What is this medicine?
Siponimod (si PON i mod) may help prevent relapses of multiple sclerosis. This medicine is not a cure.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): MAYZENT
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
- heart disease
- high blood pressure
- history of irregular heartbeat
- history of stroke
- immune system problems
- infection (especially a viral infection such as chickenpox, cold sores, or herpes)
- liver disease
- low blood counts, like white cells, platelets, or red blood cells
- lung or breathing disease, like asthma
- recently received or scheduled to receive a vaccine
- an unusual or allergic reaction to siponimod, other medicines, foods, dyes, or preservatives
- pregnant or trying to get pregnant
How should I use this medicine?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
Talk to your pediatrician about the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
It is important not to miss any doses. Talk to your healthcare professional about what to do if you miss a dose.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
- certain antivirals for HIV or hepatitis
- certain medicines for blood pressure, heart disease, irregular heart beat
- certain medicines for fungal infections like ketoconazole, itraconazole, or posaconazole
- certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
- live virus vaccines
- medicines that lower your chance of fighting infection
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your healthcare professional for regular checks on your progress. Tell your healthcare professional if your symptoms do not start to get better or if they get worse.
In some patients, this medicine may cause a serious brain infection that may cause death. If you have any problems seeing, thinking, speaking, walking, or standing, tell your healthcare professional right away. If you cannot reach your healthcare professional, urgently seek other source of medical care.
Tell your doctor or health care professional right away if you have any change in your eyesight.
Your vision may be tested before and during use of this medicine.
You may need blood work done while you are taking this medicine.
Call your healthcare professional for advice if you get a fever, chills, or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This medicine decreases your body's ability to fight infections. Try to avoid being around people who are sick.
Talk with your doctor if you have not had chickenpox or the vaccine for chickenpox.
This medicine can decrease the response to a vaccine. If you need to get vaccinated, tell your healthcare professional if you have received this medicine within the last 4 weeks. Extra booster doses may be needed. Talk to your healthcare professional to see if a different vaccination schedule is needed.
Talk to your healthcare professional about your risk of cancer. You may be more at risk for certain types of cancer if you take this medicine.
Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. If you are a female who can become pregnant, you should use effective birth control during your treatment with this medicine and for at least 10 days after you stop taking it. Talk to your health care professional for more information.
If you stop taking this medicine, your MS symptoms may get worse. You may have more weakness, trouble using your arms or legs, or changes in balance. Talk to your healthcare provider right away if your symptoms get worse.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- changes in vision
- headache with fever, neck stiffness, sensitivity to light, nausea, or confusion
- signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded; falls; breathing problems
- signs and symptoms of a stroke like changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking; dizziness; loss of balance or coordination
- signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine
- signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
- unusually slow heartbeat
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
- pain in legs or arms
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
You will be instructed on how to store this medicine. Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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