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.