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Ubrogepant Tablets

What is this medication?

UBROGEPANT (ue BROE je pant) treats migraines. It works by blocking a substance in the body that causes migraines. It is not used to prevent migraines.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Ubrelvy

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Circulation problems in fingers or toes (Raynaud syndrome)
  • High blood pressure
  • Kidney disease
  • Liver disease
  • An unusual or allergic reaction to ubrogepant, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use.

What may interact with this medication?

Do not take this medication with any of the following:

  • Adagrasib
  • Ceritinib
  • Certain antibiotics, such as chloramphenicol, clarithromycin, telithromycin
  • Certain antivirals for HIV, such as atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, ritonavir
  • Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole
  • Conivaptan
  • Grapefruit
  • Idelalisib
  • Mifepristone
  • Nefazodone
  • Ribociclib

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This medication may also interact with the following:

  • Carvedilol
  • Certain medications for seizures, such as phenobarbital, phenytoin
  • Ciprofloxacin
  • Cyclosporine
  • Eltrombopag
  • Fluconazole
  • Fluvoxamine
  • Quinidine
  • Rifampin
  • St. John's wort
  • Verapamil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Increase in blood pressure
  • Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Drowsiness
  • Dry mouth
  • Fatigue
  • Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 15 and 30 degrees C (59 and 86 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, pour the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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