Tildrakizumab Injection

What is this medication?

TILDRAKIZUMAB (til drak iz u mab) is a monoclonal antibody. It is used to treat psoriasis.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): ILUMYA

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• immune system problems
• infection
• recently received or are scheduled to receive a vaccine
• tuberculosis, a positive skin test for tuberculosis, or have recently been in close contact with someone who has tuberculosis
• an unusual or allergic reaction to tildrakizumab, other medicines, foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is for injection under the skin. It is given by a health care professional in a hospital or clinic setting.

A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Call your doctor of health care professional if you are unable to keep an appointment. If you miss a dose, take it as soon as you can. Then be sure to take your next dose on your regular schedule. Do not take double or extra doses. If you have questions about a missed injection, call your health care professional.

What may interact with this medication?

Do not take this medicine with any of the following medications:

• live virus vaccines

This medicine may also interact with the following medications:

• inactivated vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse.

You will be tested for tuberculosis (TB) before you start this medicine. If your doctor prescribes any medicine for TB, you should start taking the TB medicine before starting this medicine. Make sure to finish the full course of TB medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine can decrease the response to a vaccine. If you need to get vaccinated, tell your health care professional if you have received this medicine. Extra booster doses may be needed. Talk to your doctor to see if a different vaccination schedule is needed.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash; itching or hives; swelling of the face, lips, or tongue
• fever or chills; cough; sore throat; pain or trouble passing urine

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• pain, redness, or irritation at site where injected

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.