Alprostadil intracavernosal injection

What is this medication?

ALPROSTADIL (al PROS ta dil) is used to treat erectile dysfunction (ED). This medicine helps to create and maintain an erection.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Caverject, Caverject Impulse, Edex


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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • An abnormally formed penis
  • Have been advised not to engage in sexual activity
  • Have ever had a painful erection that lasted more than 4 hours
  • Heart problems
  • Leukemia
  • Low blood pressure
  • Penile implant
  • Sickle cell disease or trait
  • Tumor of the bone marrow (multiple myeloma)
  • An unusual or allergic reaction to alprostadil or other medications, foods, dyes, or preservatives

How should I use this medication?

This medication is injected into the penis. You will be taught how to prepare and give it. Use exactly as directed. Do not take your medication more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

This medication is for use in men only and is not for use in children.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.


What if I miss a dose?

You should not use this medication more than 3 times a week. Each dose should be given at least 24 hours apart.

What may interact with this medication?

  • Medications for blood pressure

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


What should I watch for while using this medication?

Contact your care team right away if you have an erection that lasts longer than 4 hours or if it becomes painful. This may be a sign of a serious problem and must be treated right away to prevent permanent damage.

Do not change the dose of your medication. Call your care team to determine if your dose needs to be changed.

Using this medication does not protect you or your partner against HIV infection or other sexually transmitted infections (STIs).

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • prolonged or painful erection

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • bleeding, bruising, or pain at site of injection
  • change in blood pressure

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of reach of children and pets.

Caverject: Store unopened product at or below 25 degrees C (77 degrees F). Do not freeze. See product instructions for storage when product is in use. Different products may have different instructions for storage. Get rid of any unused medication after the expiration date.

Edex: Store unopened product between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. See product instructions for storage when product is in use. Get rid of any unused medication after the expiration date.

When traveling, do not store this medication in checked luggage during air travel or leave in a closed automobile.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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