What is this medicine?

RISANKIZUMAB (RIS an KIZ ue mab) is used to treat plaque psoriasis.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Skyrizi

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • immune system problems
  • infection
  • recently received or are scheduled to receive a vaccine
  • tuberculosis, a positive skin test for tuberculosis, or have recently been in close contact with someone who has tuberculosis
  • an unusual or allergic reaction to risankizumab, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection under the skin. It is usually given by a health care professional in a hospital or clinic setting. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. Then, continue dosing at the regularly scheduled time.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • live virus vaccines

This medicine may also interact with the following medications:

  • inactivated vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse.

You will be tested for tuberculosis (TB) before you start this medicine. If your doctor prescribes any medicine for TB, you should start taking the TB medicine before starting this medicine. Make sure to finish the full course of TB medicine.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine can decrease the response to a vaccine. If you need to get vaccinated, tell your health care professional if you have received this medicine. Extra booster doses may be needed. Talk to your doctor to see if a different vaccination schedule is needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash; itching or hives; swelling of the face, lips, or tongue
  • sign and symptoms of an infection like fever or chills; cough; sore throat; pain or trouble passing urine
  • swollen lymph nodes in the neck, underarm, or groin areas
  • unusually weak or tired
  • breathing problems
  • unexplained weight loss

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • headache
  • pain, redness, or irritation at site where injected
  • tiredness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F) in the original carton. Do not freeze. Keep in the original carton to protect from light. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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