Entrectinib works to stop cancer cells from growing to treat lung cancer. Lung cancer happens when harmful cells in your lungs grow uncontrollably. This medication comes in a capsule form that you can take by mouth with a glass of water as directed. Don’t take this medication with grapefruit juice.
ENTRECTINIB (en TREK ti nib) treats some types of cancer. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): ROZLYTREK
They need to know if you have any of these conditions:
Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medication. Swallow the capsules whole. Do not take with grapefruit juice. You can take it with or without food. If it upsets your stomach, take it with food. Take your medication at regular intervals. Do not take it more often than directed. Do not stop taking except on your care team's advice.
Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 12 years for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
Do not take this medication with any of the following:
This medication may also interact with the following medications:
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
This medication may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop. You will need blood work done while you are taking this medication.
Tell your care team right away if you have any change in your eyesight.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your care team. These medications may hide a fever.
Call your care team for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This medication decreases your body's ability to fight infections. Try to avoid being around people who are sick.
Do not become pregnant while taking this medication or for 5 weeks after stopping it. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medication and for 3 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your care team or pharmacist for more information.
Do not breast-feed while taking this medication or for 7 days after stopping it.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children and pets.
Store below 30 degrees C (86 degrees F). Keep this medication in the original container. Protect from moisture. Keep the container tightly closed. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.